dbPTM

MET18_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MET18_HUMAN
UniProt AC	O95568
Protein Name	Histidine protein methyltransferase 1 homolog
Gene Name	METTL18
Organism	Homo sapiens (Human).
Sequence Length	372
Subcellular Localization
Protein Description	Probable histidine methyltransferase..
Protein Sequence	MTFQFNFTIEDHLENELTPIRDGALTLDSSKELSVSESQKGEERDRKCSAEQFDLPQDHLWEHKSMENAAPSQDTDSPLSAASSSRNLEPHGKQPSLRAAKEHAMPKDLKKMLENKVIETLPGFQHVKLSVVKTILLKENFPGENIVSKSFSSHSDLITGVYEGGLKIWECTFDLLAYFTKAKVKFAGKKVLDLGCGSGLLGITAFKGGSKEIHFQDYNSMVIDEVTLPNVVANSTLEDEENDVNEPDVKRCRKPKVTQLYKCRFFSGEWSEFCKLVLSSEKLFVKYDLILTSETIYNPDYYSNLHQTFLRLLSKNGRVLLASKAHYFGVGGGVHLFQKFVEERDVFKTRILKIIDEGLKRFIIEITFKFPG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	DHLENELTPIRDGAL HHHHCCCCCCCCCCE	15.53	-
30	Phosphorylation	GALTLDSSKELSVSE CCEEECCCCCCCCCH	29.80	21815630
36	Phosphorylation	SSKELSVSESQKGEE CCCCCCCCHHHCCHH	28.31	25159151
38	Phosphorylation	KELSVSESQKGEERD CCCCCCHHHCCHHHH	29.68	29523821
49	Phosphorylation	EERDRKCSAEQFDLP HHHHHCCCHHHCCCC	37.56	27251275
65	Phosphorylation	DHLWEHKSMENAAPS HHHHCCCCCCCCCCC	32.98	27251275
72	Phosphorylation	SMENAAPSQDTDSPL CCCCCCCCCCCCCCH	35.64	17525332
75	Phosphorylation	NAAPSQDTDSPLSAA CCCCCCCCCCCHHHH	30.64	22199227
77	Phosphorylation	APSQDTDSPLSAASS CCCCCCCCCHHHHHH	29.81	25159151
80	Phosphorylation	QDTDSPLSAASSSRN CCCCCCHHHHHHCCC	25.77	22199227
83	Phosphorylation	DSPLSAASSSRNLEP CCCHHHHHHCCCCCC	28.67	22199227
84	Phosphorylation	SPLSAASSSRNLEPH CCHHHHHHCCCCCCC	28.70	22199227
85	Phosphorylation	PLSAASSSRNLEPHG CHHHHHHCCCCCCCC	23.77	22199227
96	Phosphorylation	EPHGKQPSLRAAKEH CCCCCCHHHHHHHHH	28.17	23403867
297	Phosphorylation	ILTSETIYNPDYYSN EEECCCCCCCCHHHH	28.23	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MET18_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MET18_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MET18_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HS90A_HUMAN	HSP90AA1	physical	23349634
HSP74_HUMAN	HSPA4	physical	23349634
GRWD1_HUMAN	GRWD1	physical	23349634
RL3_HUMAN	RPL3	physical	23349634
ANXA6_HUMAN	ANXA6	physical	23349634
TCPB_HUMAN	CCT2	physical	23349634
TCPG_HUMAN	CCT3	physical	23349634
TCPD_HUMAN	CCT4	physical	23349634
TCPZ_HUMAN	CCT6A	physical	23349634
TCPW_HUMAN	CCT6B	physical	23349634
TCPH_HUMAN	CCT7	physical	23349634
TCPQ_HUMAN	CCT8	physical	23349634
EIF3I_HUMAN	EIF3I	physical	23349634
EIF3K_HUMAN	EIF3K	physical	23349634
H1X_HUMAN	H1FX	physical	23349634
GRP78_HUMAN	HSPA5	physical	23349634
SYIC_HUMAN	IARS	physical	23349634
IPO7_HUMAN	IPO7	physical	23349634
KDM1A_HUMAN	KDM1A	physical	23349634
HNRC3_HUMAN	HNRNPCL3	physical	23349634
TRMB_HUMAN	METTL1	physical	23349634
RM49_HUMAN	MRPL49	physical	23349634
RPAB3_HUMAN	POLR2H	physical	23349634
PPIH_HUMAN	PPIH	physical	23349634
PRP4_HUMAN	PRPF4	physical	23349634
SYRC_HUMAN	RARS	physical	23349634
RUVB1_HUMAN	RUVBL1	physical	23349634
RUVB2_HUMAN	RUVBL2	physical	23349634
RU2A_HUMAN	SNRPA1	physical	23349634
SMD2_HUMAN	SNRPD2	physical	23349634
RUXF_HUMAN	SNRPF	physical	23349634
SRP14_HUMAN	SRP14	physical	23349634
SRP68_HUMAN	SRP68	physical	23349634
SRP72_HUMAN	SRP72	physical	23349634
SRP09_HUMAN	SRP9	physical	23349634
TCPA_HUMAN	TCP1	physical	23349634
RO60_HUMAN	TROVE2	physical	23349634
GCP2_HUMAN	TUBGCP2	physical	23349634
LAMB4_HUMAN	LAMB4	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MET18_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77, AND MASSSPECTROMETRY.	18669648 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-72, AND MASSSPECTROMETRY.	17525332 [Abstract]