STML1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STML1_HUMAN
• UniProt AC: Q9UBI4
• Protein Name: Stomatin-like protein 1
• Gene Name: STOML1
• Organism: Homo sapiens (Human).
• Sequence Length: 398
• Subcellular Localization: Membrane ; Single-pass type III membrane protein . Late endosome membrane . Membrane raft . Cell membrane ; Single-pass type III membrane protein. Cytoplasmic vesicle .
• Protein Description: May play a role in cholesterol transfer to late endosomes. [PubMed: 19696025 May play a role in modulating membrane acid-sensing ion channels. Can specifically inhibit proton-gated current of ASIC1 isoform 1. Can increase inactivation speed of ASIC3. May be involved in regulation of proton sensing in dorsal root ganglions (By similarity May play a role in protecting FBXW7 isoform 3 from degradation]
• Protein Sequence: MLGRSGYRALPLGDFDRFQQSSFGFLGSQKGCLSPERGGVGTGADVPQSWPSCLCHGLISFLGFLLLLVTFPISGWFALKIVPTYERMIVFRLGRIRTPQGPGMVLLLPFIDSFQRVDLRTRAFNVPPCKLASKDGAVLSVGADVQFRIWDPVLSVMTVKDLNTATRMTAQNAMTKALLKRPLREIQMEKLKISDQLLLEINDVTRAWGLEVDRVELAVEAVLQPPQDSPAGPNLDSTLQQLALHFLGGSMNSMAGGAPSPGPADTVEMVSEVEPPAPQVGARSSPKQPLAEGLLTALQPFLSEALVSQVGACYQFNVVLPSGTQSAYFLDLTTGRGRVGHGVPDGIPDVVVEMAEADLRALLCRELRPLGAYMSGRLKVKGDLAMAMKLEAVLRALK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	DFDRFQQSSFGFLGS CHHHHHHCCCCCCCC	19.49	28857561
22	Phosphorylation	FDRFQQSSFGFLGSQ HHHHHHCCCCCCCCC	25.67	28857561
28	Phosphorylation	SSFGFLGSQKGCLSP CCCCCCCCCCCCCCC	30.76	14702039
34	Phosphorylation	GSQKGCLSPERGGVG CCCCCCCCCCCCCCC	28.88	21712546
118	Ubiquitination	IDSFQRVDLRTRAFN CCCCCCCCCCCCCCC	32.40	-
134	Ubiquitination	PPCKLASKDGAVLSV CCCCCCCCCCCEEEE	55.35	-
140	Phosphorylation	SKDGAVLSVGADVQF CCCCCEEEECCCEEE	16.35	-
158	Phosphorylation	DPVLSVMTVKDLNTA CCEEEEEEHHCCCHH	23.42	-
160	Ubiquitination	VLSVMTVKDLNTATR EEEEEEHHCCCHHHH	47.54	-
169	Phosphorylation	LNTATRMTAQNAMTK CCHHHHHHHHHHHHH	23.08	29978859
175	Phosphorylation	MTAQNAMTKALLKRP HHHHHHHHHHHHHCC	15.68	29978859
176	Ubiquitination	TAQNAMTKALLKRPL HHHHHHHHHHHHCCH	24.77	-
205	Phosphorylation	LLEINDVTRAWGLEV HHHHHHHHHHHCCCC	19.96	-
284	Phosphorylation	APQVGARSSPKQPLA CCCCCCCCCCCCCHH	50.92	26699800
285	Phosphorylation	PQVGARSSPKQPLAE CCCCCCCCCCCCHHH	30.48	26699800
373	Phosphorylation	ELRPLGAYMSGRLKV HHHHCCCHHCCCCEE	7.04	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STML1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STML1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STML1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
FBXW7_HUMAN	FBXW7	physical	23082202
CDK2_HUMAN	CDK2	physical	23082202

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.