dbPTM

MON1A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MON1A_HUMAN
UniProt AC	Q86VX9
Protein Name	Vacuolar fusion protein MON1 homolog A
Gene Name	MON1A
Organism	Homo sapiens (Human).
Sequence Length	652
Subcellular Localization
Protein Description	Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (By similarity). Acts in concert with CCZ1, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. [PubMed: 23084991]
Protein Sequence	MHPGGGPSRAERLELGLGRERPAKAIFLHRRPGEGGGRERCLRCGHVCVRRGPGPREAVPSGRPRPDTLTPPWVRQRAVTGTFCASWTPLRNRRAQRMATDMQRKRSSECLDGTLTPSDGQSMERAESPTPGMAQGMEPGAGQEGAMFVHARSYEDLTESEDGAASGDSHKEGTRGPPPLPTDMRQISQDFSELSTQLTGVARDLQEEMLPGSSEDWLEPPGAVGRPATEPPREGTTEGDEEDATEAWRLHQKHVFVLSEAGKPVYSRYGSEEALSSTMGVMVALVSFLEADKNAIRSIHADGYKVVFVRRSPLVLVAVARTRQSAQELAQELLYIYYQILSLLTGAQLSHIFQQKQNYDLRRLLSGSERITDNLLQLMARDPSFLMGAARCLPLAAAVRDTVSASLQQARARSLVFSILLARNQLVALVRRKDQFLHPIDLHLLFNLISSSSSFREGEAWTPVCLPKFNAAGFFHAHISYLEPDTDLCLLLVSTDREDFFAVSDCRRRFQERLRKRGAHLALREALRTPYYSVAQVGIPDLRHFLYKSKSSGLFTSPEIEAPYTSEEEQERLLGLYQYLHSRAHNASRPLKTIYYTGPNENLLAWVTGAFELYMCYSPLGTKASAVSAIHKLMRWIRKEEDRLFILTPLTY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	PGGGPSRAERLELGL CCCCCCHHHHHHHCC	33.26	23401153
11	Phosphorylation	GGGPSRAERLELGLG CCCCCHHHHHHHCCC	36.04	23927012
17	Phosphorylation	AERLELGLGRERPAK HHHHHHCCCCCCCCE	27.42	29496963
19	Phosphorylation	RLELGLGRERPAKAI HHHHCCCCCCCCEEE	22.15	23312004
21	Phosphorylation	ELGLGRERPAKAIFL HHCCCCCCCCEEEEE	49.49	23312004
31	Phosphorylation	KAIFLHRRPGEGGGR EEEEEECCCCCCCCC	32.84	23401153
33	Phosphorylation	IFLHRRPGEGGGRER EEEECCCCCCCCCHH	41.58	29255136
56	Phosphorylation	VRRGPGPREAVPSGR EECCCCCHHCCCCCC	33.39	22167270
57	Phosphorylation	RRGPGPREAVPSGRP ECCCCCHHCCCCCCC	14.12	22167270
61	Phosphorylation	GPREAVPSGRPRPDT CCHHCCCCCCCCCCC	50.19	23927012
63	Phosphorylation	REAVPSGRPRPDTLT HHCCCCCCCCCCCCC	35.43	23403867
68	Phosphorylation	SGRPRPDTLTPPWVR CCCCCCCCCCCCCHH	21.41	24719451
68 (in isoform 4)	Phosphorylation	-	21.41	24719451
68	Phosphorylation	SGRPRPDTLTPPWVR CCCCCCCCCCCCCHH	21.41	24719451
69	Phosphorylation	GRPRPDTLTPPWVRQ CCCCCCCCCCCCHHH	42.47	23403867
70	Phosphorylation	RPRPDTLTPPWVRQR CCCCCCCCCCCHHHC	35.40	24719451
70	Phosphorylation	RPRPDTLTPPWVRQR CCCCCCCCCCCHHHC	35.40	24719451
70 (in isoform 4)	Phosphorylation	-	35.40	24719451
72	Phosphorylation	RPDTLTPPWVRQRAV CCCCCCCCCHHHCCC	39.73	23403867
77	Phosphorylation	TPPWVRQRAVTGTFC CCCCHHHCCCCCCCC	33.28	23186163
91	Phosphorylation	CASWTPLRNRRAQRM CCCCHHHHCHHHHHH	18.50	23898821
95	Phosphorylation	TPLRNRRAQRMATDM HHHHCHHHHHHHHHH	46.01	28464451
98	Phosphorylation	RNRRAQRMATDMQRK HCHHHHHHHHHHHHH	15.28	28450419
99	Phosphorylation	NRRAQRMATDMQRKR CHHHHHHHHHHHHHH	39.98	-
100	Phosphorylation	RRAQRMATDMQRKRS HHHHHHHHHHHHHHH	33.38	22210691
100 (in isoform 4)	Phosphorylation	-	33.38	22210691
102	Phosphorylation	AQRMATDMQRKRSSE HHHHHHHHHHHHHHH	21.57	-
107	Phosphorylation	TDMQRKRSSECLDGT HHHHHHHHHHCCCCC	42.86	24719451
108	Phosphorylation	DMQRKRSSECLDGTL HHHHHHHHHCCCCCC	6.02	29743597
108 (in isoform 4)	Phosphorylation	-	6.02	29743597
108	Phosphorylation	DMQRKRSSECLDGTL HHHHHHHHHCCCCCC	6.02	-
128	Phosphorylation	QSMERAESPTPGMAQ CCCCCCCCCCCCCCC	29.35	23186163
153	Phosphorylation	AMFVHARSYEDLTES CEEEEEECHHHCCCC	3.32	33259812
154	Phosphorylation	MFVHARSYEDLTESE EEEEEECHHHCCCCC	26.52	18452278
158	Phosphorylation	ARSYEDLTESEDGAA EECHHHCCCCCCCCC	4.58	23186163
160	Phosphorylation	SYEDLTESEDGAASG CHHHCCCCCCCCCCC	5.82	27251275
166	Ubiquitination	ESEDGAASGDSHKEG CCCCCCCCCCCCCCC	38.06	-
188	Phosphorylation	PTDMRQISQDFSELS CCCHHHHHHHHHHHH	1.95	24719451
215	Phosphorylation	EMLPGSSEDWLEPPG HCCCCCCCCCCCCCC	16.42	22210691
263	Ubiquitination	FVLSEAGKPVYSRYG EEEECCCCCCCCCCC	41.05	-
275	Phosphorylation	RYGSEEALSSTMGVM CCCCHHHHHHHHHHH	25.67	29759185
287	Phosphorylation	GVMVALVSFLEADKN HHHHHHHHHHHHCHH	34.99	29759185
291 (in isoform 2)	Ubiquitination	-	20.45	21906983
317	Phosphorylation	RRSPLVLVAVARTRQ ECCCCHHEEHHCCHH	28.09	26434776
321	Phosphorylation	LVLVAVARTRQSAQE CHHEEHHCCHHHHHH	12.59	26434776
353	Phosphorylation	GAQLSHIFQQKQNYD HHHHHHHHHHHCCCC	27.60	-
365	Phosphorylation	NYDLRRLLSGSERIT CCCHHHHHCCCHHHH	16.94	24850871
386	Ubiquitination	MARDPSFLMGAARCL HHCCHHHHHHHHHHH	32.66	22817900
388	Ubiquitination	RDPSFLMGAARCLPL CCHHHHHHHHHHHHH	43.40	22817900
450	Phosphorylation	HLLFNLISSSSSFRE HHHHHHHHCCCCCCC	16.57	-
451	Ubiquitination	LLFNLISSSSSFREG HHHHHHHCCCCCCCC	54.26	22817900
453	Ubiquitination	FNLISSSSSFREGEA HHHHHCCCCCCCCCC	44.48	22817900
453 (in isoform 1)	Ubiquitination	-	44.48	21906983
454	Phosphorylation	NLISSSSSFREGEAW HHHHCCCCCCCCCCC	36.41	23403867
455	Phosphorylation	LISSSSSFREGEAWT HHHCCCCCCCCCCCC	43.16	23403867
459	Phosphorylation	SSSFREGEAWTPVCL CCCCCCCCCCCCEEC	48.71	23403867
460	Phosphorylation	SSFREGEAWTPVCLP CCCCCCCCCCCEECC	17.13	23403867
468	Phosphorylation	WTPVCLPKFNAAGFF CCCEECCCCCCCCEE	28.71	23403867
482	Phosphorylation	FHAHISYLEPDTDLC EEEEEECCCCCCCEE	7.88	23403867
528	Phosphorylation	LALREALRTPYYSVA HHHHHHHCCCCCCHH	30.66	-
531	Phosphorylation	REALRTPYYSVAQVG HHHHCCCCCCHHHCC	22.63	28857561
548	Ubiquitination	DLRHFLYKSKSSGLF HHHHHHHHCCCCCCC	4.47	22817900
550	Ubiquitination	RHFLYKSKSSGLFTS HHHHHHCCCCCCCCC	2.94	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MON1A_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MON1A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MON1A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
RABX5_HUMAN	RABGEF1	physical	20434987
VP33A_HUMAN	VPS33A	physical	20434987

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MON1A_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, AND MASSSPECTROMETRY.	18669648 [Abstract]