CP2S1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CP2S1_HUMAN
• UniProt AC: Q96SQ9
• Protein Name: Cytochrome P450 2S1
• Gene Name: CYP2S1
• Organism: Homo sapiens (Human).
• Sequence Length: 504
• Subcellular Localization: Endoplasmic reticulum membrane ; Peripheral membrane protein . Microsome membrane ; Peripheral membrane protein .
• Protein Description: Has a potential importance for extrahepatic xenobiotic metabolism..
• Protein Sequence: MEATGTWALLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRLSKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSNGERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHVSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSGLFNIPPAFQLQVRPTDLHSTTQTR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MEATGTWALLL ----CCCHHHHHHHH	23.10	24043423
6	Phosphorylation	--MEATGTWALLLAL --CCCHHHHHHHHHH	11.83	24043423
20	Phosphorylation	LALLLLLTLALSGTR HHHHHHHHHHHHCCC	15.23	24043423
24	Phosphorylation	LLLTLALSGTRARGH HHHHHHHHCCCCCCC	32.29	24043423
26	Phosphorylation	LTLALSGTRARGHLP HHHHHHCCCCCCCCC	20.13	24043423
37	Phosphorylation	GHLPPGPTPLPLLGN CCCCCCCCCCHHHHH	43.29	-
54	Phosphorylation	QLRPGALYSGLMRLS HCCCCCHHHHHHHHH	10.52	-
55	Phosphorylation	LRPGALYSGLMRLSK CCCCCHHHHHHHHHH	26.71	-
61	Phosphorylation	YSGLMRLSKKYGPVF HHHHHHHHHHHCCEE	19.41	-
129	Acetylation	ERWRQLRKFTMLALR HHHHHHHHHHHHHHH	54.50	19812073
131	Phosphorylation	WRQLRKFTMLALRDL HHHHHHHHHHHHHHC	17.82	24825855
142	2-Hydroxyisobutyrylation	LRDLGMGKREGEELI HHHCCCCCHHHHHHH	38.08	-
295	Phosphorylation	TNKNMLMTVIYLLFA CCHHHHHHHHHHHHH	10.37	-
374	Phosphorylation	VPMGIPRTLMRTTRF HCCCCCHHHHHHCCC	21.39	-
378	Phosphorylation	IPRTLMRTTRFRGYT CCHHHHHHCCCCCEE	14.36	-
379	Phosphorylation	PRTLMRTTRFRGYTL CHHHHHHCCCCCEEC	19.90	-
426	Ubiquitination	DADGRFRKHEAFLPF CCCCCCCCCCCCCCC	42.98	33845483
437	Ubiquitination	FLPFSLGKRVCLGEG CCCCCCCCCCCCCCC	47.12	33845483
499	Phosphorylation	VRPTDLHSTTQTR-- ECCCCCCCCCCCC--	40.21	23312004
500	Phosphorylation	RPTDLHSTTQTR--- CCCCCCCCCCCC---	16.51	23312004
501	Phosphorylation	PTDLHSTTQTR---- CCCCCCCCCCC----	30.84	23312004
503	Phosphorylation	DLHSTTQTR------ CCCCCCCCC------	35.93	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CP2S1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CP2S1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CP2S1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATL4_HUMAN	ADAMTSL4	physical	25416956
ATL4_HUMAN	ADAMTSL4	physical	21516116
CADM4_HUMAN	CADM4	physical	28514442
KPCA_HUMAN	PRKCA	physical	28514442
PHAG1_HUMAN	PAG1	physical	28514442
SRC_HUMAN	SRC	physical	28514442
HXB9_HUMAN	HOXB9	physical	28514442
NCAM1_HUMAN	NCAM1	physical	28514442
RASH_HUMAN	HRAS	physical	28514442
MPP6_HUMAN	MPP6	physical	28514442
EPHA2_HUMAN	EPHA2	physical	28514442
ARVC_HUMAN	ARVCF	physical	28514442
TRXR2_HUMAN	TXNRD2	physical	28514442
RGS19_HUMAN	RGS19	physical	28514442
KC1G3_HUMAN	CSNK1G3	physical	28514442
GNA13_HUMAN	GNA13	physical	28514442
MPP2_HUMAN	MPP2	physical	28514442
YES_HUMAN	YES1	physical	28514442
MPZL1_HUMAN	MPZL1	physical	28514442
E41L2_HUMAN	EPB41L2	physical	28514442
RAP2A_HUMAN	RAP2A	physical	28514442
EFNA5_HUMAN	EFNA5	physical	28514442
CXAR_HUMAN	CXADR	physical	28514442
GRIN1_HUMAN	GPRIN1	physical	28514442
E41L3_HUMAN	EPB41L3	physical	28514442
NEUM_HUMAN	GAP43	physical	28514442
ASM3B_HUMAN	SMPDL3B	physical	28514442
GBB4_HUMAN	GNB4	physical	28514442
CDCA3_HUMAN	CDCA3	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.