dbPTM

CDK15_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CDK15_HUMAN
UniProt AC	Q96Q40
Protein Name	Cyclin-dependent kinase 15
Gene Name	CDK15
Organism	Homo sapiens (Human).
Sequence Length	435
Subcellular Localization
Protein Description	Serine/threonine-protein kinase that acts like an antiapoptotic protein that counters TRAIL/TNFSF10-induced apoptosis by inducing phosphorylation of BIRC5 at 'Thr-34'..
Protein Sequence	MGQELCAKTVQPGCSCYHCSEGGEAHSCRRSQPETTEAAFKLTDLKEASCSMTSFHPRGLQAARAQKFKSKRPRSNSDCFQEEDLRQGFQWRKSLPFGAASSYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGLKHANIVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQLPDEESLFTVSGVRLKPEMCDLLASYQKGHHPAQFSKCW

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35	Phosphorylation	CRRSQPETTEAAFKL CCCCCCCCHHHHHHH	36.30	28122231
36	Ubiquitination	RRSQPETTEAAFKLT CCCCCCCHHHHHHHH	23.20	22817900
36	Phosphorylation	RRSQPETTEAAFKLT CCCCCCCHHHHHHHH	23.20	28122231
46	Ubiquitination	AFKLTDLKEASCSMT HHHHHHHHHHCCCCC	54.78	22817900
75	Phosphorylation	FKSKRPRSNSDCFQE HHCCCCCCCCCCCCH	43.28	27251789
77	Phosphorylation	SKRPRSNSDCFQEED CCCCCCCCCCCCHHH	36.68	27251789
113	Phosphorylation	LEKLGEGSYATVYKG HHHHCCCCCEEHHHC	13.80	20071362
114	Phosphorylation	EKLGEGSYATVYKGI HHHCCCCCEEHHHCH	19.69	25884760
118	Phosphorylation	EGSYATVYKGISRIN CCCCEEHHHCHHHCC	10.11	17016520
151	Phosphorylation	FTAIREASLLKGLKH HHHHHHHHHHCCCHH	29.49	24719451
170	Phosphorylation	LLHDIIHTKETLTFV EEEEHHHCHHHHHHH	21.84	-
175	Ubiquitination	IHTKETLTFVFEYMH HHCHHHHHHHHHHHH	25.77	22817900
188	Ubiquitination	MHTDLAQYMSQHPGG HHHHHHHHHHHCCCC	7.98	30230243
199	Phosphorylation	HPGGLHPHNVRLFMF CCCCCCHHHHHHHHH	34.37	24719451
202	Phosphorylation	GLHPHNVRLFMFQLL CCCHHHHHHHHHHHH	27.76	24719451
226	Ubiquitination	HVLHRDLKPQNLLIS HHHCCCCCHHHEEEH	49.17	22817900
239	Ubiquitination	ISHLGELKLADFGLA EHHCCHHHHHHHCCC	37.01	30230243
250	Phosphorylation	FGLARAKSIPSQTYS HCCCCCCCCCCCCCC	38.45	24719451
253	Phosphorylation	ARAKSIPSQTYSSEV CCCCCCCCCCCCCEE	33.22	24719451
257	Phosphorylation	SIPSQTYSSEVVTLW CCCCCCCCCEEEEEE	24.34	22617229
265	Phosphorylation	SEVVTLWYRPPDALL CEEEEEEECCCCHHC	19.16	22617229
321	Phosphorylation	WEVLGVPTEDTWPGV HHHHCCCCCCCCCCC	44.05	27251275
324	Phosphorylation	LGVPTEDTWPGVSKL HCCCCCCCCCCCCCC	27.59	27251275
329	Phosphorylation	EDTWPGVSKLPNYNP CCCCCCCCCCCCCCC	34.10	27251275
334	Phosphorylation	GVSKLPNYNPEWFPL CCCCCCCCCCCCCCC	30.10	27251275
343	Phosphorylation	PEWFPLPTPRSLHVV CCCCCCCCCCHHHHH	38.73	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CDK15_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CDK15_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CDK15_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FKBP5_HUMAN	FKBP5	physical	23602568
AFF4_HUMAN	AFF4	physical	23602568
NDUA4_HUMAN	NDUFA4	physical	23602568
ATD3B_HUMAN	ATAD3B	physical	23602568
PLAK_HUMAN	JUP	physical	23602568
RBM14_HUMAN	RBM14	physical	23602568
ROCK1_HUMAN	ROCK1	physical	23602568
NOP58_HUMAN	NOP58	physical	23602568
HS90A_HUMAN	HSP90AA1	physical	26186194
HS90B_HUMAN	HSP90AB1	physical	26186194
TCPW_HUMAN	CCT6B	physical	26186194
TCPB_HUMAN	CCT2	physical	26186194
FKBP5_HUMAN	FKBP5	physical	26186194
CDC37_HUMAN	CDC37	physical	26186194
TCPD_HUMAN	CCT4	physical	26186194
PHLP_HUMAN	PDCL	physical	26186194
MARK2_HUMAN	MARK2	physical	26186194
AXA81_HUMAN	ANXA8L1	physical	28514442
S1A7A_HUMAN	S100A7A	physical	28514442
NIBL1_HUMAN	FAM129B	physical	28514442
RDHE2_HUMAN	SDR16C5	physical	28514442
PEPL_HUMAN	PPL	physical	28514442
ST2B1_HUMAN	SULT2B1	physical	28514442
TYPH_HUMAN	TYMP	physical	28514442
ASC_HUMAN	PYCARD	physical	28514442
TREX2_HUMAN	TREX2	physical	28514442
EVPL_HUMAN	EVPL	physical	28514442
AL1A3_HUMAN	ALDH1A3	physical	28514442
RHG01_HUMAN	ARHGAP1	physical	28514442
ACP7_HUMAN	PAPL	physical	28514442
FKBP5_HUMAN	FKBP5	physical	28514442
NDRG2_HUMAN	NDRG2	physical	28514442
CO3_HUMAN	C3	physical	28514442
TMM40_HUMAN	TMEM40	physical	28514442
FCSD1_HUMAN	FCHSD1	physical	28514442
TRI25_HUMAN	TRIM25	physical	28514442
TRI29_HUMAN	TRIM29	physical	28514442
RABP2_HUMAN	CRABP2	physical	28514442
SPB7_HUMAN	SERPINB7	physical	28514442
SPB4_HUMAN	SERPINB4	physical	28514442
INVO_HUMAN	IVL	physical	28514442
HMCS1_HUMAN	HMGCS1	physical	28514442
STAT3_HUMAN	STAT3	physical	28514442
ANR22_HUMAN	ANKRD22	physical	28514442
I36RA_HUMAN	IL36RN	physical	28514442
SQOR_HUMAN	SQRDL	physical	28514442
ILEU_HUMAN	SERPINB1	physical	28514442
ENDOU_HUMAN	ENDOU	physical	28514442
SPB5_HUMAN	SERPINB5	physical	28514442
AK1BA_HUMAN	AKR1B10	physical	28514442
KLK7_HUMAN	KLK7	physical	28514442
PPAP_HUMAN	ACPP	physical	28514442
NDRG1_HUMAN	NDRG1	physical	28514442
PA24E_HUMAN	PLA2G4E	physical	28514442
KLK10_HUMAN	KLK10	physical	28514442
ES8L1_HUMAN	EPS8L1	physical	28514442
POF1B_HUMAN	POF1B	physical	28514442
HUTH_HUMAN	HAL	physical	28514442
CALL5_HUMAN	CALML5	physical	28514442
IL1RA_HUMAN	IL1RN	physical	28514442
CRBG1_HUMAN	AIM1	physical	28514442
SBSN_HUMAN	SBSN	physical	28514442
HS90A_HUMAN	HSP90AA1	physical	28514442
PKP3_HUMAN	PKP3	physical	28514442
FIBG_HUMAN	FGG	physical	28514442
ZN185_HUMAN	ZNF185	physical	28514442
PSME2_HUMAN	PSME2	physical	28514442
EPIPL_HUMAN	EPPK1	physical	28514442
CAPG_HUMAN	CAPG	physical	28514442
SPB8_HUMAN	SERPINB8	physical	28514442
SPB3_HUMAN	SERPINB3	physical	28514442
H2AY_HUMAN	H2AFY	physical	28514442
MAOX_HUMAN	ME1	physical	28514442
IL36G_HUMAN	IL36G	physical	28514442
TRFL_HUMAN	LTF	physical	28514442
RAB25_HUMAN	RAB25	physical	28514442
HMOX1_HUMAN	HMOX1	physical	28514442
CBPA4_HUMAN	CPA4	physical	28514442
RNAS7_HUMAN	RNASE7	physical	28514442
ZO2_HUMAN	TJP2	physical	28514442
SYNC_HUMAN	NARS	physical	28514442
A1AG1_HUMAN	ORM1	physical	28514442
S10A7_HUMAN	S100A7	physical	28514442
TGM1_HUMAN	TGM1	physical	28514442
IQGA1_HUMAN	IQGAP1	physical	28514442
PSME1_HUMAN	PSME1	physical	28514442
IL18_HUMAN	IL18	physical	28514442
CALL3_HUMAN	CALML3	physical	28514442
TGM3_HUMAN	TGM3	physical	28514442
FBX50_HUMAN	NCCRP1	physical	28514442
UD19_HUMAN	UGT1A9	physical	28514442
AACT_HUMAN	SERPINA3	physical	28514442
DESP_HUMAN	DSP	physical	28514442
ABC3A_HUMAN	APOBEC3A	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00171	Adenosine triphosphate

Regulatory Network of CDK15_HUMAN

Related Literatures of Post-Translational Modification