LFA3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LFA3_HUMAN
• UniProt AC: P19256
• Protein Name: Lymphocyte function-associated antigen 3
• Gene Name: CD58
• Organism: Homo sapiens (Human).
• Sequence Length: 250
• Subcellular Localization: Isoform 1: Cell membrane; Single-pass type I membrane protein.
• Protein Description: Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells..
• Protein Sequence: MVAGSDAGRALGVLSVVCLLHCFGFISCFSQQIYGVVYGNVTFHVPSNVPLKEVLWKKQKDKVAELENSEFRAFSSFKNRVYLDTVSGSLTIYNLTSSDEDEYEMESPNITDTMKFFLYVLESLPSPTLTCALTNGSIEVQCMIPEHYNSHRGLIMYSWDCPMEQCKRNSTSIYFKMENDLPQKIQCTLSNPLFNTTSSIILTTCIPSSGHSRHRYALIPIPLAVITTCIVLYMNGILKCDRKPDRTNSN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	N-linked_Glycosylation	IYGVVYGNVTFHVPS CEEEEECEEEEECCC	16.39	UniProtKB CARBOHYD
62	Ubiquitination	LWKKQKDKVAELENS HHHHHHHHHHHHHCC	50.83	29967540
78	Ubiquitination	FRAFSSFKNRVYLDT HHHHHHCCCCEEEEE	45.88	-
94	N-linked_Glycosylation	SGSLTIYNLTSSDED CCEEEEEECCCCCCC	32.75	UniProtKB CARBOHYD
109	N-linked_Glycosylation	EYEMESPNITDTMKF CCEECCCCHHHHHHH	60.10	UniProtKB CARBOHYD
135	N-linked_Glycosylation	TLTCALTNGSIEVQC CEEEEEECCEEEEEE	42.96	UniProtKB CARBOHYD
169	N-linked_Glycosylation	PMEQCKRNSTSIYFK CHHHHHHCCCEEEEE	34.82	17660510
170	Phosphorylation	MEQCKRNSTSIYFKM HHHHHHCCCEEEEEE	27.80	29978859
171	Phosphorylation	EQCKRNSTSIYFKME HHHHHCCCEEEEEEC	23.77	29978859
172	Phosphorylation	QCKRNSTSIYFKMEN HHHHCCCEEEEEECC	18.34	29978859
174	Phosphorylation	KRNSTSIYFKMENDL HHCCCEEEEEECCCC	9.27	29978859
195	N-linked_Glycosylation	TLSNPLFNTTSSIIL EECCCCCCCCCEEEE	50.56	UniProtKB CARBOHYD
209	Phosphorylation	LTTCIPSSGHSRHRY EEEECCCCCCCCCCE	34.86	-
247 (in isoform 3)	Phosphorylation	-	50.83	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LFA3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LFA3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LFA3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DNJA1_HUMAN	DNAJA1	physical	16169070
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• D02800: Alefacept (USAN/INN); Amevive (TN)
• DrugBank
• There are no disease associations of PTM sites.