PPCEL_HUMAN - dbPTM
PPCEL_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PPCEL_HUMAN
UniProt AC Q4J6C6
Protein Name Prolyl endopeptidase-like
Gene Name PREPL
Organism Homo sapiens (Human).
Sequence Length 727
Subcellular Localization Cytoplasm, cytosol .
Protein Description Probable serine peptidase whose precise substrate specificity remains unclear. Does not cleave peptides after a arginine or lysine residue. May play a role in the regulation of synaptic vesiscle exocytosis. [PubMed: 24610330]
Protein Sequence MQQKTKLFLQALKYSIPHLGKCMQKQHLNHYNFADHCYNRIKLKKYHLTKCLQNKPKISELARNIPSRSFSCKDLQPVKQENEKPLPENMDAFEKVRTKLETQPQEEYEIINVEVKHGGFVYYQEGCCLVRSKDEEADNDNYEVLFNLEELKLDQPFIDCIRVAPDEKYVAAKIRTEDSEASTCVIIKLSDQPVMEASFPNVSSFEWVKDEEDEDVLFYTFQRNLRCHDVYRATFGDNKRNERFYTEKDPSYFVFLYLTKDSRFLTINIMNKTTSEVWLIDGLSPWDPPVLIQKRIHGVLYYVEHRDDELYILTNVGEPTEFKLMRTAADTPAIMNWDLFFTMKRNTKVIDLDMFKDHCVLFLKHSNLLYVNVIGLADDSVRSLKLPPWACGFIMDTNSDPKNCPFQLCSPIRPPKYYTYKFAEGKLFEETGHEDPITKTSRVLRLEAKSKDGKLVPMTVFHKTDSEDLQKKPLLVHVYGAYGMDLKMNFRPERRVLVDDGWILAYCHVRGGGELGLQWHADGRLTKKLNGLADLEACIKTLHGQGFSQPSLTTLTAFSAGGVLAGALCNSNPELVRAVTLEAPFLDVLNTMMDTTLPLTLEELEEWGNPSSDEKHKNYIKRYCPYQNIKPQHYPSIHITAYENDERVPLKGIVSYTEKLKEAIAEHAKDTGEGYQTPNIILDIQPGGNHVIEDSHKKITAQIKFLYEELGLDSTSVFEDLKKYLKF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1 (in isoform 4)Acetylation-9.5722814378
5Phosphorylation---MQQKTKLFLQAL
---CCHHHHHHHHHH		28.7424043423
6Ubiquitination--MQQKTKLFLQALK
--CCHHHHHHHHHHH		44.2530230243
59PhosphorylationLQNKPKISELARNIP
HHCCHHHHHHHHCCC		32.4626074081
63MethylationPKISELARNIPSRSF
HHHHHHHHCCCCCCC		54.9924383555
63UbiquitinationPKISELARNIPSRSF
HHHHHHHHCCCCCCC		54.9921963094
67PhosphorylationELARNIPSRSFSCKD
HHHHCCCCCCCCCCC		36.4426074081
69PhosphorylationARNIPSRSFSCKDLQ
HHCCCCCCCCCCCCC		26.3326074081
71PhosphorylationNIPSRSFSCKDLQPV
CCCCCCCCCCCCCCC		22.8526074081
79UbiquitinationCKDLQPVKQENEKPL
CCCCCCCCCCCCCCC		59.5929967540
84UbiquitinationPVKQENEKPLPENMD
CCCCCCCCCCCCCHH		64.5324816145
95UbiquitinationENMDAFEKVRTKLET
CCHHHHHHHHHHHHC		30.4823000965
99AcetylationAFEKVRTKLETQPQE
HHHHHHHHHHCCCCC		33.4925953088
99UbiquitinationAFEKVRTKLETQPQE
HHHHHHHHHHCCCCC		33.4923000965
108PhosphorylationETQPQEEYEIINVEV
HCCCCCEEEEEEEEE		16.2127642862
152UbiquitinationLFNLEELKLDQPFID
EEEHHHHCCCCCEEE		53.9821963094
168UbiquitinationIRVAPDEKYVAAKIR
EEECCCCCEEEEEEE		53.0229967540
169PhosphorylationRVAPDEKYVAAKIRT
EECCCCCEEEEEEEC		8.0223322592
173UbiquitinationDEKYVAAKIRTEDSE
CCCEEEEEEECCCCC		24.0024816145
179PhosphorylationAKIRTEDSEASTCVI
EEEECCCCCCCEEEE		28.9123322592
183PhosphorylationTEDSEASTCVIIKLS
CCCCCCCEEEEEECC		20.1723322592
262PhosphorylationFLYLTKDSRFLTINI
EEEEECCCCEEEEEE		26.87-
266PhosphorylationTKDSRFLTINIMNKT
ECCCCEEEEEEECCC		14.85-
327PhosphorylationTEFKLMRTAADTPAI
CCEECHHHCCCCCCC		16.5426552605
331PhosphorylationLMRTAADTPAIMNWD
CHHHCCCCCCCCCEE		15.1922210691
332UbiquitinationMRTAADTPAIMNWDL
HHHCCCCCCCCCEEE		21.9722817900
337 (in isoform 4)Ubiquitination-6.0621890473
337UbiquitinationDTPAIMNWDLFFTMK
CCCCCCCEEEEEEEC		6.0622817900
342PhosphorylationMNWDLFFTMKRNTKV
CCEEEEEEECCCCEE		17.9126552605
347PhosphorylationFFTMKRNTKVIDLDM
EEEECCCCEEEEHHH		30.6222210691
350UbiquitinationMKRNTKVIDLDMFKD
ECCCCEEEEHHHHCC		4.6733845483
350 (in isoform 4)Ubiquitination-4.6721890473
359UbiquitinationLDMFKDHCVLFLKHS
HHHHCCCEEEEECCC		4.0022817900
364 (in isoform 3)Ubiquitination-37.3421890473
364UbiquitinationDHCVLFLKHSNLLYV
CCEEEEECCCCEEEE		37.3422817900
366PhosphorylationCVLFLKHSNLLYVNV
EEEEECCCCEEEEEE		27.8228122231
370PhosphorylationLKHSNLLYVNVIGLA
ECCCCEEEEEEEEEC		7.9828122231
377UbiquitinationYVNVIGLADDSVRSL
EEEEEEECCCCHHCC		17.2233845483
377 (in isoform 3)Ubiquitination-17.2221890473
383PhosphorylationLADDSVRSLKLPPWA
ECCCCHHCCCCCCCE		27.92-
410PhosphorylationNCPFQLCSPIRPPKY
CCCCCCCCCCCCCCE		31.7720873877
421UbiquitinationPPKYYTYKFAEGKLF
CCCEEEEEEECCCEE		30.2322817900
426AcetylationTYKFAEGKLFEETGH
EEEEECCCEECCCCC		41.3223954790
426 (in isoform 1)Ubiquitination-41.3221890473
426UbiquitinationTYKFAEGKLFEETGH
EEEEECCCEECCCCC		41.3222817900
439UbiquitinationGHEDPITKTSRVLRL
CCCCCCCCHHHEEEE		45.2622817900
439AcetylationGHEDPITKTSRVLRL
CCCCCCCCHHHEEEE		45.2626051181
439 (in isoform 1)Ubiquitination-45.2621890473
440PhosphorylationHEDPITKTSRVLRLE
CCCCCCCHHHEEEEE		17.0820068231
441PhosphorylationEDPITKTSRVLRLEA
CCCCCCHHHEEEEEE		23.1920068231
459PhosphorylationDGKLVPMTVFHKTDS
CCCEEEEEEEECCCC		17.6026503514
479PhosphorylationKPLLVHVYGAYGMDL
CCEEEEEEEECCCCC		4.9119664995
562UbiquitinationLTAFSAGGVLAGALC
EEEECCCCHHHHHHH		15.8132142685
572UbiquitinationAGALCNSNPELVRAV
HHHHHCCCHHHHHEE		21.7729967540
585UbiquitinationAVTLEAPFLDVLNTM
EEEECCCHHHHHHHH		13.5032142685
589UbiquitinationEAPFLDVLNTMMDTT
CCCHHHHHHHHHHCC		4.3932142685
595UbiquitinationVLNTMMDTTLPLTLE
HHHHHHHCCCCCCHH		16.6129967540
599UbiquitinationMMDTTLPLTLEELEE
HHHCCCCCCHHHHHH		10.8429967540
633UbiquitinationYQNIKPQHYPSIHIT
CCCCCCCCCCEEEEE		45.0232015554
651UbiquitinationNDERVPLKGIVSYTE
CCCCCCCCCEECCHH		40.2932142685
656UbiquitinationPLKGIVSYTEKLKEA
CCCCEECCHHHHHHH		14.1832015554
660UbiquitinationIVSYTEKLKEAIAEH
EECCHHHHHHHHHHH		5.0232015554
661UbiquitinationVSYTEKLKEAIAEHA
ECCHHHHHHHHHHHH		57.0529967540
698AcetylationVIEDSHKKITAQIKF
CCCCCCHHHHHHHHH		39.6112439199
704AcetylationKKITAQIKFLYEELG
HHHHHHHHHHHHHHC		19.7512439209
722UbiquitinationTSVFEDLKKYLKF--
CHHHHHHHHHHCC--		52.2532015554
722AcetylationTSVFEDLKKYLKF--
CHHHHHHHHHHCC--		52.2524431315
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PPCEL_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PPCEL_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PPCEL_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PPCEL_HUMANPREPLphysical
27499296
AATM_HUMANGOT2physical
27499296
MPPA_HUMANPMPCAphysical
27499296
C1QBP_HUMANC1QBPphysical
27499296
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
606407Hypotonia-cystinuria syndrome (HCS)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PPCEL_HUMAN

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Related Literatures of Post-Translational Modification

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