NXF2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NXF2_HUMAN
• UniProt AC: Q9GZY0
• Protein Name: Nuclear RNA export factor 2
• Gene Name: NXF2
• Organism: Homo sapiens (Human).
• Sequence Length: 626
• Subcellular Localization: Nucleus, nucleoplasm. Cytoplasm. Localized in the nucleoplasm and at the nuclear envelope. Shuttles between the nucleus and the cytoplasm.
• Protein Description: Involved in the export of mRNA from the nucleus to the cytoplasm..
• Protein Sequence: MCSTLKKCGTYRTEVAECHDHGSTFQGRKKGGSSFRDNFDKRSCHYEHGGYERPPSHCQENDGSVEMRDVHKDQQLRHTPYSIRCERRMKWHSEDEIRITTWRNRKPPERKMSQNTQDGYTRNWFKVTIPYGIKYDKAWLMNSIQSHCSDRFTPVDFHYVRNRACFFVQDASAASALKDVSYKIYDDENQKICIFVNHSTAPYSVKNKLKPGQMEMLKLTMNKRYNVSQQALDLQNLRFDPDLMGRDIDIILNRRNCMAATLKIIERNFPELLSLNLCNNKLYQLDGLSDITEKAPKVKTLNLSKNKLESAWELGKVKGLKLEELWLEGNPLCSTFSDQSAYVSAIRDCFPKLLRLDGRELSAPVIVDIDSSETMKPCKENFTGSETLKHLVLQFLQQYYSIYDSGDRQGLLGAYHDEACFSLAIPFDPKDSAPSSLCKYFEDSRNMKTLKDPYLKGELLRRTKRDIVDSLSALPKTQHDLSSILVDVWCQTERMLCFSVNGVFKEVEGQSQGSVLAFTRTFIATPGSSSSLCIVNDELFVRDASPQETQSAFSIPVSTLSSSSEPSLSQEQQEMVQAFSAQSGMKLEWSQKCLQDNEWNYTRAGQAFTMLQTEGKIPAEAFKQIS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	TLKKCGTYRTEVAEC CCCCCCCEEEEEEEE	10.79	26657352
13	Phosphorylation	KKCGTYRTEVAECHD CCCCCEEEEEEEECC	25.13	18452278
33	Phosphorylation	QGRKKGGSSFRDNFD CCCCCCCCCCCCCCC	34.66	29449344
34	Phosphorylation	GRKKGGSSFRDNFDK CCCCCCCCCCCCCCC	27.81	23917254
81	Phosphorylation	QQLRHTPYSIRCERR CCCCCCCCCEEEEHH	20.20	23186163
82	Phosphorylation	QLRHTPYSIRCERRM CCCCCCCCEEEEHHC	12.54	23186163
82	O-linked_Glycosylation	QLRHTPYSIRCERRM CCCCCCCCEEEEHHC	12.54	30379171
90	Methylation	IRCERRMKWHSEDEI EEEEHHCCCCCCCCE	39.69	116253749
113	Phosphorylation	KPPERKMSQNTQDGY CCCCCCCCCCCCCCC	24.26	29083192
116	Phosphorylation	ERKMSQNTQDGYTRN CCCCCCCCCCCCCCC	22.02	29083192
120	Phosphorylation	SQNTQDGYTRNWFKV CCCCCCCCCCCEEEE	15.71	-
185	Phosphorylation	KDVSYKIYDDENQKI HCCEEEEEECCCCEE	17.12	-
203	Phosphorylation	VNHSTAPYSVKNKLK EECCCCCCHHCCCCC	24.51	-
261	Phosphorylation	RRNCMAATLKIIERN CCCHHHHHHHHHHHH	21.03	24719451
274	Phosphorylation	RNFPELLSLNLCNNK HHCHHHHCCCCCCCC	28.03	27461979
283	Phosphorylation	NLCNNKLYQLDGLSD CCCCCCEEECCCCCH	14.51	27461979
289	Phosphorylation	LYQLDGLSDITEKAP EEECCCCCHHHHHCC	32.28	27461979
292	Phosphorylation	LDGLSDITEKAPKVK CCCCCHHHHHCCCCC	36.10	27461979
383	Phosphorylation	KPCKENFTGSETLKH CCCCCCCCCHHHHHH	51.91	-
477	Phosphorylation	SLSALPKTQHDLSSI HHHCCCCCHHCHHHH	29.24	29759185
482	Phosphorylation	PKTQHDLSSILVDVW CCCHHCHHHHHHHHH	22.76	29759185
483	Phosphorylation	KTQHDLSSILVDVWC CCHHCHHHHHHHHHH	27.52	29759185

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NXF2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NXF2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NXF2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NU214_HUMAN	NUP214	physical	11073998
NU153_HUMAN	NUP153	physical	11073998
NUP62_HUMAN	NUP62	physical	11073998
A4_HUMAN	APP	physical	21832049
LUZP4_HUMAN	LUZP4	physical	25662211
MEIOC_HUMAN	C17orf104	physical	28514442
DVL2_HUMAN	DVL2	physical	28514442
GLE1_HUMAN	GLE1	physical	28514442
STOX2_HUMAN	STOX2	physical	28514442
DVL3_HUMAN	DVL3	physical	28514442
ZN106_HUMAN	ZNF106	physical	28514442
F120B_HUMAN	FAM120B	physical	28514442
RGPD8_HUMAN	RGPD8	physical	28514442
NXT2_HUMAN	NXT2	physical	28514442
NXT1_HUMAN	NXT1	physical	28514442
H12_HUMAN	HIST1H1C	physical	28514442
SI1L2_HUMAN	SIPA1L2	physical	28514442
PER1_HUMAN	PER1	physical	28514442
SETD2_HUMAN	SETD2	physical	28514442
KC1E_HUMAN	CSNK1E	physical	28514442
NUFP1_HUMAN	NUFIP1	physical	28514442
CP131_HUMAN	CEP131	physical	28514442
SRSF8_HUMAN	SRSF8	physical	28514442
RGPD5_HUMAN	RGPD5	physical	28514442
PPHLN_HUMAN	PPHLN1	physical	28514442
MTO1_HUMAN	MTO1	physical	28514442
NUPL2_HUMAN	NUPL2	physical	28514442
DYR1A_HUMAN	DYRK1A	physical	28514442
KC1D_HUMAN	CSNK1D	physical	28514442
ASH1L_HUMAN	ASH1L	physical	28514442
ZN445_HUMAN	ZNF445	physical	28514442
TROP_HUMAN	TRO	physical	28514442
RL26L_HUMAN	RPL26L1	physical	28514442
NU214_HUMAN	NUP214	physical	28514442
TTC31_HUMAN	TTC31	physical	28514442
Z324A_HUMAN	ZNF324	physical	28514442
ATX2_HUMAN	ATXN2	physical	28514442
SAV1_HUMAN	SAV1	physical	28514442
ZN865_HUMAN	ZNF865	physical	28514442
FA83H_HUMAN	FAM83H	physical	28514442
NU153_HUMAN	NUP153	physical	28514442
VANG1_HUMAN	VANGL1	physical	28514442
SUGP2_HUMAN	SUGP2	physical	28514442
HERC5_HUMAN	HERC5	physical	28514442
STAU2_HUMAN	STAU2	physical	28514442
MOV10_HUMAN	MOV10	physical	28514442
UIF_HUMAN	FYTTD1	physical	28514442
BORA_HUMAN	BORA	physical	28514442
YTDC2_HUMAN	YTHDC2	physical	28514442
RICTR_HUMAN	RICTOR	physical	28514442
RENT1_HUMAN	UPF1	physical	28514442
YTDC1_HUMAN	YTHDC1	physical	28514442
ZCCHV_HUMAN	ZC3HAV1	physical	28514442
NEPRO_HUMAN	C3orf17	physical	28514442
N42L2_HUMAN	N4BP2L2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.