AL1A3_HUMAN - dbPTM
AL1A3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AL1A3_HUMAN
UniProt AC P47895
Protein Name Aldehyde dehydrogenase family 1 member A3
Gene Name ALDH1A3
Organism Homo sapiens (Human).
Sequence Length 512
Subcellular Localization Cytoplasm .
Protein Description NAD-dependent aldehyde dehydrogenase that catalyzes the formation of retinoic acid. [PubMed: 27759097 Has high activity with all-trans retinal, and has much lower in vitro activity with acetaldehyde]
Protein Sequence MATANGAVENGQPDRKPPALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIKLGDKNP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MATANGAVE
------CCCCCCCCC		18.5422814378
30UbiquitinationPIRNLEVKFTKIFIN
CCCCEEEEEEEEEEC		37.63-
33UbiquitinationNLEVKFTKIFINNEW
CEEEEEEEEEECCCE		38.4621906983
44UbiquitinationNNEWHESKSGKKFAT
CCCEEECCCCCCCEE		61.31-
56PhosphorylationFATCNPSTREQICEV
CEECCCCHHHHHEEC		39.2157475007
150UbiquitinationYFAGWADKIQGKTIP
HHHHHHHHCCCEECC		29.2221906983
154UbiquitinationWADKIQGKTIPTDDN
HHHHCCCEECCCCCC		27.23-
218PhosphorylationLTALYLGSLIKEAGF
HHHHHHHHHHHHHCC		25.0724719451
245PhosphorylationPTVGAAISSHPQINK
CCHHHHHHCCCCCCE		20.1922210691
246PhosphorylationTVGAAISSHPQINKI
CHHHHHHCCCCCCEE		32.8322210691
252UbiquitinationSSHPQINKIAFTGST
HCCCCCCEEEEECCH		36.7221906983
263UbiquitinationTGSTEVGKLVKEAAS
ECCHHHHHHHHHHHH		56.1121906983
266UbiquitinationTEVGKLVKEAASRSN
HHHHHHHHHHHHCCC		52.6621906983
278PhosphorylationRSNLKRVTLELGGKN
CCCCCEEEEECCCCC		20.6720166139
284AcetylationVTLELGGKNPCIVCA
EEEECCCCCCEEEEE		56.7926051181
327PhosphorylationVFVEEQVYSEFVRRS
EEEEHHHHHHHHHHH		11.3727642862
328PhosphorylationFVEEQVYSEFVRRSV
EEEHHHHHHHHHHHH		26.21110745241
339SuccinylationRRSVEYAKKRPVGDP
HHHHHHHHCCCCCCC		48.7023954790
340UbiquitinationRSVEYAKKRPVGDPF
HHHHHHHCCCCCCCC		54.4821906983
350UbiquitinationVGDPFDVKTEQGPQI
CCCCCCCCCCCCCCC		48.4621906983
360UbiquitinationQGPQIDQKQFDKILE
CCCCCCHHHHHHHHH		49.5421906983
364UbiquitinationIDQKQFDKILELIES
CCHHHHHHHHHHHHH		50.94-
373SuccinylationLELIESGKKEGAKLE
HHHHHHCCCCCCEEC		57.8623954790
373UbiquitinationLELIESGKKEGAKLE
HHHHHHCCCCCCEEC		57.86-
394UbiquitinationEDKGLFIKPTVFSEV
CCCCCEECCEEEECC		27.5721906983
409UbiquitinationTDNMRIAKEEIFGPV
CCCCHHHHHHHHCCC		54.2121906983
421UbiquitinationGPVQPILKFKSIEEV
CCCHHHEECCCHHHH		52.0121906983
423UbiquitinationVQPILKFKSIEEVIK
CHHHEECCCHHHHHH		49.2721906983
424PhosphorylationQPILKFKSIEEVIKR
HHHEECCCHHHHHHH		38.0619664994
430UbiquitinationKSIEEVIKRANSTDY
CCHHHHHHHCCCCCC		51.1121906983
434PhosphorylationEVIKRANSTDYGLTA
HHHHHCCCCCCCCCH		22.9828152594
435PhosphorylationVIKRANSTDYGLTAA
HHHHCCCCCCCCCHH		32.8028152594
437PhosphorylationKRANSTDYGLTAAVF
HHCCCCCCCCCHHHC		17.7019664995
440PhosphorylationNSTDYGLTAAVFTKN
CCCCCCCCHHHCCCC		14.2828152594
446UbiquitinationLTAAVFTKNLDKALK
CCHHHCCCCHHHHHH		44.0121906983
483PhosphorylationPFGGFKMSGNGRELG
CCCCEEECCCCCCHH		29.6920068231
492PhosphorylationNGRELGEYALAEYTE
CCCCHHHHHHEECEE		12.7128152594
497PhosphorylationGEYALAEYTEVKTVT
HHHHHEECEEEEEEE		11.5528152594
498PhosphorylationEYALAEYTEVKTVTI
HHHHEECEEEEEEEE		26.30110745247
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AL1A3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AL1A3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AL1A3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of AL1A3_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
615113Microphthalmia, isolated, 8 (MCOP8)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00162Vitamin A
Regulatory Network of AL1A3_HUMAN

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Related Literatures of Post-Translational Modification

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