ZN445_HUMAN - dbPTM
ZN445_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZN445_HUMAN
UniProt AC P59923
Protein Name Zinc finger protein 445
Gene Name ZNF445
Organism Homo sapiens (Human).
Sequence Length 1031
Subcellular Localization Nucleus .
Protein Description May be involved in transcriptional regulation..
Protein Sequence MPPGRWHAAYPAQAQSSRERGRLQTVKKEEEDESYTPVQAARPQTLNRPGQELFRQLFRQLRYHESSGPLETLSRLRELCRWWLRPDVLSKAQILELLVLEQFLSILPGELRVWVQLHNPESGEEAVALLEELQRDLDGTSWRDPGPAQSPDVHWMGTGALRSAQIWSLASPLRSSSALGDHLEPPYEIEARDFLAGQSDTPAAQMPALFPREGCPGDQVTPTRSLTAQLQETMTFKDVEVTFSQDEWGWLDSAQRNLYRDVMLENYRNMASLVGPFTKPALISWLEAREPWGLNMQAAQPKGNPVAAPTGDDLQSKTNKFILNQEPLEEAETLAVSSGCPATSVSEGIGLRESFQQKSRQKDQCENPIQVRVKKEETNFSHRTGKDSEVSGSNSLDLKHVTYLRVSGRKESLKHGCGKHFRMSSHHYDYKKYGKGLRHMIGGFSLHQRIHSGLKGNKKDVCGKDFSLSSHHQRGQSLHTVGVSFKCSDCGRTFSHSSHLAYHQRLHTQEKAFKCRVCGKAFRWSSNCARHEKIHTGVKPYKCDLCEKAFRRLSAYRLHRETHAKKKFLELNQYRAALTYSSGFDHHLGDQSGEKLFDCSQCRKSFHCKSYVLEHQRIHTQEKPYKCTKCRKTFRWRSNFTRHMRLHEEEKFYKQDECREGFRQSPDCSQPQGAPAVEKTFLCQQCGKTFTRKKTLVDHQRIHTGEKPYQCSDCGKDFAYRSAFIVHKKKHAMKRKPEGGPSFSQDTVFQVPQSSHSKEEPYKCSQCGKAFRNHSFLLIHQRVHTGEKPYKCRECGKAFRWSSNLYRHQRIHSLQKQYDCHESEKTPNVEPKILTGEKRFWCQECGKTFTRKRTLLDHKGIHSGEKRYKCNLCGKSYDRNYRLVNHQRIHSTERPFKCQWCGKEFIGRHTLSSHQRKHTRAAQAERSPPARSSSQDTKLRLQKLKPSEEMPLEDCKEACSQSSRLTGLQDISIGKKCHKCSICGKTFNKSSQLISHKRFHTRERPFKCSKCGKTFRWSSNLARHMKNHIRD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
28SumoylationGRLQTVKKEEEDESY
CCCCCCCCHHCCCCC		67.0525114211
35PhosphorylationKEEEDESYTPVQAAR
CHHCCCCCCCCCCCC		17.0227642862
67PhosphorylationQLRYHESSGPLETLS
HHHHHHCCCHHHHHH		41.2524719451
150PhosphorylationRDPGPAQSPDVHWMG
CCCCCCCCCCCEEEC		25.7725850435
168PhosphorylationLRSAQIWSLASPLRS
HCHHHHHHHHCCCCC		18.7123401153
171PhosphorylationAQIWSLASPLRSSSA
HHHHHHHCCCCCCCC		29.7530266825
177PhosphorylationASPLRSSSALGDHLE
HCCCCCCCCCCCCCC		28.8528555341
199PhosphorylationRDFLAGQSDTPAAQM
HHHHCCCCCCCHHHC		42.4021712546
201PhosphorylationFLAGQSDTPAAQMPA
HHCCCCCCCHHHCCC		21.7728555341
221PhosphorylationGCPGDQVTPTRSLTA
CCCCCCCCCCHHHHH		17.20-
237UbiquitinationLQETMTFKDVEVTFS
HHCCEECCEEEEEEE		52.2630230243
267PhosphorylationRDVMLENYRNMASLV
HHHHHHHHHHHHHHH		8.2522210691
272PhosphorylationENYRNMASLVGPFTK
HHHHHHHHHHCCCCH		16.9022210691
317UbiquitinationTGDDLQSKTNKFILN
CCHHHHHHCCCCCCC		43.0629967540
317SumoylationTGDDLQSKTNKFILN
CCHHHHHHCCCCCCC		43.0628112733
320AcetylationDLQSKTNKFILNQEP
HHHHHCCCCCCCCCC		38.7319811673
374SumoylationNPIQVRVKKEETNFS
CCCEEEEECCCCCCC		43.85-
374SumoylationNPIQVRVKKEETNFS
CCCEEEEECCCCCCC		43.8528112733
375SumoylationPIQVRVKKEETNFSH
CCEEEEECCCCCCCC		58.90-
375SumoylationPIQVRVKKEETNFSH
CCEEEEECCCCCCCC		58.9028112733
378PhosphorylationVRVKKEETNFSHRTG
EEEECCCCCCCCCCC		42.5322468782
381PhosphorylationKKEETNFSHRTGKDS
ECCCCCCCCCCCCCC		17.7122468782
384PhosphorylationETNFSHRTGKDSEVS
CCCCCCCCCCCCCCC		43.0622468782
386UbiquitinationNFSHRTGKDSEVSGS
CCCCCCCCCCCCCCC		58.4229967540
399SumoylationGSNSLDLKHVTYLRV
CCCCCCCCEEEEEEE		35.3828112733
399SumoylationGSNSLDLKHVTYLRV
CCCCCCCCEEEEEEE		35.38-
424PhosphorylationCGKHFRMSSHHYDYK
CCCCCCCCCCCCCHH		23.43-
428PhosphorylationFRMSSHHYDYKKYGK
CCCCCCCCCHHHHCH		18.62-
433PhosphorylationHHYDYKKYGKGLRHM
CCCCHHHHCHHHHHH		21.66-
464SumoylationNKKDVCGKDFSLSSH
CCCCCCCCCCCCCCH		50.93-
464SumoylationNKKDVCGKDFSLSSH
CCCCCCCCCCCCCCH		50.93-
554PhosphorylationEKAFRRLSAYRLHRE
HHHHHHHHHHHHHCH		22.80-
567SumoylationRETHAKKKFLELNQY
CHHHHHHHHHHHHHH		55.2528112733
567SumoylationRETHAKKKFLELNQY
CHHHHHHHHHHHHHH		55.25-
574PhosphorylationKFLELNQYRAALTYS
HHHHHHHHHHHHEEC		10.93-
592PhosphorylationDHHLGDQSGEKLFDC
CCCCCCCCCCEEECH		54.3728555341
651SumoylationMRLHEEEKFYKQDEC
CCHHHHHHHHCHHHH		58.22-
651SumoylationMRLHEEEKFYKQDEC
CCHHHHHHHHCHHHH		58.22-
653PhosphorylationLHEEEKFYKQDECRE
HHHHHHHHCHHHHHH		20.8633259812
654SumoylationHEEEKFYKQDECREG
HHHHHHHCHHHHHHC		55.17-
654SumoylationHEEEKFYKQDECREG
HHHHHHHCHHHHHHC		55.1728112733
665PhosphorylationCREGFRQSPDCSQPQ
HHHCHHCCCCCCCCC		20.6023401153
704PhosphorylationVDHQRIHTGEKPYQC
ECCCCCCCCCCCEEC		44.6728111955
720PhosphorylationDCGKDFAYRSAFIVH
CCCCCCCHHHEEHHH		12.70-
736SumoylationKKHAMKRKPEGGPSF
HHHHCCCCCCCCCCC		41.7328112733
742PhosphorylationRKPEGGPSFSQDTVF
CCCCCCCCCCCCCEE		40.5825022875
744PhosphorylationPEGGPSFSQDTVFQV
CCCCCCCCCCCEEEC		31.3325022875
747PhosphorylationGPSFSQDTVFQVPQS
CCCCCCCCEEECCCC		18.6425022875
754PhosphorylationTVFQVPQSSHSKEEP
CEEECCCCCCCCCCC		24.7725022875
755PhosphorylationVFQVPQSSHSKEEPY
EEECCCCCCCCCCCC		26.9125022875
757PhosphorylationQVPQSSHSKEEPYKC
ECCCCCCCCCCCCCC		43.6525022875
758UbiquitinationVPQSSHSKEEPYKCS
CCCCCCCCCCCCCCC		61.7525015289
758SumoylationVPQSSHSKEEPYKCS
CCCCCCCCCCCCCCC		61.7528112733
759UbiquitinationPQSSHSKEEPYKCSQ
CCCCCCCCCCCCCCC		68.1925015289
762PhosphorylationSHSKEEPYKCSQCGK
CCCCCCCCCCCCCCH		28.1025022875
770UbiquitinationKCSQCGKAFRNHSFL
CCCCCCHHHHCCCEE		8.2325015289
771UbiquitinationCSQCGKAFRNHSFLL
CCCCCHHHHCCCEEE		10.2825015289
785PhosphorylationLIHQRVHTGEKPYKC
EEEEEECCCCCCEEC		44.1529496963
788UbiquitinationQRVHTGEKPYKCREC
EEECCCCCCEECCCC		55.80-
788SumoylationQRVHTGEKPYKCREC
EEECCCCCCEECCCC		55.80-
788SumoylationQRVHTGEKPYKCREC
EEECCCCCCEECCCC		55.80-
813PhosphorylationYRHQRIHSLQKQYDC
HHHHHHHHHHHHHCC		30.0821857030
832SumoylationKTPNVEPKILTGEKR
CCCCCCCCCCCCCCE		36.52-
832SumoylationKTPNVEPKILTGEKR
CCCCCCCCCCCCCCE		36.52-
859SumoylationKRTLLDHKGIHSGEK
CCCHHCCCCCCCCCC		60.26-
859SumoylationKRTLLDHKGIHSGEK
CCCHHCCCCCCCCCC		60.26-
863PhosphorylationLDHKGIHSGEKRYKC
HCCCCCCCCCCCEEE		46.88-
891PhosphorylationVNHQRIHSTERPFKC
CCCCCCCCCCCCCCC		29.5928555341
927PhosphorylationRAAQAERSPPARSSS
HHHHHHHCCCCCCCC		27.0924173317
938SumoylationRSSSQDTKLRLQKLK
CCCCHHHHHHHHHCC		39.6428112733
938SumoylationRSSSQDTKLRLQKLK
CCCCHHHHHHHHHCC		39.64-
956SumoylationEMPLEDCKEACSQSS
CCCHHHHHHHHHHCC		61.7528112733
963UbiquitinationKEACSQSSRLTGLQD
HHHHHHCCCCCCCCC		24.5432015554
964UbiquitinationEACSQSSRLTGLQDI
HHHHHCCCCCCCCCC		41.3325015289
972PhosphorylationLTGLQDISIGKKCHK
CCCCCCCCCCCCCCC		33.3126437602
975UbiquitinationLQDISIGKKCHKCSI
CCCCCCCCCCCCCCC		51.0232015554
975SumoylationLQDISIGKKCHKCSI
CCCCCCCCCCCCCCC		51.0228112733
976UbiquitinationQDISIGKKCHKCSIC
CCCCCCCCCCCCCCC		36.0425015289
989SumoylationICGKTFNKSSQLISH
CCCCCCCCHHHHHCC		47.49-
989SumoylationICGKTFNKSSQLISH
CCCCCCCCHHHHHCC		47.49-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ZN445_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ZN445_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZN445_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ZN445_HUMAN !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZN445_HUMAN

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Related Literatures of Post-Translational Modification

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