MYBB_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYBB_MOUSE
• UniProt AC: P48972
• Protein Name: Myb-related protein B
• Gene Name: Mybl2
• Organism: Mus musculus (Mouse).
• Sequence Length: 704
• Subcellular Localization: Nucleus.
• Protein Description: Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene (By similarity)..
• Protein Sequence: MSRRTRCEDLDELHYQDVDSDLLEQRDNRCKVKWTHEEDEQLRALVRQFGQQDWKFLASHFPNRTDQQCQYRWLRVLNPDLVKGPWTKEEDQKVIELVKKYGTKQWTLIAKHLKGRLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWAEIAKMLPGRTDNAVKNHWNSTIKRKVDTGGFPAESRDCKPVYLLLELEDKEQHQGVQPVDGQGSLVSSWPLVPSIVKEESSEEEIAIAATSAKELGHEPVPADLGEVRTPEPPESLKREYQEFSSPETSLPYKWVVEAANLLIPAVGSSLSEALDLIESDPDAWCDLSKFDLPEEPSTEGSVVSSPVQPQTSQQQQEEALQSSQQAATPGPSVTEYRLDGHTISDLSRSSRGELIPISPSTEFGGSGIGTPPSVLKRQKKRRVALSPVTENSASLSFLDSCNSLTPKSTPVKTLPFSPSQFLNFWNKQDTLELESPSLTSTPVCSQKVVVTTPLHRDKTPLHQKYPSSEVLPDQKYSMDNTPHTPTPFKNALEKYGPLKPLPQTPHLEEDLKEVLRSEAGMELIIEDDMRPEKQKRKPGLRRSPIKKVRKSLALDIMDEDGKLMSSTMPKPLSLPTSVTPSSCGFTSPGSKEGNSLLNQGFLQAKPEKVVAAQKTRSHIPTPAPMTHAWKTVACGGTKDQLFMQEKARQLLSRLKSSHTSRTLILS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
168	Phosphorylation	AKMLPGRTDNAVKNH HHHCCCCCCHHHHHH	39.25	22817900
178	Phosphorylation	AVKNHWNSTIKRKVD HHHHHHHHHHHCCCC	26.73	24759943
179	Phosphorylation	VKNHWNSTIKRKVDT HHHHHHHHHHCCCCC	27.57	24759943
183	Acetylation	WNSTIKRKVDTGGFP HHHHHHCCCCCCCCC	39.19	7609875
197	Acetylation	PAESRDCKPVYLLLE CCCCCCCCEEEEEEE	41.63	7609887
238	Phosphorylation	PSIVKEESSEEEIAI CCEECCCCCHHHHHH	44.11	21149613
239	Phosphorylation	SIVKEESSEEEIAIA CEECCCCCHHHHHHH	52.92	21149613
267	Phosphorylation	ADLGEVRTPEPPESL CCCCCCCCCCCCHHH	36.86	25266776
273	Phosphorylation	RTPEPPESLKREYQE CCCCCCHHHHHHHHH	44.99	28066266
278	Phosphorylation	PESLKREYQEFSSPE CHHHHHHHHHHCCCC	19.85	25159016
282	Phosphorylation	KREYQEFSSPETSLP HHHHHHHCCCCCCCC	44.20	21082442
283	Phosphorylation	REYQEFSSPETSLPY HHHHHHCCCCCCCCH	31.88	21082442
286	Phosphorylation	QEFSSPETSLPYKWV HHHCCCCCCCCHHHH	38.66	25159016
287	Phosphorylation	EFSSPETSLPYKWVV HHCCCCCCCCHHHHH	26.19	25159016
387	Phosphorylation	TISDLSRSSRGELIP CHHHCCCCCCCCEEE	22.47	23984901
388	Phosphorylation	ISDLSRSSRGELIPI HHHCCCCCCCCEEEC	43.10	23984901
396	Phosphorylation	RGELIPISPSTEFGG CCCEEECCCCCCCCC	13.88	25266776
398	Phosphorylation	ELIPISPSTEFGGSG CEEECCCCCCCCCCC	33.50	26745281
399	Phosphorylation	LIPISPSTEFGGSGI EEECCCCCCCCCCCC	38.42	26745281
404	Phosphorylation	PSTEFGGSGIGTPPS CCCCCCCCCCCCCHH	27.84	25266776
408	Phosphorylation	FGGSGIGTPPSVLKR CCCCCCCCCHHHHHH	30.06	26745281
411	Phosphorylation	SGIGTPPSVLKRQKK CCCCCCHHHHHHHHC	41.08	25777480
424	Phosphorylation	KKRRVALSPVTENSA HCCCEEECCCCCCCC	13.95	25266776
427	Phosphorylation	RVALSPVTENSASLS CEEECCCCCCCCCCH	32.60	26745281
430	Phosphorylation	LSPVTENSASLSFLD ECCCCCCCCCCHHHH	17.01	26643407
432	Phosphorylation	PVTENSASLSFLDSC CCCCCCCCCHHHHHC	25.11	26643407
434	Phosphorylation	TENSASLSFLDSCNS CCCCCCCHHHHHCCC	22.67	26643407
438	Phosphorylation	ASLSFLDSCNSLTPK CCCHHHHHCCCCCCC	19.83	26643407
441	Phosphorylation	SFLDSCNSLTPKSTP HHHHHCCCCCCCCCC	37.64	26643407
443	Phosphorylation	LDSCNSLTPKSTPVK HHHCCCCCCCCCCCC	28.61	10095772
446	Phosphorylation	CNSLTPKSTPVKTLP CCCCCCCCCCCCCCC	38.86	25266776
447	Phosphorylation	NSLTPKSTPVKTLPF CCCCCCCCCCCCCCC	37.92	11264176
450	Ubiquitination	TPKSTPVKTLPFSPS CCCCCCCCCCCCCHH	45.61	-
455	Phosphorylation	PVKTLPFSPSQFLNF CCCCCCCCHHHHHHH	23.00	26745281
457	Phosphorylation	KTLPFSPSQFLNFWN CCCCCCHHHHHHHHC	32.16	23984901
475	Phosphorylation	TLELESPSLTSTPVC CEEECCCCCCCCCCC	54.26	21082442
478	Phosphorylation	LESPSLTSTPVCSQK ECCCCCCCCCCCCCE	35.69	21082442
489	Phosphorylation	CSQKVVVTTPLHRDK CCCEEEEECCCCCCC	15.87	28066266
490	Phosphorylation	SQKVVVTTPLHRDKT CCEEEEECCCCCCCC	16.55	11264176
497	Phosphorylation	TPLHRDKTPLHQKYP CCCCCCCCCCHHCCC	35.06	11264176
505	Phosphorylation	PLHQKYPSSEVLPDQ CCHHCCCCCCCCCCC	35.72	27841257
514	Phosphorylation	EVLPDQKYSMDNTPH CCCCCCCCCCCCCCC	12.00	28978645
515	Phosphorylation	VLPDQKYSMDNTPHT CCCCCCCCCCCCCCC	27.05	28978645
519	Phosphorylation	QKYSMDNTPHTPTPF CCCCCCCCCCCCCCC	16.51	26643407
522	Phosphorylation	SMDNTPHTPTPFKNA CCCCCCCCCCCCHHH	30.02	25266776
524	Phosphorylation	DNTPHTPTPFKNALE CCCCCCCCCCHHHHH	42.38	10095772
542	Phosphorylation	PLKPLPQTPHLEEDL CCCCCCCCCCHHHHH	15.67	25266776
581	Phosphorylation	RKPGLRRSPIKKVRK CCCCCCCCHHHHHHH	25.25	11264176
589	Phosphorylation	PIKKVRKSLALDIMD HHHHHHHHHHHEEEC	14.33	25266776
615	Phosphorylation	KPLSLPTSVTPSSCG CCCCCCCCCCCHHCC	23.27	26643407
617	Phosphorylation	LSLPTSVTPSSCGFT CCCCCCCCCHHCCCC	19.74	26643407
619	Phosphorylation	LPTSVTPSSCGFTSP CCCCCCCHHCCCCCC	28.97	26643407
620	Phosphorylation	PTSVTPSSCGFTSPG CCCCCCHHCCCCCCC	21.33	26643407
624	Phosphorylation	TPSSCGFTSPGSKEG CCHHCCCCCCCCHHH	21.21	26643407
625	Phosphorylation	PSSCGFTSPGSKEGN CHHCCCCCCCCHHHC	25.63	26643407
628	Phosphorylation	CGFTSPGSKEGNSLL CCCCCCCCHHHCCHH	30.80	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
267	T	Phosphorylation	Kinase	CDK2	P97377	PSP
283	S	Phosphorylation	Kinase	CDK2	P97377	PSP
396	S	Phosphorylation	Kinase	CDK2	P97377	PSP
408	T	Phosphorylation	Kinase	CDK2	P97377	PSP
443	T	Phosphorylation	Kinase	CDK2	P97377	Uniprot
447	T	Phosphorylation	Kinase	CDK2	P24941	PSP
447	T	Phosphorylation	Kinase	CDK2	P97377	Uniprot
455	S	Phosphorylation	Kinase	CDK2	P97377	PSP
490	T	Phosphorylation	Kinase	CDK2	P24941	PSP
490	T	Phosphorylation	Kinase	CDK2	P97377	Uniprot
497	T	Phosphorylation	Kinase	CDK2	P24941	PSP
497	T	Phosphorylation	Kinase	CDK2	P97377	Uniprot
519	T	Phosphorylation	Kinase	CDK2	P97377	PSP
522	T	Phosphorylation	Kinase	CDK2	P97377	PSP
524	T	Phosphorylation	Kinase	CDK2	P97377	Uniprot
581	S	Phosphorylation	Kinase	CDK2	P97377	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
524	T	Phosphorylation	Phosphorylation at Thr-524 is probably involved in transcriptional activity (By similarity).	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYBB_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CCND1_HUMAN	CCND1	physical	10645009
IKZF2_MOUSE	Ikzf2	physical	20211142
GCFC2_MOUSE	Gcfc2	physical	20211142

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.