PRCA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRCA1_HUMAN
• UniProt AC: Q8NCQ7
• Protein Name: Protein PROCA1 {ECO:0000305}
• Gene Name: PROCA1
• Organism: Homo sapiens (Human).
• Sequence Length: 364
• Protein Sequence: MWVRTTLTIERWTKEKTEPKARSWDEALSDVNRLPSWERGHLLAGVASSTDVSTFSEGGDCKEPDKCCWRHKQCTGHIIYPFASDCVRHSLHLHSVNHCNCNSRLKDSSEDSSSSRGAGPTCSHVIESPCFELTPEEEHVERFRYGWCKSYRPVSVAVIHHPLYHECGADDLNEEEEEEEEESKPPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSESPTGKGQGSKVIKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSPPDVSRSLSARQLARMSESSPESREELESEDSYNGRGQGELSSEDIVESSSPRKRENTVQAKKTGAKPSQARKVNKRKSPPGSNPNLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4 (in isoform 3)	Phosphorylation	-	13.38	29507054
5	Phosphorylation	---MWVRTTLTIERW ---CCCEEEEEEEHH	19.28	29759185
6	Phosphorylation	--MWVRTTLTIERWT --CCCEEEEEEEHHH	16.02	29759185
8	Phosphorylation	MWVRTTLTIERWTKE CCCEEEEEEEHHHCC	20.78	29759185
13	Phosphorylation	TLTIERWTKEKTEPK EEEEEHHHCCCCCCC	35.23	22617229
23 (in isoform 2)	Phosphorylation	-	43.68	-
196	Phosphorylation	TQVGPATASPDLGTS CCCCCCCCCCCCCCC	22.60	33259812
218	Methylation	STAPITIWRSESPTG CCCCEEEEECCCCCC	6.79	-
220	Phosphorylation	APITIWRSESPTGKG CCEEEEECCCCCCCC	27.68	30622161
222	Phosphorylation	ITIWRSESPTGKGQG EEEEECCCCCCCCCC	29.07	30622161
224	Phosphorylation	IWRSESPTGKGQGSK EEECCCCCCCCCCHH	61.89	30622161
244	Acetylation	KKKKEKEKDKEEMDE HHHHHHHHCHHHHHH	82.34	8269491
244	Methylation	KKKKEKEKDKEEMDE HHHHHHHHCHHHHHH	82.34	8269491
252	Acetylation	DKEEMDEKAKLKKKA CHHHHHHHHHHHHHH	46.70	8269499
276	Phosphorylation	SPVKLEPSPPDVSRS CCCCCCCCCCCHHHH	39.42	30622161
281	Phosphorylation	EPSPPDVSRSLSARQ CCCCCCHHHHHCHHH	24.43	30622161
283	Phosphorylation	SPPDVSRSLSARQLA CCCCHHHHHCHHHHH	21.12	30622161
285	Phosphorylation	PDVSRSLSARQLARM CCHHHHHCHHHHHHH	23.74	30622161
293	Phosphorylation	ARQLARMSESSPESR HHHHHHHCCCCHHHH	28.86	24719451
295	Phosphorylation	QLARMSESSPESREE HHHHHCCCCHHHHHH	43.84	24719451
296	Phosphorylation	LARMSESSPESREEL HHHHCCCCHHHHHHH	28.74	22210691
299	Phosphorylation	MSESSPESREELESE HCCCCHHHHHHHHCC	48.66	24719451
308	Phosphorylation	EELESEDSYNGRGQG HHHHCCCCCCCCCCC	19.22	-
309	Phosphorylation	ELESEDSYNGRGQGE HHHCCCCCCCCCCCC	33.68	22210691
318	Phosphorylation	GRGQGELSSEDIVES CCCCCCCCHHHHHHC	27.64	25693802
319	Phosphorylation	RGQGELSSEDIVESS CCCCCCCHHHHHHCC	52.49	25693802
355	Phosphorylation	RKVNKRKSPPGSNPN HHCCCCCCCCCCCCC	40.12	30622161
359	Phosphorylation	KRKSPPGSNPNLS-- CCCCCCCCCCCCC--	55.69	30622161
364	Phosphorylation	PGSNPNLS------- CCCCCCCC-------	44.83	30622161

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PRCA1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRCA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRCA1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PRCA1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.