| UniProt ID | DUS8_HUMAN | |
|---|---|---|
| UniProt AC | Q13202 | |
| Protein Name | Dual specificity protein phosphatase 8 | |
| Gene Name | DUSP8 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 625 | |
| Subcellular Localization | Cytoplasm . Nucleus . | |
| Protein Description | Has phosphatase activity with synthetic phosphatase substrates and negatively regulates mitogen-activated protein kinase activity, presumably by catalysing their dephosphorylation. Expected to display protein phosphatase activity toward phosphotyrosine, phosphoserine and phosphothreonine residues.. | |
| Protein Sequence | MAGDRLPRKVMDAKKLASLLRGGPGGPLVIDSRSFVEYNSWHVLSSVNICCSKLVKRRLQQGKVTIAELIQPAARSQVEATEPQDVVVYDQSTRDASVLAADSFLSILLSKLDGCFDSVAILTGGFATFSSCFPGLCEGKPAALLPMSLSQPCLPVPSVGLTRILPHLYLGSQKDVLNKDLMTQNGISYVLNASNSCPKPDFICESRFMRVPINDNYCEKLLPWLDKSIEFIDKAKLSSCQVIVHCLAGISRSATIAIAYIMKTMGMSSDDAYRFVKDRRPSISPNFNFLGQLLEYERSLKLLAALQGDPGTPSGTPEPPPSPAAGAPLPRLPPPTSESAATGNAAAREGGLSAGGEPPAPPTPPATSALQQGLRGLHLSSDRLQDTNRLKRSFSLDIKSAYAPSRRPDGPGPPDPGEAPKLCKLDSPSGAALGLSSPSPDSPDAAPEARPRPRRRPRPPAGSPARSPAHSLGLNFGDAARQTPRHGLSALSAPGLPGPGQPAGPGAWAPPLDSPGTPSPDGPWCFSPEGAQGAGGVLFAPFGRAGAPGPGGGSDLRRREAARAEPRDARTGWPEEPAPETQFKRRSCQMEFEEGMVEGRARGEELAALGKQASFSGSVEVIEVS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 18 | Phosphorylation | MDAKKLASLLRGGPG HCHHHHHHHHHCCCC | 38.07 | 27174698 | |
| 32 | Phosphorylation | GGPLVIDSRSFVEYN CCCEEEECCCCEEEC | 20.78 | 27174698 | |
| 264 | Phosphorylation | AIAYIMKTMGMSSDD HHHHHHHHHCCCHHH | 11.11 | 25219547 | |
| 268 | Phosphorylation | IMKTMGMSSDDAYRF HHHHHCCCHHHHHHH | 25.53 | 25219547 | |
| 269 | Phosphorylation | MKTMGMSSDDAYRFV HHHHCCCHHHHHHHH | 30.53 | 25219547 | |
| 273 | Phosphorylation | GMSSDDAYRFVKDRR CCCHHHHHHHHHCCC | 16.16 | 25219547 | |
| 312 | Phosphorylation | ALQGDPGTPSGTPEP HHHCCCCCCCCCCCC | 21.48 | 23312004 | |
| 314 | Phosphorylation | QGDPGTPSGTPEPPP HCCCCCCCCCCCCCC | 55.95 | 23312004 | |
| 316 | Phosphorylation | DPGTPSGTPEPPPSP CCCCCCCCCCCCCCC | 28.90 | 23312004 | |
| 322 | Phosphorylation | GTPEPPPSPAAGAPL CCCCCCCCCCCCCCC | 32.70 | 23312004 | |
| 380 | Phosphorylation | GLRGLHLSSDRLQDT HCCCCCCCCHHHHCC | 21.31 | 28555341 | |
| 393 | Phosphorylation | DTNRLKRSFSLDIKS CCCHHHHHCCCCCCH | 20.01 | 29514088 | |
| 395 | Phosphorylation | NRLKRSFSLDIKSAY CHHHHHCCCCCCHHC | 26.78 | 25159151 | |
| 554 | Phosphorylation | APGPGGGSDLRRREA CCCCCCHHHHHHHHH | 36.42 | 21815630 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DUS8_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DUS8_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DUS8_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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