HERP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HERP1_HUMAN
• UniProt AC: Q15011
• Protein Name: Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
• Gene Name: HERPUD1
• Organism: Homo sapiens (Human).
• Sequence Length: 391
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein .
• Protein Description: Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated amyloid-beta protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway. [PubMed: 18307982]
• Protein Sequence: MESETEPEPVTLLVKSPNQRHRDLELSGDRGWSVGHLKAHLSRVYPERPRPEDQRLIYSGKLLLDHQCLRDLLPKQEKRHVLHLVCNVKSPSKMPEINAKVAESTEEPAGSNRGQYPEDSSSDGLRQREVLRNLSSPGWENISRPEAAQQAFQGLGPGFSGYTPYGWLQLSWFQQIYARQYYMQYLAATAASGAFVPPPSAQEIPVVSAPAPAPIHNQFPAENQPANQNAAPQVVVNPGANQNLRMNAQGGPIVEEDDEINRDWLDWTYSAATFSVFLSILYFYSSLSRFLMVMGATVVMYLHHVGWFPFRPRPVQNFPNDGPPPDVVNQDPNNNLQEGTDPETEDPNHLPPDRDVLDGEQTSPSFMSTAWLVFKTFFASLLPEGPPAIAN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MESETEPE -------CCCCCCCC	13.27	22814378
3	Phosphorylation	-----MESETEPEPV -----CCCCCCCCCE	48.82	23186163
11	Phosphorylation	ETEPEPVTLLVKSPN CCCCCCEEEEECCCC	25.70	23186163
33	Phosphorylation	LSGDRGWSVGHLKAH ECCCCCCCHHHHHHH	22.50	28857561
38	Ubiquitination	GWSVGHLKAHLSRVY CCCHHHHHHHHHHHC	28.25	-
59	Phosphorylation	EDQRLIYSGKLLLDH HHCCEEECCEEECCH	23.58	-
61	Ubiquitination	QRLIYSGKLLLDHQC CCEEECCEEECCHHH	29.98	21906983
61 (in isoform 3)	Ubiquitination	-	29.98	21906983
61 (in isoform 2)	Ubiquitination	-	29.98	21906983
61 (in isoform 1)	Ubiquitination	-	29.98	21906983
75	Ubiquitination	CLRDLLPKQEKRHVL HHHHHCCHHHHHHHE	71.68	-
89	Ubiquitination	LHLVCNVKSPSKMPE EEEEEECCCCCCCCC	42.53	-
89	Acetylation	LHLVCNVKSPSKMPE EEEEEECCCCCCCCC	42.53	20167786
90	Phosphorylation	HLVCNVKSPSKMPEI EEEEECCCCCCCCCH	30.07	20068231
92	Phosphorylation	VCNVKSPSKMPEINA EEECCCCCCCCCHHH	48.99	29214152
93	Ubiquitination	CNVKSPSKMPEINAK EECCCCCCCCCHHHE	62.96	-
99 (in isoform 2)	Ubiquitination	-	17.23	21906983
99 (in isoform 3)	Ubiquitination	-	17.23	21906983
100	Ubiquitination	KMPEINAKVAESTEE CCCCHHHECCCCCCC	37.17	2190698
100 (in isoform 1)	Ubiquitination	-	37.17	21906983
135	Phosphorylation	REVLRNLSSPGWENI HHHHHHHCCCCCHHC	37.73	15489334
136	Phosphorylation	EVLRNLSSPGWENIS HHHHHHCCCCCHHCC	30.51	21815630
189	Phosphorylation	YMQYLAATAASGAFV HHHHHHHHHHCCCCC	19.70	28787133
200	Phosphorylation	GAFVPPPSAQEIPVV CCCCCCCCHHCCCEE	48.64	28787133
375	Ubiquitination	STAWLVFKTFFASLL HHHHHHHHHHHHHHC	36.62	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	AMFR	Q9UKV5	PMID:17310145
-	K	Ubiquitination	E3 ubiquitin ligase	SH3RF1	Q7Z6J0	PMID:17420289

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HERP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
59	Phosphorylation	50 (9)	R ⇒ H	rs2217332	Metabolic syndrome	20694148

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LFA3_HUMAN	CD58	physical	16169070
RFA2_HUMAN	RPA2	physical	16169070
STAR9_HUMAN	STARD9	physical	16169070
UBQL1_HUMAN	UBQLN1	physical	18307982
UBQL2_HUMAN	UBQLN2	physical	18307982
UBQL4_HUMAN	UBQLN4	physical	18307982
SYVN1_HUMAN	SYVN1	physical	16289116
DERL1_HUMAN	DERL1	physical	16289116
TERA_HUMAN	VCP	physical	16289116
SELS_HUMAN	VIMP	physical	16289116
SYUA_HUMAN	SNCA	physical	20604806
SNCAP_HUMAN	SNCAIP	physical	20604806
SIAH1_HUMAN	SIAH1	physical	20604806
SYVN1_HUMAN	SYVN1	physical	21149444
XRCC6_HUMAN	XRCC6	physical	21900206
GDIR1_HUMAN	ARHGDIA	physical	21900206
PSN1_HUMAN	PSEN1	physical	14550564
UBC_HUMAN	UBC	physical	14550564
A4_HUMAN	APP	physical	21832049
CAN15_HUMAN	CAPN15	physical	26186194
SH3R1_HUMAN	SH3RF1	physical	17420289
CAN15_HUMAN	CAPN15	physical	28514442
TBK1_HUMAN	TBK1	physical	28954889

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.