ZN185_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN185_HUMAN
• UniProt AC: O15231
• Protein Name: Zinc finger protein 185
• Gene Name: ZNF185
• Organism: Homo sapiens (Human).
• Sequence Length: 689
• Subcellular Localization: Cytoplasm, cytoskeleton . Cell junction, focal adhesion .
• Protein Description: May be involved in the regulation of cellular proliferation and/or differentiation..
• Protein Sequence: MSISALGGRTKGKPLPPGEEERNNVLKQMKVRTTLKGDKSWITKQDESEGRTIELPSGRSRATSFSSAGEVPKPRPPSTRAPTGYIIRGVFTKPIDSSSQPQQQFPKANGTPKSAASLVRTANAGPPRPSSSGYKMTTEDYKKLAPYNIRRSSTSGDTEEEEEEEVVPFSSDEQKRRSEAASGVLRRTAPREHSYVLSAAKKSTGPTQETQAPFIAKRVEVVEEDGPSEKSQDPPALARSTPGSNSADGGRTKASRAIWIECLPSMPSPAGSQELSSRGEEIVRLQILTPRAGLRLVAPDVEGMRSSPGNKDKEAPCSRELQRDLAGEEAFRAPNTDAARSSAQLSDGNVGSGATGSRPEGLAAVDIGSERGSSSATSVSAVPADRKSNSTAAQEDAKADPKGALADYEGKDVATRVGEAWQERPGAPRGGQGDPAVPAQQPADPSTPERQSSPSGSEQLVRRESCGSSVLTDFEGKDVATKVGEAWQDRPGAPRGGQGDPAVPTQQPADPSTPEQQNSPSGSEQFVRRESCTSRVRSPSSCMVTVTVTATSEQPHIYIPAPASELDSSSTTKGILFVKEYVNASEVSSGKPVSARYSNVSSIEDSFAMEKKPPCGSTPYSERTTGGICTYCNREIRDCPKITLEHLGICCHEYCFKCGICSKPMGDLLDQIFIHRDTIHCGKCYEKLF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSISALGGR ------CCCCCCCCC	25.83	25849741
4	Phosphorylation	----MSISALGGRTK ----CCCCCCCCCCC	15.33	21406692
13 (in isoform 9)	Phosphorylation	-	44.96	25159151
39 (in isoform 9)	Phosphorylation	-	57.25	24719451
42 (in isoform 5)	Phosphorylation	-	4.44	25849741
43 (in isoform 5)	Phosphorylation	-	19.18	28355574
45 (in isoform 5)	Phosphorylation	-	51.56	25849741
48	Phosphorylation	WITKQDESEGRTIEL CEEECCCCCCCEEEC	54.35	24043423
52	Phosphorylation	QDESEGRTIELPSGR CCCCCCCEEECCCCC	29.65	24043423
57	Phosphorylation	GRTIELPSGRSRATS CCEEECCCCCCCCCC	60.51	25849741
60	Phosphorylation	IELPSGRSRATSFSS EECCCCCCCCCCCCC	29.77	30266825
63	Phosphorylation	PSGRSRATSFSSAGE CCCCCCCCCCCCCCC	29.24	27273156
63 (in isoform 2)	Phosphorylation	-	29.24	30266825
64	Phosphorylation	SGRSRATSFSSAGEV CCCCCCCCCCCCCCC	23.34	30266825
64 (in isoform 6)	Phosphorylation	-	23.34	27251275
64 (in isoform 2)	Phosphorylation	-	23.34	30266825
66	Phosphorylation	RSRATSFSSAGEVPK CCCCCCCCCCCCCCC	21.03	30266825
66 (in isoform 6)	Phosphorylation	-	21.03	27251275
66 (in isoform 2)	Phosphorylation	-	21.03	30266825
67	Phosphorylation	SRATSFSSAGEVPKP CCCCCCCCCCCCCCC	37.98	28152594
68 (in isoform 2)	Phosphorylation	-	19.57	30266825
71 (in isoform 2)	Phosphorylation	-	7.85	23403867
78	Phosphorylation	VPKPRPPSTRAPTGY CCCCCCCCCCCCCCE	32.96	30266825
78 (in isoform 5)	Phosphorylation	-	32.96	27794612
79	O-linked_Glycosylation	PKPRPPSTRAPTGYI CCCCCCCCCCCCCEE	36.30	30379171
79	Phosphorylation	PKPRPPSTRAPTGYI CCCCCCCCCCCCCEE	36.30	30266825
79 (in isoform 5)	Phosphorylation	-	36.30	27794612
82 (in isoform 5)	Phosphorylation	-	24.06	25849741
85 (in isoform 6)	Phosphorylation	-	8.82	27642862
85 (in isoform 5)	Phosphorylation	-	8.82	28985074
86 (in isoform 5)	Phosphorylation	-	1.51	25849741
93	Acetylation	IIRGVFTKPIDSSSQ EEEEEEECCCCCCCC	28.63	23236377
102 (in isoform 2)	Phosphorylation	-	41.91	22985185
114	O-linked_Glycosylation	KANGTPKSAASLVRT CCCCCCHHHHHHHHH	30.21	30379171
117	Phosphorylation	GTPKSAASLVRTANA CCCHHHHHHHHHHCC	27.41	24719451
117 (in isoform 6)	Phosphorylation	-	27.41	27251275
121	Phosphorylation	SAASLVRTANAGPPR HHHHHHHHHCCCCCC	19.45	-
130	Phosphorylation	NAGPPRPSSSGYKMT CCCCCCCCCCCCCCC	38.11	27794612
131 (in isoform 6)	Phosphorylation	-	30.39	27251275
131	Phosphorylation	AGPPRPSSSGYKMTT CCCCCCCCCCCCCCH	30.39	25849741
132	Phosphorylation	GPPRPSSSGYKMTTE CCCCCCCCCCCCCHH	50.94	27794612
134	Phosphorylation	PRPSSSGYKMTTEDY CCCCCCCCCCCHHHH	10.26	-
141	Phosphorylation	YKMTTEDYKKLAPYN CCCCHHHHHHHHCCC	12.09	-
147	Phosphorylation	DYKKLAPYNIRRSST HHHHHHCCCCCCCCC	20.02	27273156
152	Phosphorylation	APYNIRRSSTSGDTE HCCCCCCCCCCCCCC	28.28	23401153
153	Phosphorylation	PYNIRRSSTSGDTEE CCCCCCCCCCCCCCC	25.44	27273156
153 (in isoform 6)	Phosphorylation	-	25.44	27251275
154	Phosphorylation	YNIRRSSTSGDTEEE CCCCCCCCCCCCCCH	37.67	27273156
154 (in isoform 6)	Phosphorylation	-	37.67	27251275
155	Phosphorylation	NIRRSSTSGDTEEEE CCCCCCCCCCCCCHH	36.30	26503892
158	Phosphorylation	RSSTSGDTEEEEEEE CCCCCCCCCCHHHHC	49.15	26503892
158 (in isoform 6)	Phosphorylation	-	49.15	27251275
170	Phosphorylation	EEEVVPFSSDEQKRR HHCCCCCCHHHHHHH	30.70	23403867
171	Phosphorylation	EEVVPFSSDEQKRRS HCCCCCCHHHHHHHH	45.61	23403867
178	Phosphorylation	SDEQKRRSEAASGVL HHHHHHHHHHHHHHH	35.30	28348404
188	Phosphorylation	ASGVLRRTAPREHSY HHHHHHHHCCCCCHH	34.28	28555341
194 (in isoform 6)	Phosphorylation	-	16.51	27251275
194	Phosphorylation	RTAPREHSYVLSAAK HHCCCCCHHHHHHHH	16.51	30087585
195	Phosphorylation	TAPREHSYVLSAAKK HCCCCCHHHHHHHHH	13.81	25394399
195 (in isoform 6)	Phosphorylation	-	13.81	27642862
198	Phosphorylation	REHSYVLSAAKKSTG CCCHHHHHHHHHCCC	19.01	28674419
203	Phosphorylation	VLSAAKKSTGPTQET HHHHHHHCCCCCHHC	37.58	-
203 (in isoform 3)	Phosphorylation	-	37.58	30266825
204	Phosphorylation	LSAAKKSTGPTQETQ HHHHHHCCCCCHHCC	56.94	28555341
204 (in isoform 3)	Phosphorylation	-	56.94	30266825
206 (in isoform 3)	Phosphorylation	-	30.88	30266825
208 (in isoform 3)	Phosphorylation	-	55.67	30266825
211 (in isoform 3)	Phosphorylation	-	46.41	23403867
215	Phosphorylation	QETQAPFIAKRVEVV HHCCCCCEEEEEEEE	4.26	18088087
221	Phosphorylation	FIAKRVEVVEEDGPS CEEEEEEEEECCCCC	6.33	18088087
228 (in isoform 6)	Phosphorylation	-	64.29	27251275
228	Phosphorylation	VVEEDGPSEKSQDPP EEECCCCCHHCCCCC	64.29	28348404
229	Ubiquitination	VEEDGPSEKSQDPPA EECCCCCHHCCCCCC	60.92	21890473
230	Acetylation	EEDGPSEKSQDPPAL ECCCCCHHCCCCCCH	58.73	23236377
231	Phosphorylation	EDGPSEKSQDPPALA CCCCCHHCCCCCCHH	35.45	24247654
232	Ubiquitination	DGPSEKSQDPPALAR CCCCHHCCCCCCHHC	77.59	-
240 (in isoform 4)	Phosphorylation	-	33.09	27794612
241 (in isoform 4)	Phosphorylation	-	26.56	27794612
244	Phosphorylation	LARSTPGSNSADGGR HHCCCCCCCCCCCCC	28.90	28102081
244 (in isoform 4)	Phosphorylation	-	28.90	25849741
246	Phosphorylation	RSTPGSNSADGGRTK CCCCCCCCCCCCCCC	29.45	28102081
247 (in isoform 4)	Phosphorylation	-	24.58	28985074
248 (in isoform 4)	Phosphorylation	-	60.96	25849741
265	Phosphorylation	IWIECLPSMPSPAGS EEEEECCCCCCCCCC	30.31	23879269
265 (in isoform 7)	Phosphorylation	-	30.31	23090842
265 (in isoform 8)	Phosphorylation	-	30.31	23090842
268 (in isoform 6)	Phosphorylation	-	20.81	27251275
268	Phosphorylation	ECLPSMPSPAGSQEL EECCCCCCCCCCHHH	20.81	24114839
268 (in isoform 7)	Phosphorylation	-	20.81	23090842
268 (in isoform 8)	Phosphorylation	-	20.81	23090842
272 (in isoform 8)	Phosphorylation	-	23.69	22617229
272	Phosphorylation	SMPSPAGSQELSSRG CCCCCCCCHHHHHCC	23.69	24114839
272 (in isoform 7)	Phosphorylation	-	23.69	22617229
276	Phosphorylation	PAGSQELSSRGEEIV CCCCHHHHHCCCEEE	19.75	24114839
277	Phosphorylation	AGSQELSSRGEEIVR CCCHHHHHCCCEEEE	57.86	24114839
277 (in isoform 7)	Phosphorylation	-	57.86	23090842
277 (in isoform 8)	Phosphorylation	-	57.86	23090842
278 (in isoform 7)	Phosphorylation	-	53.84	22777824
278 (in isoform 8)	Phosphorylation	-	53.84	22777824
289	Phosphorylation	IVRLQILTPRAGLRL EEEEEEECCCCCEEE	16.62	30266825
289 (in isoform 6)	Phosphorylation	-	16.62	27251275
295	Methylation	LTPRAGLRLVAPDVE ECCCCCEEEEECCCC	26.63	54560825
306	Phosphorylation	PDVEGMRSSPGNKDK CCCCCCCCCCCCCCC	31.80	22617229
307 (in isoform 6)	Phosphorylation	-	26.85	27251275
307	Phosphorylation	DVEGMRSSPGNKDKE CCCCCCCCCCCCCCC	26.85	25849741
341	Phosphorylation	PNTDAARSSAQLSDG CCCHHHHHHCCCCCC	25.87	28348404
342	Phosphorylation	NTDAARSSAQLSDGN CCHHHHHHCCCCCCC	17.93	28348404
350 (in isoform 8)	Phosphorylation	-	8.69	28348404
352	Phosphorylation	LSDGNVGSGATGSRP CCCCCCCCCCCCCCC	22.44	27251275
354 (in isoform 2)	Ubiquitination	-	15.53	21890473
355	Phosphorylation	GNVGSGATGSRPEGL CCCCCCCCCCCCCCE	38.93	27251275
357 (in isoform 6)	Phosphorylation	-	40.06	27251275
357	Phosphorylation	VGSGATGSRPEGLAA CCCCCCCCCCCCEEE	40.06	27251275
359 (in isoform 1)	Ubiquitination	-	41.53	21890473
373	Phosphorylation	DIGSERGSSSATSVS ECCCCCCCCCCCEEE	27.60	27251275
374	Phosphorylation	IGSERGSSSATSVSA CCCCCCCCCCCEEEE	27.15	27251275
375	Phosphorylation	GSERGSSSATSVSAV CCCCCCCCCCEEEEC	36.94	27251275
376 (in isoform 8)	Phosphorylation	-	13.07	23663014
377	Phosphorylation	ERGSSSATSVSAVPA CCCCCCCCEEEECCC	31.44	27251275
377 (in isoform 8)	Phosphorylation	-	31.44	23663014
378	Phosphorylation	RGSSSATSVSAVPAD CCCCCCCEEEECCCC	17.50	27251275
378 (in isoform 8)	Phosphorylation	-	17.50	23663014
379 (in isoform 6)	Phosphorylation	-	3.56	28348404
380 (in isoform 8)	Phosphorylation	-	24.26	23663014
381 (in isoform 8)	Phosphorylation	-	14.79	23663014
383 (in isoform 8)	Phosphorylation	-	28.32	23663014
388	Phosphorylation	AVPADRKSNSTAAQE ECCCCCCCCCHHHHH	36.59	28985074
390	Phosphorylation	PADRKSNSTAAQEDA CCCCCCCCHHHHHHH	26.89	23403867
391	Phosphorylation	ADRKSNSTAAQEDAK CCCCCCCHHHHHHHH	30.20	23403867
405 (in isoform 6)	Phosphorylation	-	5.20	23663014
406 (in isoform 6)	Phosphorylation	-	19.46	23663014
407 (in isoform 6)	Phosphorylation	-	42.75	23663014
408	Phosphorylation	PKGALADYEGKDVAT CCCCCCCCCCCCHHH	22.45	27273156
409 (in isoform 6)	Phosphorylation	-	61.38	23663014
410 (in isoform 6)	Phosphorylation	-	25.82	23663014
412 (in isoform 6)	Phosphorylation	-	46.25	23663014
415	Phosphorylation	YEGKDVATRVGEAWQ CCCCCHHHHHHHHHH	26.24	28442448
440 (in isoform 6)	Phosphorylation	-	43.66	27642862
446	Phosphorylation	AQQPADPSTPERQSS CCCCCCCCCCCCCCC	58.08	29255136
447	Phosphorylation	QQPADPSTPERQSSP CCCCCCCCCCCCCCC	34.26	29255136
452	Phosphorylation	PSTPERQSSPSGSEQ CCCCCCCCCCCCHHH	50.90	29255136
453	Phosphorylation	STPERQSSPSGSEQL CCCCCCCCCCCHHHH	18.10	19664994
455	Phosphorylation	PERQSSPSGSEQLVR CCCCCCCCCHHHHHC	57.82	30266825
457	Phosphorylation	RQSSPSGSEQLVRRE CCCCCCCHHHHHCHH	26.89	30278072
465	Phosphorylation	EQLVRRESCGSSVLT HHHHCHHHCCCCEEE	23.20	29255136
468	Phosphorylation	VRRESCGSSVLTDFE HCHHHCCCCEEECCC	22.92	29255136
469	Phosphorylation	RRESCGSSVLTDFEG CHHHCCCCEEECCCC	13.36	29255136
472	Phosphorylation	SCGSSVLTDFEGKDV HCCCCEEECCCCCCC	36.16	23927012
478 (in isoform 6)	Phosphorylation	-	46.25	27251275
479 (in isoform 6)	Phosphorylation	-	9.20	27251275
481	Phosphorylation	FEGKDVATKVGEAWQ CCCCCCCHHHHHHHH	26.55	23403867
485 (in isoform 6)	Phosphorylation	-	50.12	27251275
489 (in isoform 6)	Phosphorylation	-	48.30	27251275
497 (in isoform 6)	Phosphorylation	-	29.58	27251275
500 (in isoform 6)	Phosphorylation	-	21.79	27251275
505	Phosphorylation	QGDPAVPTQQPADPS CCCCCCCCCCCCCCC	32.98	26657352
512	Phosphorylation	TQQPADPSTPEQQNS CCCCCCCCCHHHCCC	58.08	30266825
513	Phosphorylation	QQPADPSTPEQQNSP CCCCCCCCHHHCCCC	35.91	30266825
519	Phosphorylation	STPEQQNSPSGSEQF CCHHHCCCCCCCHHH	18.99	30266825
521	Phosphorylation	PEQQNSPSGSEQFVR HHHCCCCCCCHHHHH	55.56	30266825
523	Phosphorylation	QQNSPSGSEQFVRRE HCCCCCCCHHHHHHH	32.34	30266825
531	Phosphorylation	EQFVRRESCTSRVRS HHHHHHHHCCCCCCC	22.38	30242111
533	Phosphorylation	FVRRESCTSRVRSPS HHHHHHCCCCCCCCC	28.93	30242111
534	Phosphorylation	VRRESCTSRVRSPSS HHHHHCCCCCCCCCC	32.86	30242111
538	Phosphorylation	SCTSRVRSPSSCMVT HCCCCCCCCCCCEEE	26.69	25849741
540	Phosphorylation	TSRVRSPSSCMVTVT CCCCCCCCCCEEEEE	37.10	25849741
541	Phosphorylation	SRVRSPSSCMVTVTV CCCCCCCCCEEEEEE	15.04	28450419
545 (in isoform 6)	Phosphorylation	-	5.42	27251275
545	Phosphorylation	SPSSCMVTVTVTATS CCCCCEEEEEEEECC	5.42	28450419
547	Phosphorylation	SSCMVTVTVTATSEQ CCCEEEEEEEECCCC	11.63	28450419
549	Phosphorylation	CMVTVTVTATSEQPH CEEEEEEEECCCCCE	18.17	28450419
551 (in isoform 6)	Phosphorylation	-	24.35	27251275
551	Phosphorylation	VTVTVTATSEQPHIY EEEEEEECCCCCEEE	24.35	28450419
552	Phosphorylation	TVTVTATSEQPHIYI EEEEEECCCCCEEEE	31.60	28450419
558	Phosphorylation	TSEQPHIYIPAPASE CCCCCEEEEECCHHH	9.60	23090842
564	Phosphorylation	IYIPAPASELDSSST EEEECCHHHCCCCCC	37.32	23090842
568	Phosphorylation	APASELDSSSTTKGI CCHHHCCCCCCCCEE	38.52	23090842
569	Phosphorylation	PASELDSSSTTKGIL CHHHCCCCCCCCEEE	31.22	23090842
570 (in isoform 6)	Phosphorylation	-	44.01	27251275
570	Phosphorylation	ASELDSSSTTKGILF HHHCCCCCCCCEEEE	44.01	23090842
571	Phosphorylation	SELDSSSTTKGILFV HHCCCCCCCCEEEEE	34.18	23090842
572	Phosphorylation	ELDSSSTTKGILFVK HCCCCCCCCEEEEEE	29.26	23090842
581	Phosphorylation	GILFVKEYVNASEVS EEEEEEEEECHHHHC	8.03	28796482
585	Phosphorylation	VKEYVNASEVSSGKP EEEEECHHHHCCCCC	33.07	27307780
591	Ubiquitination	ASEVSSGKPVSARYS HHHHCCCCCCCCCCC	44.16	-
591	Ubiquitination	ASEVSSGKPVSARYS HHHHCCCCCCCCCCC	44.16	21890473
591	Ubiquitination	ASEVSSGKPVSARYS HHHHCCCCCCCCCCC	44.16	21890473
591	Ubiquitination	ASEVSSGKPVSARYS HHHHCCCCCCCCCCC	44.16	21890473
591	Ubiquitination	ASEVSSGKPVSARYS HHHHCCCCCCCCCCC	44.16	21890473
591	Acetylation	ASEVSSGKPVSARYS HHHHCCCCCCCCCCC	44.16	26051181
592	Ubiquitination	SEVSSGKPVSARYSN HHHCCCCCCCCCCCC	28.90	21890473
594	Phosphorylation	VSSGKPVSARYSNVS HCCCCCCCCCCCCCC	18.63	27307780
594	Ubiquitination	VSSGKPVSARYSNVS HCCCCCCCCCCCCCC	18.63	21890473
597	Phosphorylation	GKPVSARYSNVSSIE CCCCCCCCCCCCCHH	12.33	28442448
598	Phosphorylation	KPVSARYSNVSSIED CCCCCCCCCCCCHHH	25.79	28442448
601	Phosphorylation	SARYSNVSSIEDSFA CCCCCCCCCHHHHHC	29.83	29523821
602	Phosphorylation	ARYSNVSSIEDSFAM CCCCCCCCHHHHHCC	26.22	28355574
606	Phosphorylation	NVSSIEDSFAMEKKP CCCCHHHHHCCCCCC	11.34	29523821
613 (in isoform 6)	Phosphorylation	-	40.25	27642862
618	Phosphorylation	KKPPCGSTPYSERTT CCCCCCCCCCCCCCC	16.13	24719451
623	Ubiquitination	GSTPYSERTTGGICT CCCCCCCCCCCCCCH	31.48	21890473
626 (in isoform 6)	Phosphorylation	-	23.90	27642862
629 (in isoform 6)	Phosphorylation	-	2.22	27642862
630	Phosphorylation	RTTGGICTYCNREIR CCCCCCCHHCCCCCC	29.23	28152594
631	Phosphorylation	TTGGICTYCNREIRD CCCCCCHHCCCCCCC	5.36	28152594
633 (in isoform 6)	Phosphorylation	-	33.92	27251275
634 (in isoform 6)	Phosphorylation	-	36.84	27251275
654	Phosphorylation	LGICCHEYCFKCGIC HCCCHHHHHHHCCCC	4.59	28152594
663 (in isoform 6)	Phosphorylation	-	34.31	27642862

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN185_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN185_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN185_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ZN185_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-513 AND SER-519, ANDMASS SPECTROMETRY.
PubMed: 19413330

"Phosphoproteome of resting human platelets.";
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.;
J. Proteome Res. 7:526-534(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-447 AND SER-453, ANDMASS SPECTROMETRY.
PubMed: 18088087