F193B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: F193B_HUMAN
• UniProt AC: Q96PV7
• Protein Name: Protein FAM193B
• Gene Name: FAM193B
• Organism: Homo sapiens (Human).
• Sequence Length: 902
• Subcellular Localization: Cytoplasm . Nucleus . Partly colocalized with an endoplasmic reticulum marker, HSP90B1. Shuttles between nucleus and cytoplasm.
• Protein Sequence: MTRRRSRPSGGAGRRERARAAGPQKPQAPEPPPPPSLEAGAGAGPPEAPAEPDHDGPREDDEPNLVPGPQVPPASSQPVQTCCLLCHRERKGWEEGPSQNGLVLQGEKLPPDFMPKLVKNLLGEMPLWVCQSCRKSMEEDERQTGREHAVAISLSHTSCKSQSCGDDSHSSSSSSSSSSSSSSSSCPGNSGDWDPSSFLSAHKLSGLWNSPHSSGAMPGSSLGSPPTIPGEAFPVSEHHQHSDLTAPPNSPTGHHPQPASLIPSHPSSFGSPPHPHLLPTTPAAPFPAQASECPVAAATAPHTPGPCQSSHLPSTSMPLLKMPPPFSGCSHPCSGHCGGHCSGPLLPPPSSQPLPSTHRDPGCKGHKFAHSGLACQLPQPCEADEGLGEEEDSSSERSSCTSSSTHQRDGKFCDCCYCEFFGHNAPPAAPTSRNYTEIREKLRSRLTRRKEELPMKGGTLGGIPGEPAVDHRDVDELLEFINSTEPKVPNSARAAKRARHKLKKKEKEKAQLAAEALKQANRVSGSREPRPARERLLEWPDRELDRVNSFLSSRLQEIKNTVKDSIRASFSVCELSMDSNGFSKEGAAEPEPQSLPPSNLSGSSEQQPDINLDLSPLTLGSPQNHTLQAPGEPAPPWAEMRGPHPPWTEVRGPPPGIVPENGLVRRLNTVPNLSRVIWVKTPKPGYPSSEEPSSKEVPSCKQELPEPVSSGGKPQKGKRQGSQAKKSEASPAPRPPASLEVPSAKGQVAGPKQPGRVLELPKVGSCAEAGEGSRGSRPGPGWAGSPKTEKEKGSSWRNWPGEAKARPQEQESVQPSGPARPQSLPQGKGRSRRSRNKQEKPASSLDDVFLPKDMDGVEMDETDREVEYFKRFCLDSAKQTRQKVAVNWTNFSLKKTTPSTAQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MTRRRSRPSGGAG --CCCCCCCCCCCCC	46.89	-
9	Phosphorylation	TRRRSRPSGGAGRRE CCCCCCCCCCCCHHH	49.07	23532336
172	Phosphorylation	GDDSHSSSSSSSSSS CCCCCCCCCCCCCCC	36.94	-
173	Phosphorylation	DDSHSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
174	Phosphorylation	DSHSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
175	Phosphorylation	SHSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
176	Phosphorylation	HSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
177	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
178	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
179	Phosphorylation	SSSSSSSSSSSSSSC CCCCCCCCCCCCCCC	35.87	-
196	Phosphorylation	NSGDWDPSSFLSAHK CCCCCCHHHHHHHHH	31.11	-
197	Phosphorylation	SGDWDPSSFLSAHKL CCCCCHHHHHHHHHH	35.28	-
393	Phosphorylation	GLGEEEDSSSERSSC CCCCCCCCCCCCCCC	38.76	26471730
394	Phosphorylation	LGEEEDSSSERSSCT CCCCCCCCCCCCCCC	48.84	28985074
395	Phosphorylation	GEEEDSSSERSSCTS CCCCCCCCCCCCCCC	40.77	30576142
399	Phosphorylation	DSSSERSSCTSSSTH CCCCCCCCCCCCCCC	27.86	30576142
401	Phosphorylation	SSERSSCTSSSTHQR CCCCCCCCCCCCCCC	33.32	30576142
405	Phosphorylation	SSCTSSSTHQRDGKF CCCCCCCCCCCCCCC	24.79	30576142
411	Acetylation	STHQRDGKFCDCCYC CCCCCCCCCCCCCEE	47.29	25953088
549	Phosphorylation	RELDRVNSFLSSRLQ HHHHHHHHHHHHHHH	25.38	23401153
552	Phosphorylation	DRVNSFLSSRLQEIK HHHHHHHHHHHHHHH	16.05	26074081
553	Phosphorylation	RVNSFLSSRLQEIKN HHHHHHHHHHHHHHH	38.87	26074081
561	Phosphorylation	RLQEIKNTVKDSIRA HHHHHHHHHHHHHHH	24.75	23403867
565	Phosphorylation	IKNTVKDSIRASFSV HHHHHHHHHHHHEEE	14.30	23403867
569	Phosphorylation	VKDSIRASFSVCELS HHHHHHHHEEEEEEE	14.27	28348404
571	Phosphorylation	DSIRASFSVCELSMD HHHHHHEEEEEEEEC	24.30	28348404
651	Methylation	HPPWTEVRGPPPGIV CCCCCCCCCCCCCCC	45.74	-
669	Phosphorylation	GLVRRLNTVPNLSRV CCEECCCCCCCCCEE	41.76	19664994
674	Phosphorylation	LNTVPNLSRVIWVKT CCCCCCCCEEEEEEC	31.01	22210691
680	Ubiquitination	LSRVIWVKTPKPGYP CCEEEEEECCCCCCC	44.08	-
681	Phosphorylation	SRVIWVKTPKPGYPS CEEEEEECCCCCCCC	27.25	28555341
701	Acetylation	SKEVPSCKQELPEPV CCCCCCCCCCCCCCC	51.66	11792111
709	Phosphorylation	QELPEPVSSGGKPQK CCCCCCCCCCCCCCC	33.70	25159151
710	Phosphorylation	ELPEPVSSGGKPQKG CCCCCCCCCCCCCCC	52.37	25159151
716	Acetylation	SSGGKPQKGKRQGSQ CCCCCCCCCCCCCCC	74.95	11792121
722	Phosphorylation	QKGKRQGSQAKKSEA CCCCCCCCCCCCCCC	20.73	-
726	Acetylation	RQGSQAKKSEASPAP CCCCCCCCCCCCCCC	57.45	12437889
727	Phosphorylation	QGSQAKKSEASPAPR CCCCCCCCCCCCCCC	37.37	28985074
730	Phosphorylation	QAKKSEASPAPRPPA CCCCCCCCCCCCCCC	19.97	25159151
738	Phosphorylation	PAPRPPASLEVPSAK CCCCCCCCCCCCCCC	30.73	26074081
773	Phosphorylation	CAEAGEGSRGSRPGP CCCCCCCCCCCCCCC	29.21	-
785	Phosphorylation	PGPGWAGSPKTEKEK CCCCCCCCCCCCCCC	18.57	19664994
843	Phosphorylation	NKQEKPASSLDDVFL CCCCCCCCCCCCCCC	39.70	26074081
844	Phosphorylation	KQEKPASSLDDVFLP CCCCCCCCCCCCCCC	37.61	27050516
878	Ubiquitination	RFCLDSAKQTRQKVA HHHHHHHHHHHHHHE	57.04	-
889	Phosphorylation	QKVAVNWTNFSLKKT HHHEEECCCCCCCCC	22.60	23186163
892	Phosphorylation	AVNWTNFSLKKTTPS EEECCCCCCCCCCCC	41.15	14702039

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of F193B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of F193B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of F193B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KCTD5_HUMAN	KCTD5	physical	26188516
CUL3_HUMAN	CUL3	physical	26188516

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.