TMM40_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMM40_HUMAN
• UniProt AC: Q8WWA1
• Protein Name: Transmembrane protein 40
• Gene Name: TMEM40
• Organism: Homo sapiens (Human).
• Sequence Length: 233
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Sequence: METSASSSQPQDNSQVHRETEDVDYGETDFHKQDGKAGLFSQEQYERNKSSSSSSSSSSSSSSSSSSSSSESNDEDQQPRATGKHRRSLGAGYPHGNGSPGPGHGEPDVLKDELQLYGDAPGEVVPSGESGLRRRGSDPASGEVEASQLRRLNIKKDDEFFHFVLLCFAIGALLVCYHYYADWFMSLGVGLLTFASLETVGIYFGLVYRIHSVLQGFIPLFQKFRLTGFRKTD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Sulfoxidation	-------METSASSS -------CCCCCCCC	13.15	28465586
1	Acetylation	-------METSASSS -------CCCCCCCC	13.15	12665801
3	Phosphorylation	-----METSASSSQP -----CCCCCCCCCC	28.44	24043423
4	Phosphorylation	----METSASSSQPQ ----CCCCCCCCCCC	16.91	24043423
6	Phosphorylation	--METSASSSQPQDN --CCCCCCCCCCCCC	30.23	24043423
7	Phosphorylation	-METSASSSQPQDNS -CCCCCCCCCCCCCC	32.48	24043423
8	Phosphorylation	METSASSSQPQDNSQ CCCCCCCCCCCCCCC	43.30	24043423
14	Phosphorylation	SSQPQDNSQVHRETE CCCCCCCCCCCCHHH	41.70	24043423
41	Phosphorylation	DGKAGLFSQEQYERN CCCCCCCCHHHHHHH	37.54	29888752
45	Phosphorylation	GLFSQEQYERNKSSS CCCCHHHHHHHCCCC	18.99	28674151
51	Phosphorylation	QYERNKSSSSSSSSS HHHHHCCCCCCCCCC	35.53	-
52	Phosphorylation	YERNKSSSSSSSSSS HHHHCCCCCCCCCCC	41.13	-
53	Phosphorylation	ERNKSSSSSSSSSSS HHHCCCCCCCCCCCC	35.87	-
54	Phosphorylation	RNKSSSSSSSSSSSS HHCCCCCCCCCCCCC	35.87	-
55	Phosphorylation	NKSSSSSSSSSSSSS HCCCCCCCCCCCCCC	35.87	-
56	Phosphorylation	KSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
57	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
58	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
59	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
60	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	19664994
61	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
62	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
63	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
64	Phosphorylation	SSSSSSSSSSSSSSE CCCCCCCCCCCCCCC	35.87	-
65	Phosphorylation	SSSSSSSSSSSSSES CCCCCCCCCCCCCCC	35.87	-
67	Phosphorylation	SSSSSSSSSSSESND CCCCCCCCCCCCCCC	35.87	-
68	Phosphorylation	SSSSSSSSSSESNDE CCCCCCCCCCCCCCC	39.57	-
70	Phosphorylation	SSSSSSSSESNDEDQ CCCCCCCCCCCCCCC	47.17	-
82	Phosphorylation	EDQQPRATGKHRRSL CCCCCCCCCCCCHHC	48.30	-
88	Phosphorylation	ATGKHRRSLGAGYPH CCCCCCHHCCCCCCC	30.98	23090842
93	Phosphorylation	RRSLGAGYPHGNGSP CHHCCCCCCCCCCCC	7.48	28270605
99	Phosphorylation	GYPHGNGSPGPGHGE CCCCCCCCCCCCCCC	30.59	28270605
137	Phosphorylation	SGLRRRGSDPASGEV HCCCCCCCCCCCCCC	38.31	23927012
141	Phosphorylation	RRGSDPASGEVEASQ CCCCCCCCCCCCHHH	40.66	30278072
147	Phosphorylation	ASGEVEASQLRRLNI CCCCCCHHHHHHCCC	19.08	23927012
212	Phosphorylation	GLVYRIHSVLQGFIP HHHHHHHHHHHHHHH	23.35	22817900
227	Phosphorylation	LFQKFRLTGFRKTD- HHHHHCCCCCCCCC-	29.98	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMM40_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMM40_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMM40_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TMM40_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Exploring proteomes and analyzing protein processing by massspectrometric identification of sorted N-terminal peptides.";
Gevaert K., Goethals M., Martens L., Van Damme J., Staes A.,Thomas G.R., Vandekerckhove J.;
Nat. Biotechnol. 21:566-569(2003).
Cited for: PROTEIN SEQUENCE OF 1-18, AND ACETYLATION AT MET-1.
PubMed: 12665801

Phosphorylation

"Phosphorylation analysis of primary human T lymphocytes usingsequential IMAC and titanium oxide enrichment.";
Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.;
J. Proteome Res. 7:5167-5176(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137, AND MASSSPECTROMETRY.
PubMed: 19367720