| UniProt ID | MEIOC_HUMAN | |
|---|---|---|
| UniProt AC | A2RUB1 | |
| Protein Name | Meiosis-specific coiled-coil domain-containing protein MEIOC {ECO:0000305} | |
| Gene Name | MEIOC {ECO:0000312|HGNC:HGNC:26670} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 952 | |
| Subcellular Localization | Cytoplasm . Nucleus . at late pachytene a fraction is nuclear. | |
| Protein Description | Is required for meiosis completion in both male and female germ cells. Confers stability to numerous meiotic mRNAs in gonads allowing proper initiation and progression into meiosis prophase I. The function may involve YTHDC2 and is independent of induction by retinoic acid (RA). Maintains an extended meiotic prophase I by properly promoting the transition from a mitotic to a meiotic cell cycle program by binding transcripts through its interaction with YTHDC2 that regulate the mitotic cell cycle.. | |
| Protein Sequence | MEVRRGDTCPRPHPSGLREEGLEPKVAFPGGANRCWNLGADAGSRLTDVFGSVMLTGSASFYDCYTSQSEDNVDLRQTYTPFSSTEYSSSVDSSLFCAPWSTYGDDIKQPSNSQISIKNRIQTERNDYGSETDLYGLVSNILEEQDKSQPYFAEGTCSSNLKSVWPMNTSRFADHHDLLTETKRPIDTVISQQAFYSDESVSAMEKQYLRNSNLTPQQKIDELHHGFTGLDLEEQWMYPSRSDHSNCHNIQTNDTAKTTFQEYPLIKNCFTPQTGLSDIMKESGVDIYHYGRDRICTKGLEAPLQQKRAEMFLSQFNRYNENVDYCRYPEYVHPNKAKLNKCSNFSVQDSKKLANGTPETPTVEADTYTKLFQVKPANQKKMEETIPDQQNFTFPKTTPHLTEKQFAKEAVFTADFGLTSEYGLKPHTACPANDFANVTEKQQFAKPDPPHSEYFKSVNLLSNSATSSGGINLNRPTWMNVQTKNNTPIPYRNQGNLMKLNSHLSAASKGSNHSSDFPQLSSTNLTPNSNLFQKYCQENPSAFSSFDFSYSGAERIQSVNHIEGLTKPGEENLFKLVTDKKIKQPNGFCDNYSAQKYGIIENVNKHNFQAKPQSGHYDPEEGPKHLDGLSQNTYQDLLESQGHSNSHRTRGGDNSRVNRTQVSCFSNNYMMGDLRHNQCFQQLGSNGFPLRSTHPFGHSVVPLLDSYDLLSYDDLSHLYPYFNMMYGDNSFSGLMPTFGFQRPIKTRSGPASELHIRLEECCEQWRALEKERKKTELALAKNYPGKKVSSTNNTPVPRLTSNPSRVDRLIVDELRELARVVTLLGKMERLRSSLLHASISTALDRHLESIHIVQSRRKDEIVNASNRQRQGVPRCQDDRDVFALASAIKEMCVATRKTRTALWCALQMTLPKTASTADVVKPLQDTVNCEDKVHESINSSNPMNQRGETNKH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 123 | Phosphorylation | SIKNRIQTERNDYGS EEECCHHHCCCCCCC | 28450419 | ||
| 128 | Phosphorylation | IQTERNDYGSETDLY HHHCCCCCCCHHHHH | 28450419 | ||
| 130 | Phosphorylation | TERNDYGSETDLYGL HCCCCCCCHHHHHHH | 28450419 | ||
| 132 | Phosphorylation | RNDYGSETDLYGLVS CCCCCCHHHHHHHHH | 28450419 | ||
| 135 | Phosphorylation | YGSETDLYGLVSNIL CCCHHHHHHHHHHHH | 28450419 | ||
| 158 | Phosphorylation | YFAEGTCSSNLKSVW CCCCCCCCCCCCCCC | 22210691 | ||
| 163 | Phosphorylation | TCSSNLKSVWPMNTS CCCCCCCCCCCCCHH | 22210691 | ||
| 169 | Phosphorylation | KSVWPMNTSRFADHH CCCCCCCHHHCCCCH | - | ||
| 170 | Phosphorylation | SVWPMNTSRFADHHD CCCCCCHHHCCCCHH | - | ||
| 271 | Phosphorylation | PLIKNCFTPQTGLSD CCCCCCCCCCCCHHH | - | ||
| 283 | Phosphorylation | LSDIMKESGVDIYHY HHHHHHHHCCCEEEE | 23607784 | ||
| 288 | Phosphorylation | KESGVDIYHYGRDRI HHHCCCEEEECCCCC | 23607784 | ||
| 290 | Phosphorylation | SGVDIYHYGRDRICT HCCCEEEECCCCCCC | 23607784 | ||
| 385 | Phosphorylation | NQKKMEETIPDQQNF CCCHHHHCCCCCCCC | - | ||
| 393 | Phosphorylation | IPDQQNFTFPKTTPH CCCCCCCCCCCCCCC | - | ||
| 502 | Phosphorylation | GNLMKLNSHLSAASK CCHHHHHHHHHHHHC | 28348404 | ||
| 505 | Phosphorylation | MKLNSHLSAASKGSN HHHHHHHHHHHCCCC | 28348404 | ||
| 508 | Phosphorylation | NSHLSAASKGSNHSS HHHHHHHHCCCCCCC | 27251275 | ||
| 655 | Phosphorylation | RTRGGDNSRVNRTQV CCCCCCCCCCCCCEE | 23403867 | ||
| 783 | Phosphorylation | ELALAKNYPGKKVSS HHHHHHHCCCCCCCC | - | ||
| 791 | Phosphorylation | PGKKVSSTNNTPVPR CCCCCCCCCCCCCCC | 23532336 | ||
| 801 | Phosphorylation | TPVPRLTSNPSRVDR CCCCCCCCCHHHHHH | 29759185 | ||
| 804 | Phosphorylation | PRLTSNPSRVDRLIV CCCCCCHHHHHHHHH | 29759185 | ||
| 822 | Phosphorylation | RELARVVTLLGKMER HHHHHHHHHHHHHHH | - | ||
| 865 | Phosphorylation | KDEIVNASNRQRQGV HHHHHCCCHHHCCCC | 30242111 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MEIOC_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MEIOC_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MEIOC_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of MEIOC_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
