KCD20_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCD20_HUMAN
• UniProt AC: Q7Z5Y7
• Protein Name: BTB/POZ domain-containing protein KCTD20
• Gene Name: KCTD20
• Organism: Homo sapiens (Human).
• Sequence Length: 419
• Subcellular Localization: Cytoplasm . Colocalizes with BTBD10 in filamentous structures.
• Protein Description: Promotes the phosphorylation of AKT family members..
• Protein Sequence: MNVHRGSDSDRLLRQEASCLVDDTLAVAQEKEANSLASSGPHNLTYPLGPRNEDLSLDYASQPANLQFPHIMPLAEDIKGSCFQSGNKRNHEPFIAPERFGNSSVGFGSNSHSQAPEKVTLLVDGTRFVVNPQIFTAHPDTMLGRMFGPGREYNFTRPNEKGEYEIAEGISATVFRTVLDYYKTGIINCPDGISIPDLRDTCDYLCINFDFNTIRCQDLSALLHELSNDGAHKQFDHYLEELILPIMVGCAKKGERECHIVVLTDEDSVDWDEDHPPPMGEEYSQILYSSKLYRFFKYIENRDVAKTVLKERGLKNIRIGIEGYPTCKEKIKRRPGGRSEVIYNYVQRPFIQMSWEKEEGKSRHVDFQCVRSKSLTNLVAAGDDVLEDQEILMHHPPQVDELDRLNAPLSQMASNDFQD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MNVHRGSDSDRLLR -CCCCCCCHHHHHHH	33.62	25159151
9	Phosphorylation	NVHRGSDSDRLLRQE CCCCCCHHHHHHHHH	26.74	28348404
16	Ubiquitination	SDRLLRQEASCLVDD HHHHHHHHHHHHHHC	35.80	-
16	Ubiquitination	SDRLLRQEASCLVDD HHHHHHHHHHHHHHC	35.80	21963094
31	Ubiquitination	TLAVAQEKEANSLAS HHHHHHHHHHHHHHH	50.47	29967540
35	Phosphorylation	AQEKEANSLASSGPH HHHHHHHHHHHCCCC	32.15	28555341
38	Ubiquitination	KEANSLASSGPHNLT HHHHHHHHCCCCCCC	40.91	-
56	Phosphorylation	GPRNEDLSLDYASQP CCCCCCCCCCCCCCC	31.36	27251275
59	Phosphorylation	NEDLSLDYASQPANL CCCCCCCCCCCCCCC	17.28	27642862
88	Ubiquitination	SCFQSGNKRNHEPFI CCCCCCCCCCCCCCC	59.09	27667366
109	Phosphorylation	NSSVGFGSNSHSQAP CCCCCCCCCCCCCCC	32.66	20068231
111	Phosphorylation	SVGFGSNSHSQAPEK CCCCCCCCCCCCCCE	26.64	28555341
118 (in isoform 1)	Ubiquitination	-	39.19	21890473
118	Ubiquitination	SHSQAPEKVTLLVDG CCCCCCCEEEEEECC	39.19	21890473
118	Ubiquitination	SHSQAPEKVTLLVDG CCCCCCCEEEEEECC	39.19	23000965
140	Ubiquitination	QIFTAHPDTMLGRMF CCEECCCCCHHHHCC	34.58	29967540
153	Phosphorylation	MFGPGREYNFTRPNE CCCCCCCCCCCCCCC	17.76	27642862
161	Ubiquitination	NFTRPNEKGEYEIAE CCCCCCCCCCEEECC	64.78	21963094
162	Ubiquitination	FTRPNEKGEYEIAEG CCCCCCCCCEEECCC	36.22	29967540
183	Ubiquitination	RTVLDYYKTGIINCP HHHHHHHHHCCEECC	33.76	29967540
284	Phosphorylation	PPMGEEYSQILYSSK CCCCHHHHHHHHHHH	17.64	22468782
288	Phosphorylation	EEYSQILYSSKLYRF HHHHHHHHHHHHHHH	16.72	22468782
289	Phosphorylation	EYSQILYSSKLYRFF HHHHHHHHHHHHHHH	19.97	22468782
297	Ubiquitination	SKLYRFFKYIENRDV HHHHHHHHHHHCCHH	42.48	-
298	Phosphorylation	KLYRFFKYIENRDVA HHHHHHHHHHCCHHH	14.33	29978859
306	Ubiquitination	IENRDVAKTVLKERG HHCCHHHHHHHHHCC	38.73	29967540
307	Phosphorylation	ENRDVAKTVLKERGL HCCHHHHHHHHHCCC	22.72	29978859
328	Ubiquitination	IEGYPTCKEKIKRRP ECCCCCHHHHHHCCC	65.60	29967540
357	Ubiquitination	FIQMSWEKEEGKSRH EEECEEECCCCCCCC	55.60	-
372	Phosphorylation	VDFQCVRSKSLTNLV CCEEEEECHHHHHHH	13.24	26074081
374	Phosphorylation	FQCVRSKSLTNLVAA EEEEECHHHHHHHHC	41.49	25159151
376	Phosphorylation	CVRSKSLTNLVAAGD EEECHHHHHHHHCCC	33.33	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KCD20_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCD20_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCD20_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of KCD20_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.