SPDYA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPDYA_HUMAN
• UniProt AC: Q5MJ70
• Protein Name: Speedy protein A
• Gene Name: SPDYA {ECO:0000312|HGNC:HGNC:30613}
• Organism: Homo sapiens (Human).
• Sequence Length: 313
• Subcellular Localization: Nucleus .
• Protein Description: Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2. [PubMed: 12972555 Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T-loop that obstructs the substrate-binding cleft prior to kinase activation]
• Protein Sequence: MRHNQMCCETPPTVTVYVKSGSNRSHQPKKPITLKRPICKDNWQAFEKNTHNNNKSKRPKGPCLVIQRQDMTAFFKLFDDDLIQDFLWMDCCCKIADKYLLAMTFVYFKRAKFTISEHTRINFFIALYLANTVEEDEEETKYEIFPWALGKNWRKLFPNFLKLRDQLWDRIDYRAIVSRRCCEEVMAIAPTHYIWQRERSVHHSGAVRNYNRDEVQLPRGPSATPVDCSLCGKKRRYVRLGLSSSSSLSSHTAGVTEKHSQDSYNSLSMDIIGDPSQAYTGSEVVNDHQSNKGKKTNFLKKDKSMEWFTGSEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
222	Phosphorylation	VQLPRGPSATPVDCS CCCCCCCCCCCCCHH	47.82	-
224	Phosphorylation	LPRGPSATPVDCSLC CCCCCCCCCCCHHHC	28.34	-
247	Phosphorylation	LGLSSSSSLSSHTAG ECCCCCCCCHHCCCC	33.93	-
252	Phosphorylation	SSSLSSHTAGVTEKH CCCCHHCCCCCCCCC	27.36	-
256	Phosphorylation	SSHTAGVTEKHSQDS HHCCCCCCCCCCCCC	38.10	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	SKP2	Q13309	PMID:19622356
-	K	Ubiquitination	E3 ubiquitin ligase	NEDD4	P46934	PMID:19054764

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPDYA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPDYA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDN1B_MOUSE	Cdkn1b	physical	12972555
CDN1B_HUMAN	CDKN1B	physical	12972555
CDN1B_HUMAN	CDKN1B	physical	17671428
CDK2_HUMAN	CDK2	physical	17671428
CDK2_HUMAN	CDK2	physical	19622356
SKP2_HUMAN	SKP2	physical	19622356
CDK2_HUMAN	CDK2	physical	11980914
CLIP3_HUMAN	CLIP3	physical	26017671

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.