| UniProt ID | LRC58_HUMAN | |
|---|---|---|
| UniProt AC | Q96CX6 | |
| Protein Name | Leucine-rich repeat-containing protein 58 | |
| Gene Name | LRRC58 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 371 | |
| Subcellular Localization | ||
| Protein Description | ||
| Protein Sequence | MEEAGAAVVTAGEAELNWSRLSVSTETLESELEARGEERRGAREALLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPLVVRFVRDLTYDPPTLLELAARTIKIRNISYTPYDLPGNLLRYLGSASNCPNPKCGGVYFDCCVRQIKFVDFCGKYRLPLMHYLCSPECSSPCSSASHSSTSQSESDSEDEASVAARRMQKVLLG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 19 | Phosphorylation | GEAELNWSRLSVSTE CCEEECCEEEEEEHH | 23.44 | 24719451 | |
| 22 | Phosphorylation | ELNWSRLSVSTETLE EECCEEEEEEHHHHH | 16.95 | 28857561 | |
| 24 | Phosphorylation | NWSRLSVSTETLESE CCEEEEEEHHHHHHH | 19.70 | 28450419 | |
| 25 | Phosphorylation | WSRLSVSTETLESEL CEEEEEEHHHHHHHH | 30.73 | 27732954 | |
| 58 | Phosphorylation | LPHNRLVSLPRALGS CCCCHHHHHHHHHCC | 36.93 | 19664995 | |
| 99 | Ubiquitination | GLRTLLAKNNRLGGP HHHHHHHHCCCCCCC | 55.51 | 22505724 | |
| 107 | Phosphorylation | NNRLGGPSALPKGLA CCCCCCCCCCCCCHH | 45.79 | 17192257 | |
| 111 | Ubiquitination | GGPSALPKGLAQSPL CCCCCCCCCHHCCHH | 68.36 | 23000965 | |
| 193 | Phosphorylation | GNLPSLNYLVLCDNK CCCCCCCEEEEECCC | 11.95 | - | |
| 200 | Ubiquitination | YLVLCDNKIQSIPPQ EEEEECCCCCCCCCC | 28.95 | 21963094 | |
| 225 | Phosphorylation | SLHNNLLTYLPREIL CCCCCHHHHCHHHHH | 26.61 | 27732954 | |
| 226 | Phosphorylation | LHNNLLTYLPREILN CCCCHHHHCHHHHHH | 18.06 | 27732954 | |
| 241 | Phosphorylation | LIHLEELSLRGNPLV HHCHHHHHHCCCCEE | 21.21 | 24719451 | |
| 280 | Phosphorylation | RNISYTPYDLPGNLL EECEECCCCCCCCHH | 23.47 | 18083107 | |
| 300 | Ubiquitination | ASNCPNPKCGGVYFD CCCCCCCCCCCEEEE | 52.75 | 21963094 | |
| 314 | Ubiquitination | DCCVRQIKFVDFCGK EEEEEEEEEECCCCC | 30.88 | - | |
| 321 | Ubiquitination | KFVDFCGKYRLPLMH EEECCCCCCCCCCCC | 28.51 | 21963094 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of LRC58_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of LRC58_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of LRC58_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of LRC58_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24, AND MASSSPECTROMETRY. | |
