KLDC9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLDC9_HUMAN
• UniProt AC: Q8NEP7
• Protein Name: Kelch domain-containing protein 9
• Gene Name: KLHDC9
• Organism: Homo sapiens (Human).
• Sequence Length: 349
• Protein Sequence: MAVAVPPGRAAGSGWAWRPVARDALLARAFHSCTELRGRFYLVGGLLAGGAREPSSDTVVFDPARGQAVRLGARGSPPRSHHDAAPVDGRWLCVVGGWDGSRRLATVTALDTERGVWEAWTGTPGDCPPAGLSSHTCTRISDRELQVAGREGGIHTQRRYGSIYTLRLDPSARTYCYKQEGCHTASRSGHCAALLQTPGPHPGHQLLLFGGCNLAEPEVAGHWSHGKIKEEPPVAPHLMEQLARLVSSGQGSQKGPHGLRHHSCSVVGPFAVLFGGETLTRARDTICNDLYIYDTRTSPPLWFHFPCADRGMKRMGHRTCLWNDQLYLVGGFGEDGRTASPQVCILDFI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Phosphorylation	TELRGRFYLVGGLLA HHHCCCEEEECCEEC	10.10	22468782
56	Phosphorylation	GGAREPSSDTVVFDP CCCCCCCCCEEEEEC	48.27	22468782
58	Phosphorylation	AREPSSDTVVFDPAR CCCCCCCEEEEECCC	22.10	22468782
101	Phosphorylation	VVGGWDGSRRLATVT EECCCCCCCEEEEEE	16.26	-
106	Phosphorylation	DGSRRLATVTALDTE CCCCEEEEEEEEECC	23.99	23612710
108	Phosphorylation	SRRLATVTALDTERG CCEEEEEEEEECCCC	19.69	30257219
112	Phosphorylation	ATVTALDTERGVWEA EEEEEEECCCCEEEH	28.56	-
121	Phosphorylation	RGVWEAWTGTPGDCP CCEEEHHCCCCCCCC	37.92	-
123	Phosphorylation	VWEAWTGTPGDCPPA EEEHHCCCCCCCCCC	19.40	-
141	Phosphorylation	SHTCTRISDRELQVA CCEECEECCCCEEEC	27.59	-
160	Phosphorylation	GIHTQRRYGSIYTLR CCCCCCCCCCEEEEE	19.88	22817900
162	Phosphorylation	HTQRRYGSIYTLRLD CCCCCCCCEEEEEEC	11.95	28857561
164	Phosphorylation	QRRYGSIYTLRLDPS CCCCCCEEEEEECCC	11.04	22817900
165	Phosphorylation	RRYGSIYTLRLDPSA CCCCCEEEEEECCCC	12.06	24719451
175	Phosphorylation	LDPSARTYCYKQEGC ECCCCCCEEECCCCC	6.55	22817900
177	Phosphorylation	PSARTYCYKQEGCHT CCCCCEEECCCCCCC	12.80	22817900
226 (in isoform 3)	Phosphorylation	-	28.06	30177828
227 (in isoform 3)	Phosphorylation	-	45.22	30177828
231 (in isoform 3)	Phosphorylation	-	50.32	30177828
234 (in isoform 3)	Phosphorylation	-	22.14	30177828
247 (in isoform 3)	Phosphorylation	-	33.09	30177828
338	Phosphorylation	GFGEDGRTASPQVCI CCCCCCCCCCCCEEE	36.70	28348404
340	Phosphorylation	GEDGRTASPQVCILD CCCCCCCCCCEEEEE	18.43	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLDC9_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLDC9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLDC9_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BGAL_HUMAN	GLB1	physical	28514442
PPGB_HUMAN	CTSA	physical	28514442
THOC3_HUMAN	THOC3	physical	28514442
NT5D2_HUMAN	NT5DC2	physical	28514442
DOCK7_HUMAN	DOCK7	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.