UBP18_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBP18_HUMAN
• UniProt AC: Q9UMW8
• Protein Name: Ubl carboxyl-terminal hydrolase 18
• Gene Name: USP18
• Organism: Homo sapiens (Human).
• Sequence Length: 372
• Subcellular Localization: Isoform 1: Cytoplasm .; Isoform 2: Nucleus . Cytoplasm .
• Protein Description: Involved in the regulation of inflammatory response to interferon type 1. [PubMed: 27325888 Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms.; Isoform 2: Has enzymatic activity similar to isoform 1 and interferes with type I interferon signaling. Major deISGylation enzyme for nuclear proteins]
• Protein Sequence: MSKAFGLLRQICQSILAESSQSPADLEEKKEEDSNMKREQPRERPRAWDYPHGLVGLHNIGQTCCLNSLIQVFVMNVDFTRILKRITVPRGADEQRRSVPFQMLLLLEKMQDSRQKAVRPLELAYCLQKCNVPLFVQHDAAQLYLKLWNLIKDQITDVHLVERLQALYTIRVKDSLICVDCAMESSRNSSMLTLPLSLFDVDSKPLKTLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRNSQTRKICHSLYFPQSLDFSQILPMKRESCDAEEQSGGQYELFAVIAHVGMADSGHYCVYIRNAVDGKWFCFNDSNICLVSWEDIQCTYGNPNYHWQETAYLLVYMKMEC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Ubiquitination	-----MSKAFGLLRQ -----CCHHHHHHHH	46.57	-
87	Phosphorylation	TRILKRITVPRGADE HHHHHHCCCCCCCCH	28.61	29496963
125	Phosphorylation	VRPLELAYCLQKCNV CHHHHHHHHHHHCCC	13.30	22461510
130	Ubiquitination	LAYCLQKCNVPLFVQ HHHHHHHCCCCEEEC	3.91	21963094
133	Ubiquitination	CLQKCNVPLFVQHDA HHHHCCCCEEECCCH	13.19	22817900
169	Phosphorylation	ERLQALYTIRVKDSL HHHHHHHHEEECCCE	11.80	24719451
173	Ubiquitination	ALYTIRVKDSLICVD HHHHEEECCCEEEEE	31.58	-
175	Phosphorylation	YTIRVKDSLICVDCA HHEEECCCEEEEECC	17.57	30576142
186	Phosphorylation	VDCAMESSRNSSMLT EECCCCCCCCCCCCC	23.36	30576142
203	Phosphorylation	LSLFDVDSKPLKTLE EHHHCCCCCCCCCHH	35.70	24719451
204	Ubiquitination	SLFDVDSKPLKTLED HHHCCCCCCCCCHHH	50.32	21963094
207	Ubiquitination	DVDSKPLKTLEDALH CCCCCCCCCHHHHHH	60.64	22817900
251	Phosphorylation	KLTHLPQTLTIHLMR HHHCCCCEEEEEEEE	24.75	29038488
253	Phosphorylation	THLPQTLTIHLMRFS HCCCCEEEEEEEEEC	15.11	29038488
260	Phosphorylation	TIHLMRFSIRNSQTR EEEEEEECCCCCCCH	15.41	29496963
268	Ubiquitination	IRNSQTRKICHSLYF CCCCCCHHHHHHCCC	53.74	-
288	Ubiquitination	FSQILPMKRESCDAE HHHHCCCCHHHCCHH	51.58	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	SKP2	Q13309	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBP18_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBP18_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MYL6_HUMAN	MYL6	physical	19615732
NDKA_HUMAN	NME1	physical	19615732
KDM3B_HUMAN	KDM3B	physical	19615732
INAR2_HUMAN	IFNAR2	physical	16710296
PCNA_HUMAN	PCNA	physical	24768535
SKP2_HUMAN	SKP2	physical	25307056
ISG15_HUMAN	ISG15	physical	25307056
HERC1_HUMAN	HERC1	physical	26186194
TM14A_HUMAN	TMEM14A	physical	21516116
IKKA_HUMAN	CHUK	physical	26240016
IKKB_HUMAN	IKBKB	physical	26240016
NEMO_HUMAN	IKBKG	physical	26240016
TAB1_HUMAN	TAB1	physical	23825189
CAR11_HUMAN	CARD11	physical	23825189
TAB2_HUMAN	TAB2	physical	23825189
M3K7_HUMAN	MAP3K7	physical	23825189
STING_HUMAN	TMEM173	physical	27801882
M3K7_HUMAN	MAP3K7	physical	28718215

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.