SVIP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SVIP_HUMAN
• UniProt AC: Q8NHG7
• Protein Name: Small VCP/p97-interacting protein
• Gene Name: SVIP
• Organism: Homo sapiens (Human).
• Sequence Length: 77
• Subcellular Localization: Smooth endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane ; Lipid-anchor .
• Protein Sequence: MGLCFPCPGESAPPTPDLEEKRAKLAEAAERRQKEAASRGILDVQSVQEKRKKKEKIEKQIATSGPPPEGGLRWTVS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGLCFPCPG ------CCCCCCCCC	31.02	25255805
11	Phosphorylation	CFPCPGESAPPTPDL CCCCCCCCCCCCCCH	52.57	26657352
15	Phosphorylation	PGESAPPTPDLEEKR CCCCCCCCCCHHHHH	28.51	26657352
24	Ubiquitination	DLEEKRAKLAEAAER CHHHHHHHHHHHHHH	52.87	33845483
34	Ubiquitination	EAAERRQKEAASRGI HHHHHHHHHHHHCCC	47.73	29967540
36	Ubiquitination	AERRQKEAASRGILD HHHHHHHHHHCCCCC	20.13	29967540
46	Phosphorylation	RGILDVQSVQEKRKK CCCCCHHHHHHHHHH	26.14	29255136
50	Ubiquitination	DVQSVQEKRKKKEKI CHHHHHHHHHHHHHH	53.04	33845483
52	Ubiquitination	QSVQEKRKKKEKIEK HHHHHHHHHHHHHHH	78.31	33845483
54	Ubiquitination	VQEKRKKKEKIEKQI HHHHHHHHHHHHHHH	68.24	24816145
56	Ubiquitination	EKRKKKEKIEKQIAT HHHHHHHHHHHHHHH	66.11	24816145
59	Ubiquitination	KKKEKIEKQIATSGP HHHHHHHHHHHHCCC	50.94	33845483
61	Ubiquitination	KEKIEKQIATSGPPP HHHHHHHHHHCCCCC	7.18	33845483
63	Phosphorylation	KIEKQIATSGPPPEG HHHHHHHHCCCCCCC	35.53	25850435
64	O-linked_Glycosylation	IEKQIATSGPPPEGG HHHHHHHCCCCCCCC	40.04	28657654
64	Phosphorylation	IEKQIATSGPPPEGG HHHHHHHCCCCCCCC	40.04	25850435
75	Phosphorylation	PEGGLRWTVS----- CCCCCCCCCC-----	12.39	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SVIP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SVIP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SVIP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DERL1_HUMAN	DERL1	physical	17872946
TERA_HUMAN	VCP	physical	17872946
SYVN1_HUMAN	SYVN1	physical	17872946
AMFR_HUMAN	AMFR	physical	17872946
TFR1_HUMAN	TFRC	physical	17872946
UFD1_HUMAN	UFD1L	physical	17872946
CALX_HUMAN	CANX	physical	17872946
GOGA1_HUMAN	GOLGA1	physical	17872946
NPL4_HUMAN	NPLOC4	physical	17872946
SELS_HUMAN	VIMP	physical	17872946
TERA_HUMAN	VCP	physical	21909394
LAMP1_HUMAN	LAMP1	physical	21909394
TERA_HUMAN	VCP	physical	24100225

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.