dbPTM

DUS16_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DUS16_HUMAN
UniProt AC	Q9BY84
Protein Name	Dual specificity protein phosphatase 16
Gene Name	DUSP16
Organism	Homo sapiens (Human).
Sequence Length	665
Subcellular Localization	Cytoplasm. Nucleus. Cytoplasmic vesicle. After dissociation upon AGTR stimulation, re-associates with ARRB2 on endocytic vesicles.
Protein Description	Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2..
Protein Sequence	MAHEMIGTQIVTERLVALLESGTEKVLLIDSRPFVEYNTSHILEAININCSKLMKRRLQQDKVLITELIQHSAKHKVDIDCSQKVVVYDQSSQDVASLSSDCFLTVLLGKLEKSFNSVHLLAGGFAEFSRCFPGLCEGKSTLVPTCISQPCLPVANIGPTRILPNLYLGCQRDVLNKELMQQNGIGYVLNASNTCPKPDFIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATIAIAYIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKKIKNQTGASGPKSKLKLLHLEKPNEPVPAVSEGGQKSETPLSPPCADSATSEAAGQRPVHPASVPSVPSVQPSLLEDSPLVQALSGLHLSADRLEDSNKLKRSFSLDIKSVSYSASMAASLHGFSSSEDALEYYKPSTTLDGTNKLCQFSPVQELSEQTPETSPDKEEASIPKKLQTARPSDSQSKRLHSVRTSSSGTAQRSLLSPLHRSGSVEDNYHTSFLFGLSTSQQHLTKSAGLGLKGWHSDILAPQTSTPSLTSSWYFATESSHFYSASAIYGGSASYSAYSCSQLPTCGDQVYSVRRRQKPSDRADSRRSWHEESPFEKQFKRRSCQMEFGESIMSENRSREELGKVGSQSSFSGSMEIIEVS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MAHEMIGTQIVTERL CCCCHHCCHHHHHHH	12.28	24043423
12	Phosphorylation	MIGTQIVTERLVALL HHCCHHHHHHHHHHH	19.60	24043423
55	Acetylation	INCSKLMKRRLQQDK CCHHHHHHHHHHHCH	44.81	22547814
82	Phosphorylation	HKVDIDCSQKVVVYD CCCCCCCCCCEEEEE	29.32	-
145	Phosphorylation	GKSTLVPTCISQPCL CCCCCCEEECCCCCC	18.26	28348404
148	Phosphorylation	TLVPTCISQPCLPVA CCCEEECCCCCCCCC	30.16	24719451
218	Ubiquitination	VNDSFCEKILPWLDK CCCHHHHHHHHHHHH	51.21	-
225	Ubiquitination	KILPWLDKSVDFIEK HHHHHHHHCHHHHHH	50.65	-
232	Ubiquitination	KSVDFIEKAKASNGC HCHHHHHHHHHCCCE	50.82	-
399	Phosphorylation	DSNKLKRSFSLDIKS CCCCHHHEEEEECCE	20.01	29514088
401	Phosphorylation	NKLKRSFSLDIKSVS CCHHHEEEEECCEEE	26.78	25159151
446	Phosphorylation	TNKLCQFSPVQELSE CCCCCCCCCHHHHHH	9.78	30266825
452	Phosphorylation	FSPVQELSEQTPETS CCCHHHHHHCCCCCC	27.23	30266825
455	Phosphorylation	VQELSEQTPETSPDK HHHHHHCCCCCCCCH	21.02	30266825
458	Phosphorylation	LSEQTPETSPDKEEA HHHCCCCCCCCHHHC	46.92	30266825
459	Phosphorylation	SEQTPETSPDKEEAS HHCCCCCCCCHHHCC	29.46	30266825
466	Phosphorylation	SPDKEEASIPKKLQT CCCHHHCCCCHHHHC	42.58	27251275
473	Phosphorylation	SIPKKLQTARPSDSQ CCCHHHHCCCCCCHH	34.76	25072903
477	Phosphorylation	KLQTARPSDSQSKRL HHHCCCCCCHHHCCC	44.32	25072903
479	Phosphorylation	QTARPSDSQSKRLHS HCCCCCCHHHCCCEE	40.46	25072903
481	Phosphorylation	ARPSDSQSKRLHSVR CCCCCHHHCCCEEEE	24.56	25072903
498	Phosphorylation	SSGTAQRSLLSPLHR CCCHHHHHHCCCCCC	22.91	23403867
501	Phosphorylation	TAQRSLLSPLHRSGS HHHHHHCCCCCCCCC	30.61	23898821
506	Phosphorylation	LLSPLHRSGSVEDNY HCCCCCCCCCCCCCC	25.36	24719451
508	Phosphorylation	SPLHRSGSVEDNYHT CCCCCCCCCCCCCCH	24.47	28857561
515	Phosphorylation	SVEDNYHTSFLFGLS CCCCCCCHHHHCCCC	15.71	28348404
516	Phosphorylation	VEDNYHTSFLFGLST CCCCCCHHHHCCCCC	13.46	28348404
604	Phosphorylation	VRRRQKPSDRADSRR HHCCCCCCCCCHHHH	46.92	-
609	Phosphorylation	KPSDRADSRRSWHEE CCCCCCHHHHCCCCC	28.71	23403867
612	Phosphorylation	DRADSRRSWHEESPF CCCHHHHCCCCCCHH	31.51	30266825
617	Phosphorylation	RRSWHEESPFEKQFK HHCCCCCCHHHHHHH	31.72	26330541
627	Phosphorylation	EKQFKRRSCQMEFGE HHHHHHHHHHHHHHH	16.85	30576142
635	Phosphorylation	CQMEFGESIMSENRS HHHHHHHHHHCCCCC	24.78	28348404
638	Phosphorylation	EFGESIMSENRSREE HHHHHHHCCCCCHHH	30.01	28348404
642	Phosphorylation	SIMSENRSREELGKV HHHCCCCCHHHHHCC	56.47	28348404
658	Phosphorylation	SQSSFSGSMEIIEVS CCCCCCCCCEEEEEC	16.43	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
446	S	Phosphorylation	Kinase	MK01	P28482	PhosphoELM

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
55	K	Acetylation	22547814
(Microbial infection) Acetylated at Lys-55 by the M.tuberculosis Eis protein; this leads to the inhibition of JNK-dependent autophagy, phagosome maturation, and ROS (reactive oxygen species) generation for enhanced intracellular survival of M.tuberculosis.
446	S	Phosphorylation	12794087
Phosphorylated at Ser-446 by MAPK1/ERK2, which prevents its degradation, and thereby stabilizes it and blocks JNK MAPK activity.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DUS16_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MK14_HUMAN	MAPK14	physical	11359773
MK09_HUMAN	MAPK9	physical	11359773
MK10_HUMAN	MAPK10	physical	11359773
MK01_HUMAN	MAPK1	physical	11489891
MK08_HUMAN	MAPK8	physical	11489891
MK14_HUMAN	MAPK14	physical	11489891
MK14_HUMAN	MAPK14	physical	27880917
MK09_HUMAN	MAPK9	physical	27880917
DUS16_HUMAN	DUSP16	physical	27432908
MLF1_HUMAN	MLF1	physical	27432908
TEBP_HUMAN	PTGES3	physical	27432908
MK09_HUMAN	MAPK9	physical	27432908
NXF2_HUMAN	NXF2	physical	27432908
MK08_HUMAN	MAPK8	physical	27432908
AIP_HUMAN	AIP	physical	27432908
KCD20_HUMAN	KCTD20	physical	27432908
1433B_HUMAN	YWHAB	physical	27432908
HSPB1_HUMAN	HSPB1	physical	27432908
HIG1A_HUMAN	HIGD1A	physical	27432908
MK14_HUMAN	MAPK14	physical	27432908
ARF5_HUMAN	ARF5	physical	27432908
DNJB1_HUMAN	DNAJB1	physical	27432908
PFD3_HUMAN	VBP1	physical	27432908

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DUS16_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-501, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Activation of ERK induces phosphorylation of MAPK phosphatase-7, aJNK specific phosphatase, at Ser-446."; Masuda K., Shima H., Katagiri C., Kikuchi K.; J. Biol. Chem. 278:32448-32456(2003). Cited for: PHOSPHORYLATION AT SER-446.	12794087 [Abstract]

show

show