PHLA3_HUMAN - dbPTM
PHLA3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PHLA3_HUMAN
UniProt AC Q9Y5J5
Protein Name Pleckstrin homology-like domain family A member 3
Gene Name PHLDA3
Organism Homo sapiens (Human).
Sequence Length 127
Subcellular Localization Cytoplasm . Membrane
Peripheral membrane protein .
Protein Description p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor..
Protein Sequence MTAAATATVLKEGVLEKRSGGLLQLWKRKRCVLTERGLQLFEAKGTGGRPKELSFARIKAVECVESTGRHIYFTLVTEGGGEIDFRCPLEDPGWNAQITLGLVKFKNQQAIQTVRARQSLGTGTLVS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
11UbiquitinationAATATVLKEGVLEKR
HHHHHHHHHCHHHCC		48.3530230243
17UbiquitinationLKEGVLEKRSGGLLQ
HHHCHHHCCCCCHHH		47.94-
27UbiquitinationGGLLQLWKRKRCVLT
CCHHHHHCCCCEEEE		57.54-
44UbiquitinationGLQLFEAKGTGGRPK
HHHHEECCCCCCCCC		50.2130230243
51UbiquitinationKGTGGRPKELSFARI
CCCCCCCCEECEEEE		70.6729967540
59UbiquitinationELSFARIKAVECVES
EECEEEEEEEEEEHH		40.6030230243
106MethylationTLGLVKFKNQQAIQT
EEEEEEECCHHHHHH		48.40115974953
106UbiquitinationTLGLVKFKNQQAIQT
EEEEEEECCHHHHHH		48.4030230243
113PhosphorylationKNQQAIQTVRARQSL
CCHHHHHHHHHHHHH		13.0729514088
119PhosphorylationQTVRARQSLGTGTLV
HHHHHHHHHCCCCCC		24.1826055452
122PhosphorylationRARQSLGTGTLVS--
HHHHHHCCCCCCC--		32.0829514088
124PhosphorylationRQSLGTGTLVS----
HHHHCCCCCCC----		24.6729514088
127PhosphorylationLGTGTLVS-------
HCCCCCCC-------		37.3023090842
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PHLA3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PHLA3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PHLA3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DAAF5_HUMANDNAAF5physical
17353931
NUP93_HUMANNUP93physical
17353931
PDC6I_HUMANPDCD6IPphysical
17353931
TTC27_HUMANTTC27physical
17353931
NU205_HUMANNUP205physical
17353931
HNRPM_HUMANHNRNPMphysical
17353931
IPO4_HUMANIPO4physical
17353931
CMC1_HUMANSLC25A12physical
17353931
PDXD1_HUMANPDXDC1physical
17353931
LPPRC_HUMANLRPPRCphysical
17353931
ATP5L_HUMANATP5Lphysical
17353931
SSRD_HUMANSSR4physical
17353931
TNPO3_HUMANTNPO3physical
17353931
MMS19_HUMANMMS19physical
17353931
XPO5_HUMANXPO5physical
17353931
AHSA1_HUMANAHSA1physical
17353931
ZW10_HUMANZW10physical
17353931
XPO4_HUMANXPO4physical
17353931
U5S1_HUMANEFTUD2physical
17353931
CCD47_HUMANCCDC47physical
17353931
SYRM_HUMANRARS2physical
17353931
SMAP1_HUMANSMAP1physical
17353931
A4_HUMANAPPphysical
21832049
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PHLA3_HUMAN

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Related Literatures of Post-Translational Modification

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