I15RA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: I15RA_HUMAN
• UniProt AC: Q13261
• Protein Name: Interleukin-15 receptor subunit alpha
• Gene Name: IL15RA
• Organism: Homo sapiens (Human).
• Sequence Length: 267
• Subcellular Localization: Membrane ; Single-pass type I membrane protein . Nucleus membrane ; Single-pass type I membrane protein . Mainly found associated with the nuclear membrane.; Isoform 5: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi appara
• Protein Description: High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves SYK..
• Protein Sequence: MAPRRARGCRTLGLPALLLLLLLRPPATRGITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSTVTTAGVTPQPESLSPSGKEPAASSPSSNNTAATTAAIVPGSQLMPSKSPSTGTTEISSHESSHGTPSQTTAKNWELTASASHQPPGVYPQGHSDTTVAISTSTVLLCGLSAVSLLACYLKSRQTPPLASVEMEAMEALPVTWGTSSRDEDLENCSHHL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
53	Phosphorylation	VKSYSLYSRERYICN EEECCCCCCCEEECC	32.72	24719451
116	O-linked_Glycosylation	TVTTAGVTPQPESLS CEECCCCCCCCCCCC	18.45	OGP
121	O-linked_Glycosylation	GVTPQPESLSPSGKE CCCCCCCCCCCCCCC	40.61	OGP
137	N-linked_Glycosylation	AASSPSSNNTAATTA CCCCCCCCCCCCCCE	54.96	UniProtKB CARBOHYD
227	Phosphorylation	AVSLLACYLKSRQTP HHHHHHHHHHCCCCC	16.14	11714793

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of I15RA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of I15RA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of I15RA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RECO_HUMAN	RCVRN	physical	21988832
PIAS4_HUMAN	PIAS4	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.