RIN3_HUMAN - dbPTM
RIN3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RIN3_HUMAN
UniProt AC Q8TB24
Protein Name Ras and Rab interactor 3
Gene Name RIN3
Organism Homo sapiens (Human).
Sequence Length 985
Subcellular Localization Cytoplasm . Cytoplasmic vesicle . Early endosome . Activation of tyrosine phosphorylation signaling induces translocation to cytoplasmic vesicles.
Protein Description Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function..
Protein Sequence MIRHAGAPARGDPTGPVPVVGKGEEEEEEDGMRLCLPANPKNCLPHRRGISILEKLIKTCPVWLQLSLGQAEVARILHRVVAGMFLVRRDSSSKQLVLCVHFPSLNESSAEVLEYTIKEEKSILYLEGSALVFEDIFRLIAFYCVSRDLLPFTLRLPQAILEASSFTDLETIANLGLGFWDSSLNPPQERGKPAEPPRDRAPGFPLVSSLRPTAHDANCACEIELSVGNDRLWFVNPIFIEDCSSALPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLPALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPPRKKRISRQLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSPEFKGSLASLSDSLGVSVMATDQDSYSTSSTEEELEQFSSPSVKKKPSMILGKARHRLSFASFSSMFHAFLSNNRKLYKKVVELAQDKGSYFGSLVQDYKVYSLEMMARQTSSTEMLQEIRTMMTQLKSYLLQSTELKALVDPALHSEEELEAIVESALYKCVLKPLKEAINSCLHQIHSKDGSLQQLKENQLVILATTTTDLGVTTSVPEVPMMEKILQKFTSMHKAYSPEKKISILLKTCKLIYDSMALGNPGKPYGADDFLPVLMYVLARSNLTEMLLNVEYMMELMDPALQLGEGSYYLTTTYGALEHIKSYDKITVTRQLSVEVQDSIHRWERRRTLNKARASRSSVQDFICVSYLEPEQQARTLASRADTQAQALCAQCAEKFAVERPQAHRLFVLVDGRCFQLADDALPHCIKGYLLRSEPKRDFHFVYRPLDGGGGGGGGSPPCLVVREPNFL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Methylation-----MIRHAGAPAR
-----CCCCCCCCCC		16.59115491273
51PhosphorylationLPHRRGISILEKLIK
CCCHHHHHHHHHHHH		24.7624719451
153PhosphorylationSRDLLPFTLRLPQAI
CCCCHHHHCCCCHHH		14.7224719451
208PhosphorylationAPGFPLVSSLRPTAH
CCCCCEEECCCCCCC		31.1924719451
209PhosphorylationPGFPLVSSLRPTAHD
CCCCEEECCCCCCCC		22.4024719451
265PhosphorylationPARPLPPTSDATSPT
CCCCCCCCCCCCCCC		36.9828348404
266PhosphorylationARPLPPTSDATSPTS
CCCCCCCCCCCCCCC		30.9028348404
269PhosphorylationLPPTSDATSPTSRWA
CCCCCCCCCCCCCCC		39.9825850435
270PhosphorylationPPTSDATSPTSRWAP
CCCCCCCCCCCCCCC		28.0925850435
272PhosphorylationTSDATSPTSRWAPRR
CCCCCCCCCCCCCCC		30.5925850435
273PhosphorylationSDATSPTSRWAPRRP
CCCCCCCCCCCCCCC		29.2525850435
392PhosphorylationAPPRRRVSERVSLED
CCCCCCHHCCCCCCC		20.2029978859
396PhosphorylationRRVSERVSLEDQSPG
CCHHCCCCCCCCCCC		32.0629978859
401PhosphorylationRVSLEDQSPGMAAEG
CCCCCCCCCCCCCCC		35.4229978859
412PhosphorylationAAEGDQLSLPPQGTS
CCCCCCCCCCCCCCC		32.9529978859
418PhosphorylationLSLPPQGTSDGPEDT
CCCCCCCCCCCCCCC		20.5629978859
419PhosphorylationSLPPQGTSDGPEDTP
CCCCCCCCCCCCCCC		47.6029978859
445PhosphorylationVKASDPHSMPELPRT
CCCCCCCCCCCCCCC		41.2327251275
494PhosphorylationAMALETPTPGPPREG
HHHCCCCCCCCCCCC		48.5821815630
503PhosphorylationGPPREGQSPASQAGT
CCCCCCCCCHHHCCC		33.0328450419
506PhosphorylationREGQSPASQAGTQHP
CCCCCCHHHCCCCCC		24.7723401153
510PhosphorylationSPASQAGTQHPPAQA
CCHHHCCCCCCCCCC		27.0723401153
518PhosphorylationQHPPAQATAHSQSSP
CCCCCCCCCCCCCCH		16.9023401153
521PhosphorylationPAQATAHSQSSPEFK
CCCCCCCCCCCHHHC		29.3223401153
523PhosphorylationQATAHSQSSPEFKGS
CCCCCCCCCHHHCHH		51.3726657352
524PhosphorylationATAHSQSSPEFKGSL
CCCCCCCCHHHCHHH		22.3226657352
572PhosphorylationPSVKKKPSMILGKAR
CCCCCCHHHHHHHHH		27.60-
583PhosphorylationGKARHRLSFASFSSM
HHHHHCCCHHHHHHH		20.8027251275
586PhosphorylationRHRLSFASFSSMFHA
HHCCCHHHHHHHHHH		24.5327251275
635PhosphorylationLEMMARQTSSTEMLQ
HHHHHHCCCCHHHHH		21.0630576142
636PhosphorylationEMMARQTSSTEMLQE
HHHHHCCCCHHHHHH		27.2421712546
649PhosphorylationQEIRTMMTQLKSYLL
HHHHHHHHHHHHHHH		21.6725332170
658PhosphorylationLKSYLLQSTELKALV
HHHHHHHHHHHHHHH		24.6625690035
659PhosphorylationKSYLLQSTELKALVD
HHHHHHHHHHHHHHC		32.1725690035
708PhosphorylationQIHSKDGSLQQLKEN
HHHCCCCHHHHHHHC		32.8922985185
765PhosphorylationKISILLKTCKLIYDS
HHHHHHHHHHHHHHH		18.1617929957
782PhosphorylationLGNPGKPYGADDFLP
HCCCCCCCCHHHHHH		28.56-
793PhosphorylationDFLPVLMYVLARSNL
HHHHHHHHHHHHCCH		6.53-
850PhosphorylationITVTRQLSVEVQDSI
EEEEEEEEHHHHHHH		14.1130108239
872PhosphorylationTLNKARASRSSVQDF
HHHHHHHCCHHHCCE		27.4328270605
874PhosphorylationNKARASRSSVQDFIC
HHHHHCCHHHCCEEE		32.1628450419
875PhosphorylationKARASRSSVQDFICV
HHHHCCHHHCCEEEE		23.7626657352
883PhosphorylationVQDFICVSYLEPEQQ
HCCEEEEHHCCHHHH		21.4228270605
884PhosphorylationQDFICVSYLEPEQQA
CCEEEEHHCCHHHHH		8.4928270605
893PhosphorylationEPEQQARTLASRADT
CHHHHHHHHHHHHHH		29.68-
896PhosphorylationQQARTLASRADTQAQ
HHHHHHHHHHHHHHH		30.98-
960PhosphorylationKRDFHFVYRPLDGGG
CCCEEEEEEECCCCC		12.9328270605
973PhosphorylationGGGGGGGSPPCLVVR
CCCCCCCCCCEEEEC		29.0128270605
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RIN3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RIN3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RIN3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RAB5B_HUMANRAB5Bphysical
12972505
ASB8_HUMANASB8physical
25814554
DOK3_HUMANDOK3physical
25814554
RTL8B_HUMANFAM127Cphysical
25814554
MPEG1_HUMANMPEG1physical
25814554
PLB1_HUMANPLB1physical
25814554
SPT12_HUMANSPATA12physical
25814554
SPY4_HUMANSPRY4physical
25814554
T4S19_HUMANTM4SF19physical
25814554
TSSK3_HUMANTSSK3physical
25814554
ASB3_HUMANASB3physical
25814554
CRK_HUMANCRKphysical
25814554
CRKL_HUMANCRKLphysical
25814554
CSRP3_HUMANCSRP3physical
25814554
CP2C8_HUMANCYP2C8physical
25814554
CP46A_HUMANCYP46A1physical
25814554
ES8L2_HUMANEPS8L2physical
25814554
EZH2_HUMANEZH2physical
25814554
FA46A_HUMANFAM46Aphysical
25814554
GATA1_HUMANGATA1physical
25814554
GRAP2_HUMANGRAP2physical
25814554
ID2_HUMANID2physical
25814554
KCD17_HUMANKCTD17physical
25814554
LCK_HUMANLCKphysical
25814554
MT2_HUMANMT2Aphysical
25814554
RPC6_HUMANPOLR3Fphysical
25814554
PSMD9_HUMANPSMD9physical
25814554
SUV91_HUMANSUV39H1physical
25814554
SYMPK_HUMANSYMPKphysical
25814554
TGM1_HUMANTGM1physical
25814554
TSC1_HUMANTSC1physical
25814554
ZBT24_HUMANZBTB24physical
25814554
ZN639_HUMANZNF639physical
25814554
ZN655_HUMANZNF655physical
25814554
ZNF71_HUMANZNF71physical
25814554
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RIN3_HUMAN

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Related Literatures of Post-Translational Modification

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