IKZF2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IKZF2_MOUSE
• UniProt AC: P81183
• Protein Name: Zinc finger protein Helios
• Gene Name: Ikzf2
• Organism: Mus musculus (Mouse).
• Sequence Length: 526
• Subcellular Localization: Nucleus.
• Protein Description: Associates with Ikaros at centromeric heterochromatin..
• Protein Sequence: METDAIDGYITCDNELSPEGEHANMAIDLTSSTPNGQHASPSHMTSTNSVKLEMQSDEECDRQPLSREDEIRGHDEGSSLEEPLIESSEVADNRKVQDLQGEGGIRLPNGKLKCDVCGMVCIGPNVLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCSYACRRRDALTGHLRTHSVGKPHKCNYCGRSYKQRSSLEEHKERCHNYLQNVSMEAAGQVMSHHVPPMEDCKEQEPIMDNNISLVPFERPAVIEKLTANMGKRKSSTPQKFVGEKLMRFSYPDIHFDMNLTYEKEAELMQSHMMDQAINNAITYLGAEALHPLMQHAPSTIAEVAPVISSAYSQVYHPNRIERPISRETSDSHENNMDGPISLIRPKSRPQEREASPSNSCLDSTDSESSHDDRQSYQGNPALNPKRKQSPAYMKEDVKALDATKAPKGSLKDIYKVFNGEGEQIRAFKCEHCRVLFLDHVMYTIHMGCHGYRDPLECNICGYRSQDRYEFSSHIVRGEHTFH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
56	Phosphorylation	SVKLEMQSDEECDRQ CCEEEECCCCHHHCC	45.75	26824392
66	Phosphorylation	ECDRQPLSREDEIRG HHHCCCCCHHHHHCC	40.06	28833060
78	Phosphorylation	IRGHDEGSSLEEPLI HCCCCCCCCCCCCCC	29.69	28833060
79	Phosphorylation	RGHDEGSSLEEPLIE CCCCCCCCCCCCCCC	51.13	28833060
87	Phosphorylation	LEEPLIESSEVADNR CCCCCCCCCHHCCCC	25.46	22345495
88	Phosphorylation	EEPLIESSEVADNRK CCCCCCCCHHCCCCC	24.25	22345495
163	Phosphorylation	LRHIKLHSGEKPFKC CEEEEECCCCCCCCC	60.11	25266776
191	Phosphorylation	TGHLRTHSVGKPHKC HCCCCCCCCCCCCCC	31.77	25266776
209	Phosphorylation	GRSYKQRSSLEEHKE CCCHHHCCCHHHHHH	36.46	-
210	Phosphorylation	RSYKQRSSLEEHKER CCHHHCCCHHHHHHH	41.82	-
278	Phosphorylation	ANMGKRKSSTPQKFV HHCCCCCCCCCCHHH	43.40	20139300
279	Phosphorylation	NMGKRKSSTPQKFVG HCCCCCCCCCCHHHH	47.33	26745281
280	Phosphorylation	MGKRKSSTPQKFVGE CCCCCCCCCCHHHHH	36.51	30482847
288	Acetylation	PQKFVGEKLMRFSYP CCHHHHHHHHHCCCC	41.47	22902405
293	Phosphorylation	GEKLMRFSYPDIHFD HHHHHHCCCCCEEEE	25.95	27600695
304	Phosphorylation	IHFDMNLTYEKEAEL EEEECCCCHHHHHHH	25.32	26745281
369	Phosphorylation	NRIERPISRETSDSH CCCCCCCCCCCCCCC	27.09	22817900
372	Phosphorylation	ERPISRETSDSHENN CCCCCCCCCCCCCCC	36.40	28833060
373	Phosphorylation	RPISRETSDSHENNM CCCCCCCCCCCCCCC	32.15	28833060
375	Phosphorylation	ISRETSDSHENNMDG CCCCCCCCCCCCCCC	32.25	28833060
399	Phosphorylation	RPQEREASPSNSCLD CCCCCCCCCCCCCCC	24.90	28973931
433	Phosphorylation	LNPKRKQSPAYMKED CCCCCCCCCCHHHHH	17.96	25266776
487	Phosphorylation	FLDHVMYTIHMGCHG EECCHHHHHCCCCCC	6.06	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IKZF2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IKZF2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IKZF2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of IKZF2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.