INAR2_HUMAN - dbPTM
INAR2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID INAR2_HUMAN
UniProt AC P48551
Protein Name Interferon alpha/beta receptor 2
Gene Name IFNAR2
Organism Homo sapiens (Human).
Sequence Length 515
Subcellular Localization Isoform 1: Cell membrane
Single-pass type I membrane protein .
Isoform 2: Cell membrane
Single-pass type I membrane protein .
Isoform 3: Secreted .
Protein Description Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. [PubMed: 26424569 Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1]
Protein Sequence MLLSQNAFIFRSLNLVLMVYISLVFGISYDSPDYTDESCTFKISLRNFRSILSWELKNHSIVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFCDLTDEWRSTHEAYVTVLEGFSGNTTLFSCSHNFWLAIDMSFEPPEFEIVGFTNHINVMVKFPSIVEEELQFDLSLVIEEQSEGIVKKHKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQAVIKSPLKCTLLPPGQESESAESAKIGGIITVFLIALVLTSTIVTLKWIGYICLRNSLPKVLNFHNFLAWPFPNLPPLEAMDMVEVIYINRKKKVWDYNYDDESDSDTEAAPRTSGGGYTMHGLTVRPLGQASATSTESQLIDPESEEEPDLPEVDVELPTMPKDSPQQLELLSGPCERRKSPLQDPFPEEDYSSTEGSGGRITFNVDLNSVFLRVLDDEDSDDLEAPLMLSSHLEEMVDPEDPDNVQSNHLLASGEGTQPTFPSPSSEGLWSEDAPSDQSDTSESDVDLGDGYIMR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
50PhosphorylationISLRNFRSILSWELK
EEECCHHHHHEEECC		24.6022210691
53PhosphorylationRNFRSILSWELKNHS
CCHHHHHEEECCCCC		19.4822210691
58N-linked_GlycosylationILSWELKNHSIVPTH
HHEEECCCCCCCCCE		46.92UniProtKB CARBOHYD
80UbiquitinationMSKPEDLKVVKNCAN
HCCHHHCHHHCHHCC		58.25-
87N-linked_GlycosylationKVVKNCANTTRSFCD
HHHCHHCCCCCHHHH		44.158181059
116N-linked_GlycosylationVLEGFSGNTTLFSCS
EEECCCCCEEEEEEE		28.79UniProtKB CARBOHYD
188N-linked_GlycosylationHKPEIKGNMSGNFTY
CCCCCCCCCCCCEEE		19.22UniProtKB CARBOHYD
192N-linked_GlycosylationIKGNMSGNFTYIIDK
CCCCCCCCEEEEEEE		20.848181059
204PhosphorylationIDKLIPNTNYCVSVY
EEEECCCCCEEEEEE		23.39-
249PhosphorylationAKIGGIITVFLIALV
HHHHHHHHHHHHHHH		11.86-
269PhosphorylationVTLKWIGYICLRNSL
HHHHHHHHHHHHCCH		4.55-
286 (in isoform 2)Ubiquitination-6.22-
305 (in isoform 2)Phosphorylation-1.4825159151
306PhosphorylationMDMVEVIYINRKKKV
HCEEEEEEEECCCEE		9.41-
316PhosphorylationRKKKVWDYNYDDESD
CCCEEECCCCCCCCC		10.4228634120
318PhosphorylationKKVWDYNYDDESDSD
CEEECCCCCCCCCCC		20.6728634120
322PhosphorylationDYNYDDESDSDTEAA
CCCCCCCCCCCCCCC		49.7822115753
324PhosphorylationNYDDESDSDTEAAPR
CCCCCCCCCCCCCCC		56.5722115753
326 (in isoform 2)Phosphorylation-31.3228102081
326PhosphorylationDDESDSDTEAAPRTS
CCCCCCCCCCCCCCC		31.3223663014
330 (in isoform 2)Phosphorylation-47.3228102081
337PhosphorylationPRTSGGGYTMHGLTV
CCCCCCCEEECEEEE		12.2620038197
364PhosphorylationSQLIDPESEEEPDLP
HHCCCCCCCCCCCCC		56.5522817900
384PhosphorylationLPTMPKDSPQQLELL
CCCCCCCCHHHHHHH		30.6330266825
392PhosphorylationPQQLELLSGPCERRK
HHHHHHHHCCCCCCC		54.0026074081
399AcetylationSGPCERRKSPLQDPF
HCCCCCCCCCCCCCC		63.7517923090
400PhosphorylationGPCERRKSPLQDPFP
CCCCCCCCCCCCCCC		29.0923401153
411PhosphorylationDPFPEEDYSSTEGSG
CCCCHHHCCCCCCCC		14.0623927012
412PhosphorylationPFPEEDYSSTEGSGG
CCCHHHCCCCCCCCC		43.0123927012
413PhosphorylationFPEEDYSSTEGSGGR
CCHHHCCCCCCCCCE		25.0123663014
414PhosphorylationPEEDYSSTEGSGGRI
CHHHCCCCCCCCCEE		38.1223663014
417PhosphorylationDYSSTEGSGGRITFN
HCCCCCCCCCEEEEE		31.6623663014
440PhosphorylationRVLDDEDSDDLEAPL
EECCCCCCCCCCHHH		30.8623663014
467PhosphorylationEDPDNVQSNHLLASG
CCCCCCHHCCEEECC		23.18-
483PhosphorylationGTQPTFPSPSSEGLW
CCCCCCCCCCCCCCC		32.9722468782
512PhosphorylationDVDLGDGYIMR----
CCCCCCCCCCC----		9.0421819146
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of INAR2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of INAR2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of INAR2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
IFNA2_HUMANIFNA2physical
10339405
STAT1_HUMANSTAT1physical
9121453
STAT2_HUMANSTAT2physical
9121453
STAT2_HUMANSTAT2physical
11786546
RACK1_HUMANGNB2L1physical
11301323
STAT1_HUMANSTAT1physical
11301323
JAK1_HUMANJAK1physical
12133952
RACK1_HUMANGNB2L1physical
11046044
IRF9_HUMANIRF9physical
17923090
CBP_HUMANCREBBPphysical
17923090
INAR2_HUMANIFNAR2physical
17923090
STAT2_HUMANSTAT2physical
17923090
UBP18_HUMANUSP18physical
16710296
JAK1_HUMANJAK1physical
16710296
PPR3B_HUMANPPP1R3Bphysical
21988832
GRAP2_HUMANGRAP2physical
26186194
UBP18_HUMANUSP18physical
27716962
GRAP2_HUMANGRAP2physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D00745 Interferon alfa-2a (genetical recombination) (JAN); Interferon alfa-2a (USAN/INN); Roferon A (TN)
D00746 Interferon beta-1b (genetical recombination) (JAN); Interferon beta-1b (USAN/INN); Betaseron (TN); E
D02744 Interferon alfacon-1 (genetical recombination) (JAN); Interferon alfacon-1 (USAN/INN); Advaferon (TN
D02745 Interferon alfa-2b (genetical recombination) (JAN); Interferon alfa-2b (USAN); Intron A (TN)
D02747 Peginterferon alfa-2a (genetical recombination) (JAN); Peginterferon alfa-2a (USAN/INN); Pegasys (TN
D02748 Peginterferon alfa-2b (generical recombination) (JAN); Peginterferon alfa-2b (INN); Pegintron (TN);
D03304 Interferon beta (JAN); Feron (TN)
D03305 Interferon alfa (BALL-1) (JAN); Interferon alfa (NAMAWA) (JAN); Interferon alfa (INN); OIF (TN)
D04552 Interferon alfa-n1 (USAN); alfa-Interferon; Well-feron (TN)
D04554 Interferon beta-1a (genetical recombination) (JAN); Interferon beta-1a (USAN); Avonex (TN); Rebif (T
D08844 Albinterferon alfa-2b (USAN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of INAR2_HUMAN

loading...

Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"The human interferon alpha/beta receptor: characterization andmolecular cloning.";
Novick D., Cohen B., Rubinstein M.;
Cell 77:391-400(1994).
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), PARTIAL PROTEIN SEQUENCE,GLYCOSYLATION AT ASN-87 AND ASN-192, FUNCTION, SUBCELLULAR LOCATION,TISSUE SPECIFICITY, AND VARIANT VAL-10.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory