MIC26_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MIC26_HUMAN
• UniProt AC: Q9BUR5
• Protein Name: MICOS complex subunit MIC26 {ECO:0000303|PubMed:25764979}
• Gene Name: APOO
• Organism: Homo sapiens (Human).
• Sequence Length: 198
• Subcellular Localization: Mitochondrion inner membrane ; Single-pass membrane protein . Secreted . Mitochondrion . Golgi apparatus membrane . Endoplasmic reticulum membrane . Exists in three distinct forms: a glycosylated and secreted form, an ER/Golgi-resident form and a non
• Protein Description: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function. [PubMed: 25764979 Can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts]
• Protein Sequence: MFKVIQRSVGPASLSLLTFKVYAAPKKDSPPKNSVKVDELSLYSVPEGQSKYVEEARSQLEESISQLRHYCEPYTTWCQETYSQTKPKMQSLVQWGLDSYDYLQNAPPGFFPRLGVIGFAGLIGLLLARGSKIKKLVYPPGFMGLAASLYYPQQAIVFAQVSGERLYDWGLRGYIVIEDLWKENFQKPGNVKNSPGTK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MFKVIQRSVGPASLS CCCEECCCCCHHHHH		-
29	Phosphorylation	YAAPKKDSPPKNSVK EECCCCCCCCCCCEE		29214152
36	Ubiquitination	SPPKNSVKVDELSLY CCCCCCEEEEEEEEE		29967540
41	Phosphorylation	SVKVDELSLYSVPEG CEEEEEEEEEECCCC		22673903
43	Phosphorylation	KVDELSLYSVPEGQS EEEEEEEEECCCCHH		25884760
44	Phosphorylation	VDELSLYSVPEGQSK EEEEEEEECCCCHHH		21815630
50	Phosphorylation	YSVPEGQSKYVEEAR EECCCCHHHHHHHHH		22673903
51	Ubiquitination	SVPEGQSKYVEEARS ECCCCHHHHHHHHHH		29967540
58	Phosphorylation	KYVEEARSQLEESIS HHHHHHHHHHHHHHH		26437602
63	Phosphorylation	ARSQLEESISQLRHY HHHHHHHHHHHHHHH		24641631
65	Phosphorylation	SQLEESISQLRHYCE HHHHHHHHHHHHHHH		26437602
86	Acetylation	QETYSQTKPKMQSLV HHHHHCCCHHHHHHH		26051181
156	Ubiquitination	LYYPQQAIVFAQVSG CCCCCEEEEEEEECC		27667366
162	O-linked_Glycosylation	AIVFAQVSGERLYDW EEEEEEECCCCHHCC		-
192	Ubiquitination	FQKPGNVKNSPGTK- CCCCCCCCCCCCCC-		27667366
196	Ubiquitination	GNVKNSPGTK----- CCCCCCCCCC-----		27667366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MIC26_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MIC26_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MIC26_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MIC26_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.