dbPTM

MPIP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MPIP1_HUMAN
UniProt AC	P30304
Protein Name	M-phase inducer phosphatase 1
Gene Name	CDC25A
Organism	Homo sapiens (Human).
Sequence Length	524
Subcellular Localization
Protein Description	Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro..
Protein Sequence	MELGPEPPHRRRLLFACSPPPASQPVVKALFGASAAGGLSPVTNLTVTMDQLQGLGSDYEQPLEVKNNSNLQRMGSSESTDSGFCLDSPGPLDSKENLENPMRRIHSLPQKLLGCSPALKRSHSDSLDHDIFQLIDPDENKENEAFEFKKPVRPVSRGCLHSHGLQEGKDLFTQRQNSAPARMLSSNERDSSEPGNFIPLFTPQSPVTATLSDEDDGFVDLLDGENLKNEEETPSCMASLWTAPLVMRTTNLDNRCKLFDSPSLCSSSTRSVLKRPERSQEESPPGSTKRRKSMSGASPKESTNPEKAHETLHQSLSLASSPKGTIENILDNDPRDLIGDFSKGYLFHTVAGKHQDLKYISPEIMASVLNGKFANLIKEFVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKKPIVPTDGKRVIVVFHCEFSSERGPRMCRYVRERDRLGNEYPKLHYPELYVLKGGYKEFFMKCQSYCEPPSYRPMHHEDFKEDLKKFRTKSRTWAGEKSKREMYSRLKKL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18 (in isoform 2)	Phosphorylation	-	36.69	-
18	Phosphorylation	RRLLFACSPPPASQP CEEEEEECCCCCCHH	36.69	12411508
23	Phosphorylation	ACSPPPASQPVVKAL EECCCCCCHHHHHHH	40.57	26074081
40	Phosphorylation	ASAAGGLSPVTNLTV CCCCCCCCCCCEEEE	22.16	22210691
43	Phosphorylation	AGGLSPVTNLTVTMD CCCCCCCCEEEEEHH	28.09	22210691
46	Phosphorylation	LSPVTNLTVTMDQLQ CCCCCEEEEEHHHHC	18.92	22210691
59	Phosphorylation	LQGLGSDYEQPLEVK HCCCCCCCCCCCEEC	20.40	22210691
66	Ubiquitination	YEQPLEVKNNSNLQR CCCCCEECCCCCCCC	40.82	-
69	O-linked_Glycosylation	PLEVKNNSNLQRMGS CCEECCCCCCCCCCC	48.59	30379171
76 (in isoform 2)	Phosphorylation	-	22.91	-
76	Phosphorylation	SNLQRMGSSESTDSG CCCCCCCCCCCCCCC	22.91	12963847
77	Phosphorylation	NLQRMGSSESTDSGF CCCCCCCCCCCCCCC	29.81	28348404
79	Phosphorylation	QRMGSSESTDSGFCL CCCCCCCCCCCCCCC	39.19	22817900
80	Phosphorylation	RMGSSESTDSGFCLD CCCCCCCCCCCCCCC	30.08	18167338
82	Phosphorylation	GSSESTDSGFCLDSP CCCCCCCCCCCCCCC	33.58	14603323
88	Phosphorylation	DSGFCLDSPGPLDSK CCCCCCCCCCCCCCH	20.86	14603323
107	Phosphorylation	NPMRRIHSLPQKLLG CHHHHHHHHHHHHHC	39.10	23917254
111	Ubiquitination	RIHSLPQKLLGCSPA HHHHHHHHHHCCCHH	43.68	-
116	Phosphorylation	PQKLLGCSPALKRSH HHHHHCCCHHHHHCC	16.06	12411508
116 (in isoform 2)	Phosphorylation	-	16.06	-
120	Ubiquitination	LGCSPALKRSHSDSL HCCCHHHHHCCCCCC	54.70	-
122	Phosphorylation	CSPALKRSHSDSLDH CCHHHHHCCCCCCCC	26.25	21406692
124	Phosphorylation	PALKRSHSDSLDHDI HHHHHCCCCCCCCCH	30.09	12759351
124 (in isoform 2)	Phosphorylation	-	30.09	-
126	Phosphorylation	LKRSHSDSLDHDIFQ HHHCCCCCCCCCHHH	38.42	20363803
141	Ubiquitination	LIDPDENKENEAFEF HCCCCCCCCCCCCCC	60.93	14681206PubMed
150	Acetylation	NEAFEFKKPVRPVSR CCCCCCCCCCCCCCC	54.81	113686999
150	Ubiquitination	NEAFEFKKPVRPVSR CCCCCCCCCCCCCCC	54.81	-
169	Ubiquitination	SHGLQEGKDLFTQRQ HCCCHHCHHHHHHCC	50.97	-
178	Phosphorylation	LFTQRQNSAPARMLS HHHHCCCCCCHHHHC	27.56	25159151
239	Phosphorylation	ETPSCMASLWTAPLV CCHHHHHHHHHHCEE	9.50	12676583
239 (in isoform 2)	Phosphorylation	-	9.50	-
253 (in isoform 2)	Phosphorylation	-	42.47	-
257	Ubiquitination	TNLDNRCKLFDSPSL CCCCCCCEECCCCCC	49.29	-
261	Phosphorylation	NRCKLFDSPSLCSSS CCCEECCCCCCCCCC	14.73	21815630
263	Phosphorylation	CKLFDSPSLCSSSTR CEECCCCCCCCCCHH	46.06	25850435
266	Phosphorylation	FDSPSLCSSSTRSVL CCCCCCCCCCHHHHH	32.39	25627689
267	Phosphorylation	DSPSLCSSSTRSVLK CCCCCCCCCHHHHHC	34.43	25627689
278	Dimethylation	SVLKRPERSQEESPP HHHCCCCCCCCCCCC	46.45	-
279	Phosphorylation	VLKRPERSQEESPPG HHCCCCCCCCCCCCC	40.04	22817900
283	Phosphorylation	PERSQEESPPGSTKR CCCCCCCCCCCCHHH	35.33	21815630
287	Phosphorylation	QEESPPGSTKRRKSM CCCCCCCCHHHHHHC	36.21	28102081
288	Phosphorylation	EESPPGSTKRRKSMS CCCCCCCHHHHHHCC	34.19	28102081
290	Dimethylation	SPPGSTKRRKSMSGA CCCCCHHHHHHCCCC	51.88	-
293	Phosphorylation	GSTKRRKSMSGASPK CCHHHHHHCCCCCCC	19.17	28985074
295	Phosphorylation	TKRRKSMSGASPKES HHHHHHCCCCCCCCC	37.99	28102081
298	Phosphorylation	RKSMSGASPKESTNP HHHCCCCCCCCCCCH	39.78	28102081
300	Ubiquitination	SMSGASPKESTNPEK HCCCCCCCCCCCHHH	62.90	-
303 (in isoform 2)	Ubiquitination	-	56.75	21906983
315	Phosphorylation	AHETLHQSLSLASSP HHHHHHHHHHHHCCC	14.80	26074081
317	Phosphorylation	ETLHQSLSLASSPKG HHHHHHHHHHCCCCC	27.43	26074081
320	Phosphorylation	HQSLSLASSPKGTIE HHHHHHHCCCCCHHH	53.09	25159151
321	Phosphorylation	QSLSLASSPKGTIEN HHHHHHCCCCCHHHH	25.64	30576142
342	Phosphorylation	RDLIGDFSKGYLFHT HHHHHHCCCCCHHEC	29.88	28348404
343	Ubiquitination	DLIGDFSKGYLFHTV HHHHHCCCCCHHECC	52.12	2190698
343 (in isoform 1)	Ubiquitination	-	52.12	21906983
349	Phosphorylation	SKGYLFHTVAGKHQD CCCCHHECCCCCCCC	12.52	28348404
353	Ubiquitination	LFHTVAGKHQDLKYI HHECCCCCCCCCCCC	28.49	-
358	Ubiquitination	AGKHQDLKYISPEIM CCCCCCCCCCCHHHH	49.15	-
359	Phosphorylation	GKHQDLKYISPEIMA CCCCCCCCCCHHHHH	17.58	-
361	Phosphorylation	HQDLKYISPEIMASV CCCCCCCCHHHHHHH	17.25	-
367	Phosphorylation	ISPEIMASVLNGKFA CCHHHHHHHHCCHHH	15.12	-
372	Ubiquitination	MASVLNGKFANLIKE HHHHHCCHHHHHCEE	39.98	-
378	Ubiquitination	GKFANLIKEFVIIDC CHHHHHCEEEEEEEC	48.54	-
415	Ubiquitination	VEDFLLKKPIVPTDG HHHHHHCCCCCCCCC	39.69	-
423	Ubiquitination	PIVPTDGKRVIVVFH CCCCCCCCEEEEEEE	46.42	-
471	Ubiquitination	YVLKGGYKEFFMKCQ EEEECCHHHHHHHHH	51.85	-
486	Phosphorylation	SYCEPPSYRPMHHED HHCCCCCCCCCCHHH	25.22	-
505	Phosphorylation	LKKFRTKSRTWAGEK HHHHHHHCCCCCCHH	34.04	23312004
507	Phosphorylation	KFRTKSRTWAGEKSK HHHHHCCCCCCHHHH	27.10	30576142
513	Phosphorylation	RTWAGEKSKREMYSR CCCCCHHHHHHHHHH	32.42	21376736
518	Phosphorylation	EKSKREMYSRLKKL- HHHHHHHHHHHHCC-	5.96	22210691
519	Phosphorylation	KSKREMYSRLKKL-- HHHHHHHHHHHCC--	29.81	21376736

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
18	S	Phosphorylation	Kinase	CDK1	P06493	PSP
40	S	Phosphorylation	Kinase	CDK4	P11802	PSP
59	Y	Phosphorylation	Kinase	SRC	P12931	PSP
76	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
76	S	Phosphorylation	Kinase	CHK1	O14757	PSP
79	S	Phosphorylation	Kinase	NEK11	Q8NG66	Uniprot
79	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
80	T	Phosphorylation	Kinase	PLK3	Q9H4B4	PSP
82	S	Phosphorylation	Kinase	NEK11	Q8NG66	Uniprot
82	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
88	S	Phosphorylation	Kinase	NEK11	Q8NG66	Uniprot
116	S	Phosphorylation	Kinase	PIM1	P11309	PhosphoELM
116	S	Phosphorylation	Kinase	CDK1	P06493	PSP
124	S	Phosphorylation	Kinase	CHK1	O14757	PSP
124	S	Phosphorylation	Kinase	CHK2	O96017	PSP
178	S	Phosphorylation	Kinase	CHEK2	O96017	GPS
178	S	Phosphorylation	Kinase	CHK1	O14757	PSP
279	S	Phosphorylation	Kinase	CHK2	O96017	PSP
279	S	Phosphorylation	Kinase	CHK1	O14757	PSP
283	S	Phosphorylation	Kinase	CDK1	P06493	PSP
283	S	Phosphorylation	Kinase	CDK2	P24941	PSP
293	S	Phosphorylation	Kinase	CHK2	O96017	PSP
293	S	Phosphorylation	Kinase	RPS6KA1	Q15418	GPS
293	S	Phosphorylation	Kinase	CHK1	O14757	PSP
295	S	Phosphorylation	Kinase	RPS6KA1	Q15418	GPS
486	Y	Phosphorylation	Kinase	SRC	P12931	PSP
507	T	Phosphorylation	Kinase	CHK1	O14757	PSP
513	S	Phosphorylation	Kinase	PLK3	Q9H4B4	Uniprot
513	S	Phosphorylation	Kinase	PLK3	Q60806	PSP
519	S	Phosphorylation	Kinase	PLK3	Q9H4B4	Uniprot
519	S	Phosphorylation	Kinase	PLK3	Q60806	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	FZR1	Q9UM11	PMID:12234927
-	K	Ubiquitination	E3 ubiquitin ligase	FBXW11	Q9UKB1	PMID:14681206
-	K	Ubiquitination	E3 ubiquitin ligase	BTRC	Q9Y297	PMID:14681206

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
76	S	ubiquitylation	14681206
Phosphorylation on Ser-76, Ser-124, Ser-178, Ser-279 and Ser-293 may also promote ubiquitin-dependent proteolysis of CDC25A by the SCF complex.
76	S	Phosphorylation	14681206
Phosphorylation on Ser-76, Ser-124, Ser-178, Ser-279 and Ser-293 may also promote ubiquitin-dependent proteolysis of CDC25A by the SCF complex.
76	S	Phosphorylation	14681206
Phosphorylation of CDC25A at Ser-76 by CHEK1 primes it for subsequent phosphorylation at Ser-79, Ser-82 and Ser-88 by NEK11.
76	S	Phosphorylation	14681206
Phosphorylated by CHEK1 on Ser-76, Ser-124, Ser-178, Ser-279, Ser-293 and Thr-507 during checkpoint mediated cell cycle arrest.
79	S	Phosphorylation	14681206
Phosphorylation of CDC25A at Ser-76 by CHEK1 primes it for subsequent phosphorylation at Ser-79, Ser-82 and Ser-88 by NEK11.
82	S	Phosphorylation	14681206
Phosphorylation of CDC25A at Ser-76 by CHEK1 primes it for subsequent phosphorylation at Ser-79, Ser-82 and Ser-88 by NEK11.
88	S	Phosphorylation	19734889
Phosphorylation of CDC25A at Ser-76 by CHEK1 primes it for subsequent phosphorylation at Ser-79, Ser-82 and Ser-88 by NEK11.
124	S	Phosphorylation	11298456
Phosphorylated by CHEK1 on Ser-76, Ser-124, Ser-178, Ser-279, Ser-293 and Thr-507 during checkpoint mediated cell cycle arrest.
124	S	Phosphorylation	11298456
Also phosphorylated by CHEK2 on Ser-124, Ser-279, and Ser-293 during checkpoint mediated cell cycle arrest.
124	S	ubiquitylation	11298456
Phosphorylation on Ser-76, Ser-124, Ser-178, Ser-279 and Ser-293 may also promote ubiquitin-dependent proteolysis of CDC25A by the SCF complex.
124	S	Phosphorylation	11298456
Phosphorylation on Ser-76, Ser-124, Ser-178, Ser-279 and Ser-293 may also promote ubiquitin-dependent proteolysis of CDC25A by the SCF complex.
178	S	ubiquitylation	12676583
Phosphorylation on Ser-76, Ser-124, Ser-178, Ser-279 and Ser-293 may also promote ubiquitin-dependent proteolysis of CDC25A by the SCF complex.
178	S	Phosphorylation	12676583
Phosphorylation on Ser-76, Ser-124, Ser-178, Ser-279 and Ser-293 may also promote ubiquitin-dependent proteolysis of CDC25A by the SCF complex.
178	S	Phosphorylation	12676583
Phosphorylation on Ser-178 and Thr-507 creates binding sites for YWHAE/14-3-3 epsilon which inhibits CDC25A.
178	S	Phosphorylation	12676583
Phosphorylated by CHEK1 on Ser-76, Ser-124, Ser-178, Ser-279, Ser-293 and Thr-507 during checkpoint mediated cell cycle arrest.
279	S	Phosphorylation	12676583
Phosphorylated by CHEK1 on Ser-76, Ser-124, Ser-178, Ser-279, Ser-293 and Thr-507 during checkpoint mediated cell cycle arrest.
279	S	Phosphorylation	12676583
Phosphorylation on Ser-76, Ser-124, Ser-178, Ser-279 and Ser-293 may also promote ubiquitin-dependent proteolysis of CDC25A by the SCF complex.
279	S	ubiquitylation	12676583
Phosphorylation on Ser-76, Ser-124, Ser-178, Ser-279 and Ser-293 may also promote ubiquitin-dependent proteolysis of CDC25A by the SCF complex.
279	S	Phosphorylation	12676583
Also phosphorylated by CHEK2 on Ser-124, Ser-279, and Ser-293 during checkpoint mediated cell cycle arrest.
293	S	Phosphorylation	12676583
Also phosphorylated by CHEK2 on Ser-124, Ser-279, and Ser-293 during checkpoint mediated cell cycle arrest.
293	S	ubiquitylation	12676583
Phosphorylation on Ser-76, Ser-124, Ser-178, Ser-279 and Ser-293 may also promote ubiquitin-dependent proteolysis of CDC25A by the SCF complex.
293	S	Phosphorylation	12676583
Phosphorylation on Ser-76, Ser-124, Ser-178, Ser-279 and Ser-293 may also promote ubiquitin-dependent proteolysis of CDC25A by the SCF complex.
293	S	Phosphorylation	12676583
Phosphorylated by CHEK1 on Ser-76, Ser-124, Ser-178, Ser-279, Ser-293 and Thr-507 during checkpoint mediated cell cycle arrest.
507	T	Phosphorylation	14559997
Phosphorylated by CHEK1 on Ser-76, Ser-124, Ser-178, Ser-279, Ser-293 and Thr-507 during checkpoint mediated cell cycle arrest.
507	T	Phosphorylation	14559997
Phosphorylation on Ser-178 and Thr-507 creates binding sites for YWHAE/14-3-3 epsilon which inhibits CDC25A.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MPIP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NAA10_HUMAN	NAA10	physical	16189514
CCNE1_HUMAN	CCNE1	physical	8617791
CDK2_HUMAN	CDK2	physical	8617791
M3K5_HUMAN	MAP3K5	physical	11416155
EGFR_HUMAN	EGFR	physical	11912208
CCNB1_HUMAN	CCNB1	physical	1836978
CHK1_HUMAN	CHEK1	physical	9278511
RAF1_HUMAN	RAF1	physical	7744247
1433B_HUMAN	YWHAB	physical	7644510
1433E_HUMAN	YWHAE	physical	7644510
FBW1B_HUMAN	FBXW11	physical	15798217
CUL1_HUMAN	CUL1	physical	14681206
FBW1A_HUMAN	BTRC	physical	14681206
FBW1B_HUMAN	FBXW11	physical	14681206
DUS8_HUMAN	DUSP8	physical	21900206
F193B_HUMAN	FAM193B	physical	21900206
FBW1A_HUMAN	BTRC	physical	20348946
CUL1_HUMAN	CUL1	physical	14752276
SKP1_HUMAN	SKP1	physical	14752276
FBW1A_HUMAN	BTRC	physical	14752276
TRIB3_HUMAN	TRIB3	physical	20606298
FBW1B_HUMAN	FBXW11	physical	16338364
FBW1A_HUMAN	BTRC	physical	16338364
A4_HUMAN	APP	physical	21832049
FBW1A_HUMAN	BTRC	physical	14603323
FBW1B_HUMAN	FBXW11	physical	14603323
CUL1_HUMAN	CUL1	physical	14603323
SKP1_HUMAN	SKP1	physical	14603323
1C07_HUMAN	HLA-C	physical	21988832
FGF21_HUMAN	FGF21	physical	21988832
EF1A1_HUMAN	EEF1A1	physical	21988832
IL3RA_HUMAN	IL3RA	physical	21988832
FRIH_HUMAN	FTH1	physical	21988832
PEX19_HUMAN	PEX19	physical	21988832
SCYL1_HUMAN	SCYL1	physical	21988832
DMD_HUMAN	DMD	physical	21988832
RBTN2_HUMAN	LMO2	physical	21988832
SMAD3_HUMAN	SMAD3	physical	21988832
MTAP_HUMAN	MTAP	physical	21988832
IKBB_HUMAN	NFKBIB	physical	21988832
NFYA_HUMAN	NFYA	physical	21988832
SOX5_HUMAN	SOX5	physical	21988832
XPO1_HUMAN	XPO1	physical	21988832
CUL3_HUMAN	CUL3	physical	21988832
VAMP8_HUMAN	VAMP8	physical	21988832
GANP_HUMAN	MCM3AP	physical	21988832
NPL4_HUMAN	NPLOC4	physical	24429874
TERA_HUMAN	VCP	physical	24429874
SKP1_HUMAN	SKP1	physical	12234927
CUL1_HUMAN	CUL1	physical	12234927
CUL1_HUMAN	CUL1	physical	15536641
FBW1A_HUMAN	BTRC	physical	15536641
SKP1_HUMAN	SKP1	physical	15536641
KPYM_HUMAN	PKM	physical	27485204
FBW1A_HUMAN	BTRC	physical	27880917
FBW1B_HUMAN	FBXW11	physical	27880917
MPIP1_HUMAN	CDC25A	physical	27432908
CC28A_HUMAN	CCDC28A	physical	27432908
FBW1B_HUMAN	FBXW11	physical	27432908
CCNA2_HUMAN	CCNA2	physical	27432908
CDK2_HUMAN	CDK2	physical	27432908
APLD1_HUMAN	APOLD1	physical	27432908
TP4A1_HUMAN	PTP4A1	physical	27432908
CCNB1_HUMAN	CCNB1	physical	27432908
GOPC_HUMAN	GOPC	physical	27432908
1433F_HUMAN	YWHAH	physical	27432908
1433S_HUMAN	SFN	physical	27432908
CCNA1_HUMAN	CCNA1	physical	27432908
WDR11_HUMAN	WDR11	physical	27432908
F91A1_HUMAN	FAM91A1	physical	27432908
CUL1_HUMAN	CUL1	physical	27432908
CHK1_HUMAN	CHEK1	physical	27432908
CDK3_HUMAN	CDK3	physical	27432908
RD23A_HUMAN	RAD23A	physical	27432908
1433G_HUMAN	YWHAG	physical	27432908
CDC20_HUMAN	CDC20	physical	27432908
STIP1_HUMAN	STIP1	physical	27432908
A7L3B_HUMAN	ATXN7L3B	physical	27432908
DJC10_HUMAN	DNAJC10	physical	27432908
SKP1_HUMAN	SKP1	physical	27432908
1433B_HUMAN	YWHAB	physical	27432908
GTF2I_HUMAN	GTF2I	physical	27432908
IPO5_HUMAN	IPO5	physical	27432908
1433Z_HUMAN	YWHAZ	physical	27432908
DUS7_HUMAN	DUSP7	physical	27432908
FBW1A_HUMAN	BTRC	physical	28514442
FBW1B_HUMAN	FBXW11	physical	28514442
UBE4B_HUMAN	UBE4B	physical	28514442
1433Z_HUMAN	YWHAZ	physical	28514442
FBW1B_HUMAN	FBXW11	physical	29150431

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MPIP1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Absence of polo-like kinase 3 in mice stabilizes Cdc25A after DNAdamage but is not sufficient to produce tumors."; Myer D.L., Robbins S.B., Yin M., Boivin G.P., Liu Y., Greis K.D.,Bahassi el M., Stambrook P.J.; Mutat. Res. 714:1-10(2011). Cited for: PHOSPHORYLATION AT SER-513 AND SER-519 BY PLK3, UBIQUITINATION, ANDMUTAGENESIS OF SER-513 AND SER-519.	21376736 [Abstract]
"NEK11: linking CHK1 and CDC25A in DNA damage checkpoint signaling."; Soerensen C.S., Melixetian M., Klein D.K., Helin K.; Cell Cycle 9:450-455(2010). Cited for: PHOSPHORYLATION AT SER-82 AND SER-88.	20090422 [Abstract]
"NEK11 regulates CDC25A degradation and the IR-induced G2/Mcheckpoint."; Melixetian M., Klein D.K., Soerensen C.S., Helin K.; Nat. Cell Biol. 11:1247-1253(2009). Cited for: PHOSPHORYLATION AT SER-79; SER-82 AND SER-88.	19734889 [Abstract]
"Chk1 kinase negatively regulates mitotic function of Cdc25Aphosphatase through 14-3-3 binding."; Chen M.-S., Ryan C.E., Piwnica-Worms H.; Mol. Cell. Biol. 23:7488-7497(2003). Cited for: INTERACTION WITH CCNB1 AND YWHAE, PHOSPHORYLATION AT SER-178 ANDTHR-507, AND MUTAGENESIS OF SER-178; CYS-431; THR-507; LYS-514 ANDARG-520.	14559997 [Abstract]
"Phosphorylation at serine 75 is required for UV-mediated degradationof human Cdc25A phosphatase at the S-phase checkpoint."; Hassepass I., Voit R., Hoffmann I.; J. Biol. Chem. 278:29824-29829(2003). Cited for: PHOSPHORYLATION AT SER-76; SER-124 AND SER-178, AND MUTAGENESIS OFSER-76; SER-124 AND SER-178.	12759351 [Abstract]
"SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25Aprotein phosphatase."; Jin J., Shirogane T., Xu L., Nalepa G., Qin J., Elledge S.J.,Harper J.W.; Genes Dev. 17:3062-3074(2003). Cited for: INTERACTION WITH BTRC; CUL1 AND FBXW11, PHOSPHODEGRON MOTIF,PHOSPHORYLATION AT SER-76 AND SER-124, UBIQUITINATION, AND MUTAGENESISOF SER-76; SER-79; ASP-81 AND SER-82.	14681206 [Abstract]
"Chk1 regulates the S phase checkpoint by coupling the physiologicalturnover and ionizing radiation-induced accelerated proteolysis ofCdc25A."; Soerensen C.S., Syljuaesen R.G., Falck J., Schroeder T.,Roennstrand L., Khanna K.K., Zhou B.-B., Bartek J., Lukas J.; Cancer Cell 3:247-258(2003). Cited for: PHOSPHORYLATION AT SER-124; SER-178; SER-279 AND SER-293, ANDMUTAGENESIS OF SER-124; SER-178; SER-279 AND SER-293.	12676583 [Abstract]
"Disruption of the checkpoint kinase 1/cell division cycle 25A pathwayabrogates ionizing radiation-induced S and G2 checkpoints."; Zhao H., Watkins J.L., Piwnica-Worms H.; Proc. Natl. Acad. Sci. U.S.A. 99:14795-14800(2002). Cited for: PHOSPHORYLATION AT SER-124, AND MUTAGENESIS OF SER-124.	12399544 [Abstract]
"The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistantDNA synthesis."; Falck J., Mailand N., Syljuaasen R.G., Bartek J., Lukas J.; Nature 410:842-847(2001). Cited for: INTERACTION WITH CHEK2, PHOSPHORYLATION AT SER-124 BY CHEK2, ANDMUTAGENESIS OF SER-124.	11298456 [Abstract]

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