| UniProt ID | SYRM_HUMAN | |
|---|---|---|
| UniProt AC | Q5T160 | |
| Protein Name | Probable arginine--tRNA ligase, mitochondrial | |
| Gene Name | RARS2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 578 | |
| Subcellular Localization | Mitochondrion matrix. | |
| Protein Description | ||
| Protein Sequence | MACGFRRAIACQLSRVLNLPPENLITSISAVPISQKEEVADFQLSVDSLLEKDNDHSRPDIQVQAKRLAEKLRCDTVVSEISTGQRTVNFKINRELLTKTVLQQVIEDGSKYGLKSELFSGLPQKKIVVEFSSPNVAKKFHVGHLRSTIIGNFIANLKEALGHQVIRINYLGDWGMQFGLLGTGFQLFGYEEKLQSNPLQHLFEVYVQVNKEAADDKSVAKAAQEFFQRLELGDVQALSLWQKFRDLSIEEYIRVYKRLGVYFDEYSGESFYREKSQEVLKLLESKGLLLKTIKGTAVVDLSGNGDPSSICTVMRSDGTSLYATRDLAAAIDRMDKYNFDTMIYVTDKGQKKHFQQVFQMLKIMGYDWAERCQHVPFGVVQGMKTRRGDVTFLEDVLNEIQLRMLQNMASIKTTKELKNPQETAERVGLAALIIQDFKGLLLSDYKFSWDRVFQSRGDTGVFLQYTHARLHSLEETFGCGYLNDFNTACLQEPQSVSILQHLLRFDEVLYKSSQDFQPRHIVSYLLTLSHLAAVAHKTLQIKDSPPEVAGARLHLFKAVRSVLANGMKLLGITPVCRM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 45 | Phosphorylation | EVADFQLSVDSLLEK HHHCEECCHHHHHHH | 17.07 | 29083192 | |
| 48 | Phosphorylation | DFQLSVDSLLEKDND CEECCHHHHHHHCCC | 32.47 | 24719451 | |
| 57 | O-linked_Glycosylation | LEKDNDHSRPDIQVQ HHHCCCCCCCCHHHH | 48.66 | 30379171 | |
| 66 | Ubiquitination | PDIQVQAKRLAEKLR CCHHHHHHHHHHHHC | 30.74 | - | |
| 99 | Ubiquitination | INRELLTKTVLQQVI ECHHHHHHHHHHHHH | 36.28 | - | |
| 112 | Phosphorylation | VIEDGSKYGLKSELF HHHCCHHCCCCHHHC | 29.41 | 28842319 | |
| 115 | Ubiquitination | DGSKYGLKSELFSGL CCHHCCCCHHHCCCC | 37.21 | 21890473 | |
| 116 | Phosphorylation | GSKYGLKSELFSGLP CHHCCCCHHHCCCCC | 44.57 | 28842319 | |
| 125 | Acetylation | LFSGLPQKKIVVEFS HCCCCCCCEEEEEEC | 42.39 | 25953088 | |
| 125 | 2-Hydroxyisobutyrylation | LFSGLPQKKIVVEFS HCCCCCCCEEEEEEC | 42.39 | - | |
| 138 | Acetylation | FSSPNVAKKFHVGHL ECCCCHHHHCCCHHH | 52.25 | 25953088 | |
| 138 | Succinylation | FSSPNVAKKFHVGHL ECCCCHHHHCCCHHH | 52.25 | 23954790 | |
| 138 | Malonylation | FSSPNVAKKFHVGHL ECCCCHHHHCCCHHH | 52.25 | 26320211 | |
| 139 | Acetylation | SSPNVAKKFHVGHLR CCCCHHHHCCCHHHH | 30.85 | 25953088 | |
| 221 | Malonylation | ADDKSVAKAAQEFFQ CCCHHHHHHHHHHHH | 41.94 | 26320211 | |
| 285 | Phosphorylation | EVLKLLESKGLLLKT HHHHHHHHCCCEEEE | 31.80 | 29396449 | |
| 312 | Phosphorylation | GDPSSICTVMRSDGT CCHHHCEEEECCCCC | 18.70 | 22210691 | |
| 346 | Phosphorylation | FDTMIYVTDKGQKKH CCEEEEECCCCCHHH | 18.28 | - | |
| 352 | Malonylation | VTDKGQKKHFQQVFQ ECCCCCHHHHHHHHH | 41.59 | 26320211 | |
| 362 | Acetylation | QQVFQMLKIMGYDWA HHHHHHHHHHCCCHH | 25.88 | 12655243 | |
| 410 | Phosphorylation | RMLQNMASIKTTKEL HHHHHHHCCCCHHHH | 17.53 | 30631047 | |
| 446 | Ubiquitination | GLLLSDYKFSWDRVF CHHHCCCCCCHHHHH | 37.60 | 21890473 | |
| 511 | Malonylation | RFDEVLYKSSQDFQP HHHHHHHHCCCCCCH | 39.20 | 26320211 | |
| 542 | Malonylation | AHKTLQIKDSPPEVA HHHHCCCCCCCHHHC | 38.91 | 26320211 | |
| 557 | Acetylation | GARLHLFKAVRSVLA HHHHHHHHHHHHHHH | 52.94 | 25953088 | |
| 568 | Acetylation | SVLANGMKLLGITPV HHHHHCHHHCCCCCC | 41.79 | - | |
| 573 | Phosphorylation | GMKLLGITPVCRM-- CHHHCCCCCCCCC-- | 14.10 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SYRM_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SYRM_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SYRM_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CPSM_HUMAN | CPS1 | physical | 26186194 | |
| AT12A_HUMAN | ATP12A | physical | 26186194 | |
| RRF2M_HUMAN | GFM2 | physical | 26186194 | |
| PREP_HUMAN | PITRM1 | physical | 26186194 | |
| GLSK_HUMAN | GLS | physical | 26186194 | |
| PDPR_HUMAN | PDPR | physical | 26186194 | |
| PCCA_HUMAN | PCCA | physical | 26186194 | |
| PPCEL_HUMAN | PREPL | physical | 26186194 | |
| PXDC2_HUMAN | PLXDC2 | physical | 26186194 | |
| MCCA_HUMAN | MCCC1 | physical | 26186194 | |
| CLN3_HUMAN | CLN3 | physical | 26186194 | |
| ARL8A_HUMAN | ARL8A | physical | 26186194 | |
| SYAM_HUMAN | AARS2 | physical | 26186194 | |
| NSDHL_HUMAN | NSDHL | physical | 26186194 | |
| RRF2M_HUMAN | GFM2 | physical | 28514442 | |
| AT12A_HUMAN | ATP12A | physical | 28514442 | |
| PREP_HUMAN | PITRM1 | physical | 28514442 | |
| PDPR_HUMAN | PDPR | physical | 28514442 | |
| CPSM_HUMAN | CPS1 | physical | 28514442 | |
| ARL8A_HUMAN | ARL8A | physical | 28514442 | |
| PCCA_HUMAN | PCCA | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 611523 | Pontocerebellar hypoplasia 6 (PCH6) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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