FILA2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FILA2_HUMAN
• UniProt AC: Q5D862
• Protein Name: Filaggrin-2
• Gene Name: FLG2
• Organism: Homo sapiens (Human).
• Sequence Length: 2391
• Subcellular Localization: Cytoplasm . Cytoplasmic granule . In the stratum corneum of the epidermis, dispersed diffusely throughout the cytoplasm, while in the stratum granulosum, localized within keratohyalin granules (PubMed:19384417) (PubMed:21531719). In granular keratino
• Protein Sequence: MTDLLRSVVTVIDVFYKYTKQDGECGTLSKGELKELLEKELHPVLKNPDDPDTVDVIMHMLDRDHDRRLDFTEFLLMIFKLTMACNKVLSKEYCKASGSKKHRRGHRHQEEESETEEDEEDTPGHKSGYRHSSWSEGEEHGYSSGHSRGTVKCRHGSNSRRLGRQGNLSSSGNQEGSQKRYHRSSCGHSWSGGKDRHGSSSVELRERINKSHISPSRESGEEYESGSGSNSWERKGHGGLSCGLETSGHESNSTQSRIREQKLGSSCSGSGDSGRRSHACGYSNSSGCGRPQNASSSCQSHRFGGQGNQFSYIQSGCQSGIKGGQGHGCVSGGQPSGCGQPESNPCSQSYSQRGYGARENGQPQNCGGQWRTGSSQSSCCGQYGSGGSQSCSNGQHEYGSCGRFSNSSSSNEFSKCDQYGSGSSQSTSFEQHGTGLSQSSGFEQHVCGSGQTCGQHESTSSQSLGYDQHGSSSGKTSGFGQHGSGSGQSSGFGQCGSGSGQSSGFGQHGSVSGQSSGFGQHGSVSGQSSGFGQHESRSRQSSYGQHGSGSSQSSGYGQYGSRETSGFGQHGLGSGQSTGFGQYGSGSGQSSGFGQHGSGSGQSSGFGQHESRSGQSSYGQHSSGSSQSSGYGQHGSRQTSGFGQHGSGSSQSTGFGQYGSGSGQSSGFGQHVSGSGQSSGFGQHESRSGHSSYGQHGFGSSQSSGYGQHGSSSGQTSGFGQHELSSGQSSSFGQHGSGSGQSSGFGQHGSGSGQSSGFGQHESRSGQSSYGQHSSGSSQSSGYGQHGSRQTSGFGQHGSGSSQSTGFGQYGSGSGQSAGFGQHGSGSGQSSGFGQHESRSHQSSYGQHGSGSSQSSGYGQHGSSSGQTSGFGQHRSSSGQYSGFGQHGSGSGQSSGFGQHGTGSGQYSGFGQHESRSHQSSYGQHGSGSSQSSGYGQHGSSSGQTFGFGQHRSGSGQSSGFGQHGSGSGQSSGFGQHESGSGKSSGFGQHESRSSQSNYGQHGSGSSQSSGYGQHGSSSGQTTGFGQHRSSSGQYSGFGQHGSGSDQSSGFGQHGTGSGQSSGFGQYESRSRQSSYGQHGSGSSQSSGYGQHGSNSGQTSGFGQHRPGSGQSSGFGQYGSGSGQSSGFGQHGSGTGKSSGFAQHEYRSGQSSYGQHGTGSSQSSGCGQHESGSGPTTSFGQHVSGSDNFSSSGQHISDSGQSTGFGQYGSGSGQSTGLGQGESQQVESGSTVHGRQETTHGQTINTTRHSQSGQGQSTQTGSRVTRRRRSSQSENSDSEVHSKVSHRHSEHIHTQAGSHYPKSGSTVRRRQGTTHGQRGDTTRHGHSGHGQSTQTGSRTSGRQRFSHSDATDSEVHSGVSHRPHSQEQTHSQAGSQHGESESTVHERHETTYGQTGEATGHGHSGHGQSTQRGSRTTGRRGSGHSESSDSEVHSGGSHRPQSQEQTHGQAGSQHGESGSTVHGRHGTTHGQTGDTTRHAHYHHGKSTQRGSSTTGRRGSGHSESSDSEVHSGGSHTHSGHTHGQSGSQHGESESIIHDRHRITHGQTGDTTRHSYSGHEQTTQTGSRTTGRQRTSHSESTDSEVHSGGSHRPHSREHTYGQAGSQHEEPEFTVHERHGTTHGQIGDTTGHSHSGHGQSTQRGSRTTGRQRSSHSESSDSEVHSGVSHTHTGHTHGQAGSQHGQSESIVPERHGTTHGQTGDTTRHAHYHHGLTTQTGSRTTGRRGSGHSEYSDSEGYSGVSHTHSGHTHGQARSQHGESESIVHERHGTIHGQTGDTTRHAHSGHGQSTQTGSRTTGRRSSGHSEYSDSEGHSGFSQRPHSRGHTHGQAGSQHGESESIVDERHGTTHGQTGDTSGHSQSGHGQSTQSGSSTTGRRRSGHSESSDSEVHSGGSHTHSGHTHSQARSQHGESESTVHKRHQTTHGQTGDTTEHGHPSHGQTIQTGSRTTGRRGSGHSEYSDSEGPSGVSHTHSGHTHGQAGSHYPESGSSVHERHGTTHGQTADTTRHGHSGHGQSTQRGSRTTGRRASGHSEYSDSEGHSGVSHTHSGHAHGQAGSQHGESGSSVHERHGTTHGQTGDTTRHAHSGHGQSTQRGSRTAGRRGSGHSESSDSEVHSGVSHTHSGHTYGQARSQHGESGSAIHGRQGTIHGQTGDTTRHGQSGHGQSTQTGSRTTGRQRSSHSESSDSEVHSEASPTHSGHTHSQAGSRHGQSGSSGHGRQGTTHGQTGDTTRHAHYGYGQSTQRGSRTTGRRGSGHSESSDSEVHSWGSHTHSGHIQGQAGSQQRQPGSTVHGRLETTHGQTGDTTRHGHSGYGQSTQTGSRSSRASHFQSHSSERQRHGSSQVWKHGSYGPAEYDYGHTGYGPSGGSRKSISNSHLSWSTDSTANKQLSRH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	VIDVFYKYTKQDGEC HHHHHHHHHCCCCCC	14.06	29083192
19	Phosphorylation	IDVFYKYTKQDGECG HHHHHHHHCCCCCCC	20.34	29083192
27	Phosphorylation	KQDGECGTLSKGELK CCCCCCCCCCHHHHH	39.25	29083192
29	Phosphorylation	DGECGTLSKGELKEL CCCCCCCCHHHHHHH	38.15	29083192
113	Phosphorylation	HRHQEEESETEEDEE CCCCHHHCCCCCCCC	53.77	21082442
115	Phosphorylation	HQEEESETEEDEEDT CCHHHCCCCCCCCCC	54.69	21082442
122	Phosphorylation	TEEDEEDTPGHKSGY CCCCCCCCCCCCCCC	34.15	-
127	Phosphorylation	EDTPGHKSGYRHSSW CCCCCCCCCCCCCCC	35.07	-
129	Phosphorylation	TPGHKSGYRHSSWSE CCCCCCCCCCCCCCC	16.55	-
169	Phosphorylation	LGRQGNLSSSGNQEG CCCCCCCCCCCCCCC	26.85	21082442
170	Phosphorylation	GRQGNLSSSGNQEGS CCCCCCCCCCCCCCC	45.49	20068231
171	Phosphorylation	RQGNLSSSGNQEGSQ CCCCCCCCCCCCCCC	38.09	20068231
177	Phosphorylation	SSGNQEGSQKRYHRS CCCCCCCCCCEEEEC	31.60	20068231
225	Phosphorylation	ESGEEYESGSGSNSW CCCCCCCCCCCCCCC	37.04	-
241	Phosphorylation	RKGHGGLSCGLETSG ECCCCCCCCCCCCCC	14.93	-
246	Phosphorylation	GLSCGLETSGHESNS CCCCCCCCCCCCCCC	45.08	-
247	Phosphorylation	LSCGLETSGHESNST CCCCCCCCCCCCCCH	28.86	-
265	Phosphorylation	IREQKLGSSCSGSGD HHHHHCCCCCCCCCC	38.31	20068231
266	Phosphorylation	REQKLGSSCSGSGDS HHHHCCCCCCCCCCC	15.54	20068231
268	Phosphorylation	QKLGSSCSGSGDSGR HHCCCCCCCCCCCCC	37.63	20068231
270	Phosphorylation	LGSSCSGSGDSGRRS CCCCCCCCCCCCCCC	24.12	20068231
273	Phosphorylation	SCSGSGDSGRRSHAC CCCCCCCCCCCCCCC	37.41	20068231
405	Phosphorylation	YGSCGRFSNSSSSNE CCCCCCCCCCCCCCC	34.15	21406692
407	Phosphorylation	SCGRFSNSSSSNEFS CCCCCCCCCCCCCCC	30.33	21406692
408	Phosphorylation	CGRFSNSSSSNEFSK CCCCCCCCCCCCCCC	41.87	21406692
409	Phosphorylation	GRFSNSSSSNEFSKC CCCCCCCCCCCCCCC	36.68	21406692
410	Phosphorylation	RFSNSSSSNEFSKCD CCCCCCCCCCCCCCC	42.18	21406692
414	Phosphorylation	SSSSNEFSKCDQYGS CCCCCCCCCCCCCCC	26.62	21406692
528	Phosphorylation	HGSVSGQSSGFGQHE CCCCCCCCCCCCCCC	35.63	20068231
536	Phosphorylation	SGFGQHESRSRQSSY CCCCCCCCCCCCCCC	33.17	20068231
541	Phosphorylation	HESRSRQSSYGQHGS CCCCCCCCCCCCCCC	25.15	22210691
561	Phosphorylation	SGYGQYGSRETSGFG CCCCCCCCCCCCCCC	23.24	22210691
603	Phosphorylation	HGSGSGQSSGFGQHE CCCCCCCCCCCCCCC	35.63	20068231
611	Phosphorylation	SGFGQHESRSGQSSY CCCCCCCCCCCCCCC	29.62	20068231
678	Phosphorylation	HVSGSGQSSGFGQHE CCCCCCCCCCCCCCC	35.63	20068231
686	Phosphorylation	SGFGQHESRSGHSSY CCCCCCCCCCCCCCC	29.62	20068231
706	Phosphorylation	GSSQSSGYGQHGSSS CCCCCCCCCCCCCCC	18.63	-
755	Phosphorylation	HGSGSGQSSGFGQHE CCCCCCCCCCCCCCC	35.63	20068231
763	Phosphorylation	SGFGQHESRSGQSSY CCCCCCCCCCCCCCC	29.62	20068231
830	Phosphorylation	HGSGSGQSSGFGQHE CCCCCCCCCCCCCCC	35.63	20068231
838	Phosphorylation	SGFGQHESRSHQSSY CCCCCCCCCCCCCCC	36.64	20068231
858	Phosphorylation	GSSQSSGYGQHGSSS CCCCCCCCCCCCCCC	18.63	-
935	Phosphorylation	GSSQSSGYGQHGSSS CCCCCCCCCCCCCCC	18.63	-
953	Phosphorylation	FGFGQHRSGSGQSSG EECCCCCCCCCCCCC	34.88	-
955	Phosphorylation	FGQHRSGSGQSSGFG CCCCCCCCCCCCCCC	34.60	-
984	Phosphorylation	HESGSGKSSGFGQHE CCCCCCCCCCCCCCC	38.94	20068231
992	Phosphorylation	SGFGQHESRSSQSNY CCCCCCCCCCCCCCC	35.02	20068231
1012	Phosphorylation	GSSQSSGYGQHGSSS CCCCCCCCCCCCCCC	18.63	-
1238	Phosphorylation	TVHGRQETTHGQTIN EECCEEECCCCEEEE	18.76	21406692
1239	Phosphorylation	VHGRQETTHGQTINT ECCEEECCCCEEEEC	24.21	21406692
1243	Phosphorylation	QETTHGQTINTTRHS EECCCCEEEECCCCC	22.31	21406692
1246	Phosphorylation	THGQTINTTRHSQSG CCCEEEECCCCCCCC	22.74	21406692
1247	Phosphorylation	HGQTINTTRHSQSGQ CCEEEECCCCCCCCC	23.15	21406692
1250	Phosphorylation	TINTTRHSQSGQGQS EEECCCCCCCCCCCC	23.81	-
1252	Phosphorylation	NTTRHSQSGQGQSTQ ECCCCCCCCCCCCCC	35.78	-
1257	Phosphorylation	SQSGQGQSTQTGSRV CCCCCCCCCCCCCHH	29.34	-
1262	Phosphorylation	GQSTQTGSRVTRRRR CCCCCCCCHHHHHHC	27.28	-
1265	Phosphorylation	TQTGSRVTRRRRSSQ CCCCCHHHHHHCCCC	19.83	-
1270	Phosphorylation	RVTRRRRSSQSENSD HHHHHHCCCCCCCCH	30.80	30576142
1271	Phosphorylation	VTRRRRSSQSENSDS HHHHHCCCCCCCCHH	35.59	30576142
1273	Phosphorylation	RRRRSSQSENSDSEV HHHCCCCCCCCHHHH	40.47	-
1276	Phosphorylation	RSSQSENSDSEVHSK CCCCCCCCHHHHHHH	38.16	-
1282	Phosphorylation	NSDSEVHSKVSHRHS CCHHHHHHHHHHCCC	39.67	30576142
1427	Phosphorylation	RGSGHSESSDSEVHS CCCCCCCCCCCCCCC	42.32	-
1428	Phosphorylation	GSGHSESSDSEVHSG CCCCCCCCCCCCCCC	40.90	-
1434	Phosphorylation	SSDSEVHSGGSHRPQ CCCCCCCCCCCCCCC	50.45	-
1468	Phosphorylation	VHGRHGTTHGQTGDT ECCCCCCCCCCCCCC	28.71	24719451
1472	Phosphorylation	HGTTHGQTGDTTRHA CCCCCCCCCCCCCCC	41.43	24719451
1475	Phosphorylation	THGQTGDTTRHAHYH CCCCCCCCCCCCEEE	27.37	24719451
1476	Phosphorylation	HGQTGDTTRHAHYHH CCCCCCCCCCCEEEC	25.79	24719451
1486	Phosphorylation	AHYHHGKSTQRGSST CEEECCCCCCCCCCC	34.07	24719451
1487	Phosphorylation	HYHHGKSTQRGSSTT EEECCCCCCCCCCCC	26.27	24719451
1492	Phosphorylation	KSTQRGSSTTGRRGS CCCCCCCCCCCCCCC	32.58	22964224
1493	Phosphorylation	STQRGSSTTGRRGSG CCCCCCCCCCCCCCC	34.66	24719451
1494	Phosphorylation	TQRGSSTTGRRGSGH CCCCCCCCCCCCCCC	30.55	24719451
1504	Phosphorylation	RGSGHSESSDSEVHS CCCCCCCCCCCCCCC	42.32	-
1505	Phosphorylation	GSGHSESSDSEVHSG CCCCCCCCCCCCCCC	40.90	-
1579	Phosphorylation	QRTSHSESTDSEVHS CCCCCCCCCCCCCCC	40.30	-
1619	Phosphorylation	TVHERHGTTHGQIGD EEEEECCCCCCEECC	14.97	-
1656	Phosphorylation	QRSSHSESSDSEVHS CCCCCCCCCCCCCCC	42.32	-
1657	Phosphorylation	RSSHSESSDSEVHSG CCCCCCCCCCCCCCC	40.90	-
1695	Phosphorylation	VPERHGTTHGQTGDT CCCCCCCCCCCCCCC	28.71	24719451
1699	Phosphorylation	HGTTHGQTGDTTRHA CCCCCCCCCCCCCCC	41.43	24719451
1702	Phosphorylation	THGQTGDTTRHAHYH CCCCCCCCCCCCEEE	27.37	24719451
1703	Phosphorylation	HGQTGDTTRHAHYHH CCCCCCCCCCCEEEC	25.79	24719451
1800	Phosphorylation	SRTTGRRSSGHSEYS CCCCCCCCCCCCCCC	39.03	-
1807	Phosphorylation	SSGHSEYSDSEGHSG CCCCCCCCCCCCCCC	30.52	-
1878	Phosphorylation	STTGRRRSGHSESSD CCCCCCCCCCCCCCC	38.76	22210691
1881	Phosphorylation	GRRRSGHSESSDSEV CCCCCCCCCCCCCCC	42.57	22210691
1883	Phosphorylation	RRSGHSESSDSEVHS CCCCCCCCCCCCCCC	42.32	-
1884	Phosphorylation	RSGHSESSDSEVHSG CCCCCCCCCCCCCCC	40.90	-
1902	Phosphorylation	THSGHTHSQARSQHG CCCCCCHHHHHHHCC	27.04	22210691
1926	Phosphorylation	HQTTHGQTGDTTEHG CCCCCCCCCCCCCCC	41.43	24114839
1930	Phosphorylation	HGQTGDTTEHGHPSH CCCCCCCCCCCCCCC	30.63	24114839
1936	Phosphorylation	TTEHGHPSHGQTIQT CCCCCCCCCCCEEEC	34.28	24114839
1959	Phosphorylation	GSGHSEYSDSEGPSG CCCCCCCCCCCCCCC	30.52	-
1996	Phosphorylation	SVHERHGTTHGQTAD CCCCCCCCCCCCCCC	14.97	-
1997	Phosphorylation	VHERHGTTHGQTADT CCCCCCCCCCCCCCC	28.71	-
2034	Phosphorylation	ASGHSEYSDSEGHSG CCCCCCCCCCCCCCC	30.52	-
2072	Phosphorylation	VHERHGTTHGQTGDT HHHCCCCCCCCCCCC	28.71	24719451
2076	Phosphorylation	HGTTHGQTGDTTRHA CCCCCCCCCCCCCCC	41.43	24719451
2079	Phosphorylation	THGQTGDTTRHAHSG CCCCCCCCCCCCCCC	27.37	24719451
2080	Phosphorylation	HGQTGDTTRHAHSGH CCCCCCCCCCCCCCC	25.79	24719451
2097	Phosphorylation	STQRGSRTAGRRGSG CCCCCCCCCCCCCCC	34.85	24719451
2108	Phosphorylation	RGSGHSESSDSEVHS CCCCCCCCCCCCCCC	42.32	-
2115	Phosphorylation	SSDSEVHSGVSHTHS CCCCCCCCCCCCCCC	46.17	-
2122	Phosphorylation	SGVSHTHSGHTYGQA CCCCCCCCCCCHHCC	33.16	-
2131	Phosphorylation	HTYGQARSQHGESGS CCHHCCCCCCCCCCC	29.55	21406692
2136	Phosphorylation	ARSQHGESGSAIHGR CCCCCCCCCCEECCC	42.51	21406692
2138	Phosphorylation	SQHGESGSAIHGRQG CCCCCCCCEECCCCC	33.07	21406692
2165	Phosphorylation	GQSGHGQSTQTGSRT CCCCCCCCCCCCCCC	27.37	-
2173	Phosphorylation	TQTGSRTTGRQRSSH CCCCCCCCCCCCCCC	29.29	-
2258	Phosphorylation	RGSGHSESSDSEVHS CCCCCCCCCCCCCEE	42.32	-
2289	Phosphorylation	QQRQPGSTVHGRLET CCCCCCCEEEEEEEC	23.57	20068231
2310	Phosphorylation	DTTRHGHSGYGQSTQ CCCCCCCCCCCCCCC	38.00	-
2312	Phosphorylation	TRHGHSGYGQSTQTG CCCCCCCCCCCCCCC	18.27	-
2326	Phosphorylation	GSRSSRASHFQSHSS CCCCCCHHCCCCCCC	24.59	-
2340	Phosphorylation	SERQRHGSSQVWKHG CCHHHCCCCCHHHCC	16.09	-
2341	Phosphorylation	ERQRHGSSQVWKHGS CHHHCCCCCHHHCCC	33.09	20068231
2356	Phosphorylation	YGPAEYDYGHTGYGP CCCCCCCCCCCCCCC	15.20	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FILA2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FILA2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FILA2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of FILA2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.