| UniProt ID | NEPRO_HUMAN | |
|---|---|---|
| UniProt AC | Q6NW34 | |
| Protein Name | Nucleolus and neural progenitor protein {ECO:0000305} | |
| Gene Name | NEPRO {ECO:0000312|HGNC:HGNC:24496} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 567 | |
| Subcellular Localization | Nucleus . Nucleus, nucleolus . | |
| Protein Description | May play a role in cortex development as part of the Notch signaling pathway. Downstream of Notch may repress the expression of proneural genes and inhibit neuronal differentiation thereby maintaining neural progenitors. May also play a role in preimplentation embryo development.. | |
| Protein Sequence | MMAAVPPGLEPWNRVRIPKAGNRSAVTVQNPGAALDLCIAAVIKECHLVILSLKSQTLDAETDVLCAVLYSNHNRMGRHKPHLALKQVEQCLKRLKNMNLEGSIQDLFELFSSNENQPLTTKVCVVPSQPVVELVLMKVLGACKLLLRLLDCCCKTFLLTVKHLGLQEFIILNLVMVGLVSRLWVLYKGVLKRLILLYEPLFGLLQEVARIQPMPYFKDFTFPSDITEFLGQPYFEAFKKKMPIAFAAKGINKLLNKLFLINEQSPRASEETLLGISKKAKQMKINVQNNVDLGQPVKNKRVFKEESSEFDVRAFCNQLKHKATQETSFDFKCSQSRLKTTKYSSQKVIGTPHAKSFVQRFREAESFTQLSEEIQMAVVWCRSKKLKAQAIFLGNKLLKSNRLKHLEAQGTSLPKKLECIKTSICNHLLRGSGIKTSKHHLRQRRSQNKFLRRQRKPQRKLQSTLLREIQQFSQGTRKSATDTSAKWRLSHCTVHRTDLYPNSKQLLNSGVSMPVIQTKEKMIHENLRGIHENETDSWTVMQINKNSTSGTIKETDDIDDIFALMGV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 52 | Phosphorylation | ECHLVILSLKSQTLD HCCCHHEECCCCCCC | 24719451 | ||
| 187 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 198 | Phosphorylation | LKRLILLYEPLFGLL HHHHHHHHHHHHHHH | - | ||
| 216 | Phosphorylation | ARIQPMPYFKDFTFP HHHCCCCCCCCCCCC | - | ||
| 228 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 253 | Ubiquitination | FAAKGINKLLNKLFL HHHHHHHHHHHHHHC | - | ||
| 257 | Ubiquitination | GINKLLNKLFLINEQ HHHHHHHHHHCCCCC | 21890473 | ||
| 257 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 265 | Phosphorylation | LFLINEQSPRASEET HHCCCCCCCCCCHHH | 29255136 | ||
| 269 | Phosphorylation | NEQSPRASEETLLGI CCCCCCCCHHHHHHH | 22199227 | ||
| 272 | Phosphorylation | SPRASEETLLGISKK CCCCCHHHHHHHHHH | 22199227 | ||
| 298 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 298 | Ubiquitination | VDLGQPVKNKRVFKE CCCCCCCCCCCCCCC | 2190698 | ||
| 300 | Ubiquitination | LGQPVKNKRVFKEES CCCCCCCCCCCCCCC | - | ||
| 304 | Ubiquitination | VKNKRVFKEESSEFD CCCCCCCCCCCCHHH | - | ||
| 307 | Phosphorylation | KRVFKEESSEFDVRA CCCCCCCCCHHHHHH | 28555341 | ||
| 320 | Methylation | RAFCNQLKHKATQET HHHHHHHCCCCCCCC | 115966373 | ||
| 320 | Ubiquitination | RAFCNQLKHKATQET HHHHHHHCCCCCCCC | - | ||
| 324 | Phosphorylation | NQLKHKATQETSFDF HHHCCCCCCCCCCCC | 23312004 | ||
| 327 | Phosphorylation | KHKATQETSFDFKCS CCCCCCCCCCCCCCC | 25850435 | ||
| 328 | Phosphorylation | HKATQETSFDFKCSQ CCCCCCCCCCCCCCH | 23401153 | ||
| 332 | Methylation | QETSFDFKCSQSRLK CCCCCCCCCCHHHCC | 115966379 | ||
| 347 | Acetylation | TTKYSSQKVIGTPHA CCCCCCCCCCCCHHH | 26051181 | ||
| 351 | Phosphorylation | SSQKVIGTPHAKSFV CCCCCCCCHHHHHHH | 24719451 | ||
| 368 | Phosphorylation | FREAESFTQLSEEIQ HHHHHHHHHHHHHHH | - | ||
| 404 | Ubiquitination | LLKSNRLKHLEAQGT HHHHCCCHHHHHCCC | - | ||
| 411 | Phosphorylation | KHLEAQGTSLPKKLE HHHHHCCCCCCHHHH | - | ||
| 412 | Phosphorylation | HLEAQGTSLPKKLEC HHHHCCCCCCHHHHH | 24719451 | ||
| 415 | Ubiquitination | AQGTSLPKKLECIKT HCCCCCCHHHHHHHH | - | ||
| 421 | Ubiquitination | PKKLECIKTSICNHL CHHHHHHHHHHHHHH | - | ||
| 473 | Phosphorylation | LREIQQFSQGTRKSA HHHHHHHCCCCCCCC | 21406692 | ||
| 476 | Phosphorylation | IQQFSQGTRKSATDT HHHHCCCCCCCCCCC | 21406692 | ||
| 486 | Acetylation | SATDTSAKWRLSHCT CCCCCCCCHHHHCCC | 26051181 | ||
| 512 | Phosphorylation | QLLNSGVSMPVIQTK HHHHCCCCCCCCCCH | 28122231 | ||
| 518 | Phosphorylation | VSMPVIQTKEKMIHE CCCCCCCCHHHHHHH | 28122231 | ||
| 521 | Ubiquitination | PVIQTKEKMIHENLR CCCCCHHHHHHHHHC | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NEPRO_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NEPRO_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NEPRO_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| NEPRO_HUMAN | C3orf17 | physical | 26472760 | |
| POP1_HUMAN | POP1 | physical | 26472760 | |
| UBE2O_HUMAN | UBE2O | physical | 26472760 | |
| NPM_HUMAN | NPM1 | physical | 26472760 | |
| RPP38_HUMAN | RPP38 | physical | 26472760 | |
| RLA2_HUMAN | RPLP2 | physical | 26472760 | |
| RP25L_HUMAN | RPP25L | physical | 26472760 | |
| EMD_HUMAN | EMD | physical | 26472760 | |
| H12_HUMAN | HIST1H1C | physical | 26472760 | |
| YBOX1_HUMAN | YBX1 | physical | 26472760 | |
| POP7_HUMAN | POP7 | physical | 26472760 | |
| PPM1G_HUMAN | PPM1G | physical | 26472760 | |
| NP1L1_HUMAN | NAP1L1 | physical | 26472760 | |
| AT1A1_HUMAN | ATP1A1 | physical | 26472760 | |
| LDHB_HUMAN | LDHB | physical | 26472760 | |
| RL27A_HUMAN | RPL27A | physical | 26472760 | |
| AT2A2_HUMAN | ATP2A2 | physical | 26472760 | |
| RL13_HUMAN | RPL13 | physical | 26472760 | |
| RPP30_HUMAN | RPP30 | physical | 26472760 | |
| RL28_HUMAN | RPL28 | physical | 26472760 | |
| RPP14_HUMAN | RPP14 | physical | 26472758 | |
| RPP29_HUMAN | POP4 | physical | 26472758 | |
| RPP40_HUMAN | RPP40 | physical | 26472758 | |
| RPP30_HUMAN | RPP30 | physical | 26472758 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
