| UniProt ID | SH2D5_HUMAN | |
|---|---|---|
| UniProt AC | Q6ZV89 | |
| Protein Name | SH2 domain-containing protein 5 {ECO:0000312|HGNC:HGNC:28819} | |
| Gene Name | SH2D5 {ECO:0000312|HGNC:HGNC:28819} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 423 | |
| Subcellular Localization | Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . | |
| Protein Description | May be involved in synaptic plasticity regulation through the control of Rac-GTP levels.. | |
| Protein Sequence | MQKAGAGGRRASDCGLAPHRPRCITKFAQYVGSFPVDDLDTQESVWLVQQQLWALKDCPRRRAVILKFSLQGLKIYSGEGEVLLMAHALRRILYSTWCPADCQFAFMARNPRSPASKLFCHLFVGSQPGEVQILHLLLCRSFQLAYLLQHPEERAQPEPCPGPTGEVPLKPLSSSGGLVREPFGRDQLSQNVHALVSFRRLPAEGLVGSGKELPESEGRARHARLGNPYCSPTLVRKKAIRSKVIRSGAYRGCTYETQLQLSAREAFPAAWEAWPRGPGGHSCLVESEGSLTENIWAFAGISRPCALALLRRDVLGAFLLWPELGASGQWCLSVRTQCGVVPHQVFRNHLGRYCLEHLPAEFPSLEALVENHAVTERSLFCPLDMGRLNPTYEEQDCGPPGRPPRTLRPLSHAKSEAELQGLG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 12 | Phosphorylation | GAGGRRASDCGLAPH CCCCCCHHHCCCCCC | 31.46 | 25394399 | |
| 86 | Ubiquitination | EGEVLLMAHALRRIL CHHHHHHHHHHHHHH | 5.69 | 30230243 | |
| 164 | Phosphorylation | PEPCPGPTGEVPLKP CCCCCCCCCCCCCCC | 52.46 | - | |
| 170 | Ubiquitination | PTGEVPLKPLSSSGG CCCCCCCCCCCCCCC | 37.53 | 30230243 | |
| 178 | Phosphorylation | PLSSSGGLVREPFGR CCCCCCCCCCCCCCH | 3.61 | 32142685 | |
| 197 | Phosphorylation | QNVHALVSFRRLPAE HHHHHHHHCCCCCCC | 17.56 | 30266825 | |
| 209 | Phosphorylation | PAEGLVGSGKELPES CCCCCCCCCCCCCCC | 38.93 | 30576142 | |
| 229 | Phosphorylation | HARLGNPYCSPTLVR HHHCCCCCCCHHHHH | 15.01 | 25394399 | |
| 231 | Phosphorylation | RLGNPYCSPTLVRKK HCCCCCCCHHHHHHH | 18.31 | 19664994 | |
| 233 | Phosphorylation | GNPYCSPTLVRKKAI CCCCCCHHHHHHHHH | 22.91 | 23927012 | |
| 255 | Phosphorylation | GAYRGCTYETQLQLS CCCCCCCHHHHHHHH | 22.51 | 16464493 | |
| 262 | Phosphorylation | YETQLQLSAREAFPA HHHHHHHHHHHHCCC | 16.60 | 32142685 | |
| 406 | Phosphorylation | PPGRPPRTLRPLSHA CCCCCCCCCCCCCCC | 32.66 | 28176443 | |
| 411 | Phosphorylation | PRTLRPLSHAKSEAE CCCCCCCCCCCCHHH | 24.87 | 25394399 | |
| 415 | Phosphorylation | RPLSHAKSEAELQGL CCCCCCCCHHHHCCC | 42.70 | 27422710 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SH2D5_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SH2D5_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SH2D5_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of SH2D5_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231, AND MASSSPECTROMETRY. | |
