APLD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: APLD1_HUMAN
• UniProt AC: Q96LR9
• Protein Name: Apolipoprotein L domain-containing protein 1
• Gene Name: APOLD1
• Organism: Homo sapiens (Human).
• Sequence Length: 279
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: May be involved in angiogenesis. May play a role in activity-dependent changes of brain vasculature. May affect blood-brain permeability..
• Protein Sequence: MFRAPCHRLRARGTRKARAGAWRGCTFPCLGKGMERPAAREPHGPDALRRFQGLLLDRRGRLHGQVLRLREVARRLERLRRRSLVANVAGSSLSATGALAAIVGLSLSPVTLGTSLLVSAVGLGVATAGGAVTITSDLSLIFCNSRELRRVQEIAATCQDQMREILSCLEFFCRWQGCGDRQLLQCGRNASIALYNSVYFIVFFGSRGFLIPRRAEGDTKVSQAVLKAKIQKLAESLESCTGALDELSEQLESRVQLCTKSSRGHDLKISADQRAGLFF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
133	O-linked_Glycosylation	ATAGGAVTITSDLSL CCCCCEEEECCCCEE	20.29	OGP
135	O-linked_Glycosylation	AGGAVTITSDLSLIF CCCEEEECCCCEEEE	13.56	OGP
136	O-linked_Glycosylation	GGAVTITSDLSLIFC CCEEEECCCCEEEEE	32.48	OGP
260	Ubiquitination	SRVQLCTKSSRGHDL HHHHHHHHCCCCCCC	45.50	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of APLD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of APLD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of APLD1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of APLD1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.