RABP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RABP1_HUMAN
• UniProt AC: P29762
• Protein Name: Cellular retinoic acid-binding protein 1
• Gene Name: CRABP1
• Organism: Homo sapiens (Human).
• Sequence Length: 137
• Subcellular Localization: Cytoplasm .
• Protein Description: Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors..
• Protein Sequence: MPNFAGTWKMRSSENFDELLKALGVNAMLRKVAVAAASKPHVEIRQDGDQFYIKTSTTVRTTEINFKVGEGFEEETVDGRKCRSLATWENENKIHCTQTLLEGDGPKTYWTRELANDELILTFGADDVVCTRIYVRE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	AGTWKMRSSENFDEL CCCCCCCCCCCHHHH	38.21	21406692
13	Phosphorylation	GTWKMRSSENFDELL CCCCCCCCCCHHHHH	26.62	21406692
21	Ubiquitination	ENFDELLKALGVNAM CCHHHHHHHHCHHHH	54.94	-
31	Ubiquitination	GVNAMLRKVAVAAAS CHHHHHHHHHHHHHC	30.50	-
38	Phosphorylation	KVAVAAASKPHVEIR HHHHHHHCCCCEEEE	41.83	17192257
62	Phosphorylation	TSTTVRTTEINFKVG ECCEEEEEEEEEEEC	25.05	27251275
97	Phosphorylation	NENKIHCTQTLLEGD CCCCEEEEEEEECCC	15.49	27251275
99	Phosphorylation	NKIHCTQTLLEGDGP CCEEEEEEEECCCCC	18.37	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RABP1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RABP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RABP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRA2A_HUMAN	TRA2A	physical	21900206

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00523: Alitretinoin
• DB00755: Tretinoin

Related Literatures of Post-Translational Modification

Phosphorylation

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-38, AND MASSSPECTROMETRY.
PubMed: 18691976