CALCR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CALCR_HUMAN
• UniProt AC: P30988
• Protein Name: Calcitonin receptor
• Gene Name: CALCR
• Organism: Homo sapiens (Human).
• Sequence Length: 508
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin..
• Protein Sequence: MQFSGEKISGQRDLQKSKMRFTFTSRCLALFLLLNHPTPILPAFSNQTYPTIEPKPFLYVVGRKKMMDAQYKCYDRMQQLPAYQGEGPYCNRTWDGWLCWDDTPAGVLSYQFCPDYFPDFDPSEKVTKYCDEKGVWFKHPENNRTWSNYTMCNAFTPEKLKNAYVLYYLAIVGHSLSIFTLVISLGIFVFFRKLTTIFPLNWKYRKALSLGCQRVTLHKNMFLTYILNSMIIIIHLVEVVPNGELVRRDPVSCKILHFFHQYMMACNYFWMLCEGIYLHTLIVVAVFTEKQRLRWYYLLGWGFPLVPTTIHAITRAVYFNDNCWLSVETHLLYIIHGPVMAALVVNFFFLLNIVRVLVTKMRETHEAESHMYLKAVKATMILVPLLGIQFVVFPWRPSNKMLGKIYDYVMHSLIHFQGFFVATIYCFCNNEVQTTVKRQWAQFKIQWNQRWGRRPSNRSARAAAAAAEAGDIPIYICHQEPRNEPANNQGEESAEIIPLNIIEQESSA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	QFSGEKISGQRDLQK CCCCCCCCCCHHHHH	2.33	26425664
22	Phosphorylation	QKSKMRFTFTSRCLA HHHHHHHHHHHHHHH	8.72	29083192
24	Phosphorylation	SKMRFTFTSRCLALF HHHHHHHHHHHHHHH	31.79	22210691
28	N-linked_Glycosylation	FTFTSRCLALFLLLN HHHHHHHHHHHHHHH	31.59	-
46	N-linked_Glycosylation	PILPAFSNQTYPTIE CCCCCCCCCCCCCCC	38.81	UniProtKB CARBOHYD
59	Phosphorylation	IEPKPFLYVVGRKKM CCCCCEEEEECCHHH	2.45	-
71	Phosphorylation	KKMMDAQYKCYDRMQ HHHHCCHHHHHHHHH	17.14	-
73	N-linked_Glycosylation	MMDAQYKCYDRMQQL HHCCHHHHHHHHHHC	38.28	-
74	Phosphorylation	MDAQYKCYDRMQQLP HCCHHHHHHHHHHCC	33.36	-
91	N-linked_Glycosylation	QGEGPYCNRTWDGWL CCCCCCCCCCCCCEE	17.93	UniProtKB CARBOHYD
125	N-linked_Glycosylation	PDFDPSEKVTKYCDE CCCCCHHHHHHHCCC	40.89	-
128 (in isoform 3)	Phosphorylation	-	4.95	22210691
130	N-linked_Glycosylation	SEKVTKYCDEKGVWF HHHHHHHCCCCCCEE	28.05	-
143	N-linked_Glycosylation	WFKHPENNRTWSNYT EEECCCCCCEECCEE	51.07	UniProtKB CARBOHYD
148	N-linked_Glycosylation	ENNRTWSNYTMCNAF CCCCEECCEEEECCC	1.19	UniProtKB CARBOHYD
149	Phosphorylation	NNRTWSNYTMCNAFT CCCEECCEEEECCCC	6.08	-
150	Phosphorylation	NRTWSNYTMCNAFTP CCEECCEEEECCCCH	5.86	-
156	Phosphorylation	YTMCNAFTPEKLKNA EEEECCCCHHHHHHH	18.05	-
175 (in isoform 2)	Phosphorylation	-	45.06	22210691
175 (in isoform 6)	Phosphorylation	-	45.06	22210691
196	Phosphorylation	VFFRKLTTIFPLNWK HHHHHHHCCCCCCHH	27.71	-
252	Phosphorylation	LVRRDPVSCKILHFF CCCCCCCCHHHHHHH	2.90	-
475	Phosphorylation	EAGDIPIYICHQEPR HHCCCCEEEEECCCC	27.22	27642862
493	Phosphorylation	ANNQGEESAEIIPLN CCCCCCCCCEEEECC		30278072

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CALCR_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CALCR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CALCR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LRP1_HUMAN	LRP1	physical	12821648
TSP1_HUMAN	THBS1	physical	12147682
GASP1_HUMAN	GPRASP1	physical	15086532
GASP2_HUMAN	GPRASP2	physical	15086532

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.