| UniProt ID | TLX3_HUMAN | |
|---|---|---|
| UniProt AC | O43711 | |
| Protein Name | T-cell leukemia homeobox protein 3 | |
| Gene Name | TLX3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 291 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | ||
| Protein Sequence | MEAPASAQTPHPHEPISFGIDQILNSPDQDSAPAPRGPDGASYLGGPPGGRPGATYPSLPASFAGLGAPFEDAGSYSVNLSLAPAGVIRVPAHRPLPGAVPPPLPSALPAMPSVPTVSSLGGLNFPWMESSRRFVKDRFTAAAALTPFTVTRRIGHPYQNRTPPKRKKPRTSFSRVQICELEKRFHRQKYLASAERAALAKSLKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQASRLMLQLQHDAFQKSLNDSIQPDPLCLHNSSLFALQNLQPWEEDSSKVPAVTSLV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 76 | Phosphorylation | PFEDAGSYSVNLSLA CCCCCCCEEEEEEEC | 18.73 | - | |
| 146 | Phosphorylation | FTAAAALTPFTVTRR HHHHHHCCCHHEEEC | 16.19 | 28555341 | |
| 158 | Phosphorylation | TRRIGHPYQNRTPPK EECCCCCCCCCCCCC | 16.85 | 29214152 | |
| 162 | Phosphorylation | GHPYQNRTPPKRKKP CCCCCCCCCCCCCCC | 52.04 | 28152594 | |
| 190 | Phosphorylation | KRFHRQKYLASAERA HHHHHHHHHHHHHHH | 10.12 | - | |
| 193 | Phosphorylation | HRQKYLASAERAALA HHHHHHHHHHHHHHH | 28.24 | - | |
| 201 | Ubiquitination | AERAALAKSLKMTDA HHHHHHHHHHCCCHH | 58.11 | 29967540 | |
| 202 | Phosphorylation | ERAALAKSLKMTDAQ HHHHHHHHHCCCHHH | 27.84 | - | |
| 212 | Phosphorylation | MTDAQVKTWFQNRRT CCHHHHHHHHHHHHH | 32.43 | 22817900 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TLX3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TLX3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TLX3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ING4_HUMAN | ING4 | physical | 20211142 | |
| HOP_HUMAN | HOPX | physical | 20211142 | |
| TLE1_HUMAN | TLE1 | physical | 19250647 | |
| PP1G_HUMAN | PPP1CC | physical | 19250647 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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