IRF9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IRF9_HUMAN
• UniProt AC: Q00978
• Protein Name: Interferon regulatory factor 9
• Gene Name: IRF9
• Organism: Homo sapiens (Human).
• Sequence Length: 393
• Subcellular Localization: Cytoplasm . Nucleus . Translocated into the nucleus upon activation by IFN-alpha/beta.
• Protein Description: Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state..
• Protein Sequence: MASGRARCTRKLRNWVVEQVESGQFPGVCWDDTAKTMFRIPWKHAGKQDFREDQDAAFFKAWAIFKGKYKEGDTGGPAVWKTRLRCALNKSSEFKEVPERGRMDVAEPYKVYQLLPPGIVSGQPGTQKVPSKRQHSSVSSERKEEEDAMQNCTLSPSVLQDSLNNEEEGASGGAVHSDIGSSSSSSSPEPQEVTDTTEAPFQGDQRSLEFLLPPEPDYSLLLTFIYNGRVVGEAQVQSLDCRLVAEPSGSESSMEQVLFPKPGPLEPTQRLLSQLERGILVASNPRGLFVQRLCPIPISWNAPQAPPGPGPHLLPSNECVELFRTAYFCRDLVRYFQGLGPPPKFQVTLNFWEESHGSSHTPQNLITVKMEQAFARYLLEQTPEQQAAILSLV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	Acetylation	TMFRIPWKHAGKQDF CCEECCCHHCCCCCC	20.44	17923090
47	Ubiquitination	IPWKHAGKQDFREDQ CCCHHCCCCCCCHHH	47.69	29967540
47	Acetylation	IPWKHAGKQDFREDQ CCCHHCCCCCCCHHH	47.69	17923090
68	Acetylation	AWAIFKGKYKEGDTG HHHHHCCCCCCCCCC	54.46	17923090
81	Ubiquitination	TGGPAVWKTRLRCAL CCCCHHHHHHHHHHH	19.71	29967540
81	Acetylation	TGGPAVWKTRLRCAL CCCCHHHHHHHHHHH	19.71	17923090
90	Acetylation	RLRCALNKSSEFKEV HHHHHHCCCCCCCCC	57.09	17923090
110	Acetylation	MDVAEPYKVYQLLPP CCCCCCCEEEECCCC	45.22	17923090
128	Acetylation	SGQPGTQKVPSKRQH CCCCCCCCCCCCCCC	56.82	17923090
131	Phosphorylation	PGTQKVPSKRQHSSV CCCCCCCCCCCCCCC	43.38	27251275
132	Acetylation	GTQKVPSKRQHSSVS CCCCCCCCCCCCCCC	50.43	17923090
136	Phosphorylation	VPSKRQHSSVSSERK CCCCCCCCCCCCCHH	24.89	26699800
137	Phosphorylation	PSKRQHSSVSSERKE CCCCCCCCCCCCHHH	24.72	26699800
139	Phosphorylation	KRQHSSVSSERKEEE CCCCCCCCCCHHHHH	28.56	26699800
140	Phosphorylation	RQHSSVSSERKEEED CCCCCCCCCHHHHHH	38.99	26699800
238	Phosphorylation	VGEAQVQSLDCRLVA CEEEEECCCEEEEEE	27.58	30108239
248	Phosphorylation	CRLVAEPSGSESSME EEEEEECCCCCCCCC	46.59	28348404
250	Phosphorylation	LVAEPSGSESSMEQV EEEECCCCCCCCCCC	38.35	28348404
252	Phosphorylation	AEPSGSESSMEQVLF EECCCCCCCCCCCCC	36.36	24719451
253	Phosphorylation	EPSGSESSMEQVLFP ECCCCCCCCCCCCCC	23.45	28348404
273	Phosphorylation	EPTQRLLSQLERGIL CHHHHHHHHHHHCEE	36.99	24247654
361	Phosphorylation	ESHGSSHTPQNLITV HHCCCCCCCCCEEEE	28.63	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IRF9_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IRF9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IRF9_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STAT1_HUMAN	STAT1	physical	8943351
STAT2_HUMAN	STAT2	physical	8943351
STAT2_HUMAN	STAT2	physical	9242679
ARI3B_HUMAN	ARID3B	physical	20211142
VENTX_HUMAN	VENTX	physical	20211142
TLX3_HUMAN	TLX3	physical	20211142
DMRTD_HUMAN	DMRTC2	physical	20211142
DACH2_HUMAN	DACH2	physical	20211142
STAT2_HUMAN	STAT2	physical	21903422
IRF1_HUMAN	IRF1	physical	12799427
I2BP1_HUMAN	IRF2BP1	physical	12799427
MYO1F_HUMAN	MYO1F	physical	21988832
S10AD_HUMAN	S100A13	physical	21988832
STAT2_HUMAN	STAT2	physical	28514442
RAD18_HUMAN	RAD18	physical	28514442
UB2R2_HUMAN	UBE2R2	physical	28514442
ARI1_HUMAN	ARIH1	physical	28514442
FBLN1_HUMAN	FBLN1	physical	28514442
ANKH1_HUMAN	ANKHD1	physical	28514442
ANR17_HUMAN	ANKRD17	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.