| UniProt ID | CDKN3_HUMAN | |
|---|---|---|
| UniProt AC | Q16667 | |
| Protein Name | Cyclin-dependent kinase inhibitor 3 | |
| Gene Name | CDKN3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 212 | |
| Subcellular Localization | Cytoplasm, perinuclear region . | |
| Protein Description | May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner.. | |
| Protein Sequence | MKPPSSIQTSEFDSSDEEPIEDEQTPIHISWLSLSRVNCSQFLGLCALPGCKFKDVRRNVQKDTEELKSCGIQDIFVFCTRGELSKYRVPNLLDLYQQCGIITHHHPIADGGTPDIASCCEIMEELTTCLKNYRKTLIHCYGGLGRSCLVAACLLLYLSDTISPEQAIDSLRDLRGSGAIQTIKQYNYLHEFRDKLAAHLSSRDSQSRSVSR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Phosphorylation | ---MKPPSSIQTSEF ---CCCCCCCCCCCC | 48.91 | 19060867 | |
| 5 (in isoform 2) | Phosphorylation | - | 48.91 | - | |
| 6 | Phosphorylation | --MKPPSSIQTSEFD --CCCCCCCCCCCCC | 25.21 | 19060867 | |
| 9 | Phosphorylation | KPPSSIQTSEFDSSD CCCCCCCCCCCCCCC | 28.67 | 29116813 | |
| 10 | Phosphorylation | PPSSIQTSEFDSSDE CCCCCCCCCCCCCCC | 21.64 | 22496350 | |
| 14 | Phosphorylation | IQTSEFDSSDEEPIE CCCCCCCCCCCCCCC | 45.04 | 29116813 | |
| 15 | Phosphorylation | QTSEFDSSDEEPIED CCCCCCCCCCCCCCC | 51.38 | 29116813 | |
| 25 | Phosphorylation | EPIEDEQTPIHISWL CCCCCCCCCCEEEEH | 23.35 | 25841592 | |
| 30 | Phosphorylation | EQTPIHISWLSLSRV CCCCCEEEEHHCCCC | 14.06 | 25841592 | |
| 33 | Phosphorylation | PIHISWLSLSRVNCS CCEEEEHHCCCCCHH | 20.31 | 24719451 | |
| 35 | Phosphorylation | HISWLSLSRVNCSQF EEEEHHCCCCCHHHH | 30.70 | 17081983 | |
| 46 (in isoform 2) | Ubiquitination | - | 3.29 | 21890473 | |
| 52 | Ubiquitination | LCALPGCKFKDVRRN HHCCCCCCHHHHHHH | 62.45 | - | |
| 54 | Ubiquitination | ALPGCKFKDVRRNVQ CCCCCCHHHHHHHHH | 40.59 | - | |
| 62 | Ubiquitination | DVRRNVQKDTEELKS HHHHHHHHCHHHHHH | 63.44 | - | |
| 68 | Sumoylation | QKDTEELKSCGIQDI HHCHHHHHHCCCCEE | 47.16 | - | |
| 69 | Phosphorylation | KDTEELKSCGIQDIF HCHHHHHHCCCCEEE | 30.15 | 25841592 | |
| 80 | Phosphorylation | QDIFVFCTRGELSKY CEEEEEEECCHHHHC | 30.19 | 25841592 | |
| 86 | Ubiquitination | CTRGELSKYRVPNLL EECCHHHHCCCCCHH | 50.10 | 21890473 | |
| 86 (in isoform 1) | Ubiquitination | - | 50.10 | 21890473 | |
| 135 | Ubiquitination | TCLKNYRKTLIHCYG HHHHHHHHHHHHHCC | 37.00 | - | |
| 144 (in isoform 2) | Ubiquitination | - | 4.47 | 21890473 | |
| 184 | Ubiquitination | SGAIQTIKQYNYLHE CCHHHHHHHHCCHHH | 50.55 | 21890473 | |
| 184 (in isoform 1) | Ubiquitination | - | 50.55 | 21890473 | |
| 195 | Ubiquitination | YLHEFRDKLAAHLSS CHHHHHHHHHHHHHC | 35.45 | - | |
| 201 | Phosphorylation | DKLAAHLSSRDSQSR HHHHHHHHCCHHHCC | 17.29 | 28555341 | |
| 209 | Phosphorylation | SRDSQSRSVSR---- CCHHHCCCCCC---- | 29.68 | 26074081 | |
| 211 | Phosphorylation | DSQSRSVSR------ HHHCCCCCC------ | 33.25 | 26074081 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CDKN3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CDKN3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CDKN3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CDK2_HUMAN | CDK2 | physical | 12745075 | |
| CDK2_HUMAN | CDK2 | physical | 8127873 | |
| MS4A3_HUMAN | MS4A3 | physical | 11781350 | |
| CDK1_HUMAN | CDK1 | physical | 8242750 | |
| CDK2_HUMAN | CDK2 | physical | 15530371 | |
| ROCK2_HUMAN | ROCK2 | physical | 24704824 | |
| ROCK1_HUMAN | ROCK1 | physical | 24704824 | |
| MRCKB_HUMAN | CDC42BPB | physical | 24704824 | |
| MYPT1_HUMAN | PPP1R12A | physical | 24704824 | |
| CDKN3_HUMAN | CDKN3 | physical | 27432908 | |
| RD23B_HUMAN | RAD23B | physical | 27432908 | |
| CLPB_HUMAN | CLPB | physical | 27432908 | |
| GOPC_HUMAN | GOPC | physical | 27432908 | |
| RD23A_HUMAN | RAD23A | physical | 27432908 | |
| HAX1_HUMAN | HAX1 | physical | 27432908 | |
| BAG6_HUMAN | BAG6 | physical | 27432908 | |
| ARG28_HUMAN | ARHGEF28 | physical | 27432908 | |
| HDHD5_HUMAN | CECR5 | physical | 27432908 | |
| ODP2_HUMAN | DLAT | physical | 27432908 | |
| NP1L4_HUMAN | NAP1L4 | physical | 27432908 | |
| DI3L1_HUMAN | DIS3L | physical | 27432908 | |
| SEC63_HUMAN | SEC63 | physical | 27432908 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 114550 | Hepatocellular carcinoma (HCC) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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