PLB1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLB1_HUMAN
• UniProt AC: Q6P1J6
• Protein Name: Phospholipase B1, membrane-associated
• Gene Name: PLB1
• Organism: Homo sapiens (Human).
• Sequence Length: 1458
• Subcellular Localization: Apical cell membrane; Single-pass type I membrane protein. Present in the intestinal brush border membranes..
• Protein Description: Membrane-associated phospholipase. Exhibits a calcium-independent broad substrate specificity including phospholipase A2/lysophospholipase activity. Preferential hydrolysis at the sn-2 position of diacylphospholipids and diacyglycerol, whereas it shows no positional specificity toward triacylglycerol. Exhibits also esterase activity toward p-nitrophenyl. May act on the brush border membrane to facilitate the absorption of digested lipids (By similarity)..
• Protein Sequence: MGLRPGIFLLELLLLLGQGTPQIHTSPRKSTLEGQLWPETLKNSPFPCNPNKLGVNMPSKSVHSLKPSDIKFVAAIGNLEIPPDPGTGDLEKQDWTERPQQVCMGVMTVLSDIIRYFSPSVPMPVCHTGKRVIPHDGAEDLWIQAQELVRNMKENLQLDFQFDWKLINVFFSNASQCYLCPSAQQNGLAAGGVDELMGVLDYLQQEVPRAFVNLVDLSEVAEVSRQYHGTWLSPAPEPCNCSEETTRLAKVVMQWSYQEAWNSLLASSRYSEQESFTVVFQPFFYETTPSLHSEDPRLQDSTTLAWHLWNRMMEPAGEKDEPLSVKHGRPMKCPSQESPYLFSYRNSNYLTRLQKPQDKLEVREGAEIRCPDKDPSDTVPTSVHRLKPADINVIGALGDSLTAGNGAGSTPGNVLDVLTQYRGLSWSVGGDENIGTVTTLANILREFNPSLKGFSVGTGKETSPNAFLNQAVAGGRAEDLPVQARRLVDLMKNDTRIHFQEDWKIITLFIGGNDLCDFCNDLVHYSPQNFTDNIGKALDILHAEVPRAFVNLVTVLEIVNLRELYQEKKVYCPRMILRSLCPCVLKFDDNSTELATLIEFNKKFQEKTHQLIESGRYDTREDFTVVVQPFFENVDMPKTSEGLPDNSFFAPDCFHFSSKSHSRAASALWNNMLEPVGQKTTRHKFENKINITCPNQVQPFLRTYKNSMQGHGTWLPCRDRAPSALHPTSVHALRPADIQVVAALGDSLTAGNGIGSKPDDLPDVTTQYRGLSYSAGGDGSLENVTTLPNILREFNRNLTGYAVGTGDANDTNAFLNQAVPGAKAEDLMSQVQTLMQKMKDDHRVNFHEDWKVITVLIGGSDLCDYCTDSNLYSAANFVHHLRNALDVLHREVPRVLVNLVDFLNPTIMRQVFLGNPDKCPVQQASVLCNCVLTLRENSQELARLEAFSRAYRSSMRELVGSGRYDTQEDFSVVLQPFFQNIQLPVLADGLPDTSFFAPDCIHPNQKFHSQLARALWTNMLEPLGSKTETLDLRAEMPITCPTQNEPFLRTPRNSNYTYPIKPAIENWGSDFLCTEWKASNSVPTSVHQLRPADIKVVAALGDSLTTAVGARPNNSSDLPTSWRGLSWSIGGDGNLETHTTLPNILKKFNPYLLGFSTSTWEGTAGLNVAAEGARARDMPAQAWDLVERMKNSPDINLEKDWKLVTLFIGVNDLCHYCENPEAHLATEYVQHIQQALDILSEELPRAFVNVVEVMELASLYQGQGGKCAMLAAQNNCTCLRHSQSSLEKQELKKVNWNLQHGISSFSYWHQYTQREDFAVVVQPFFQNTLTPLNERGDTDLTFFSEDCFHFSDRGHAEMAIALWNNMLEPVGRKTTSNNFTHSRAKLKCPSPESPYLYTLRNSRLLPDQAEEAPEVLYWAVPVAAGVGLVVGIIGTVVWRCRRGGRREDPPMSLRTVAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
130	Sumoylation	MPVCHTGKRVIPHDG CCCCCCCCCCCCCCC	44.65	-
130	Sumoylation	MPVCHTGKRVIPHDG CCCCCCCCCCCCCCC	44.65	-
173	N-linked_Glycosylation	LINVFFSNASQCYLC HHHHHCCCCCCEEEC	38.15	-
240	N-linked_Glycosylation	SPAPEPCNCSEETTR CCCCCCCCCCHHHHH	42.96	UniProtKB CARBOHYD
464 (in isoform 2)	Phosphorylation	-	43.52	29083192
470 (in isoform 2)	Phosphorylation	-	39.08	29083192
472 (in isoform 2)	Phosphorylation	-	3.51	29083192
475 (in isoform 2)	Phosphorylation	-	18.85	29083192
493	N-linked_Glycosylation	RLVDLMKNDTRIHFQ HHHHHHHCCCEEEEC	41.75	UniProtKB CARBOHYD
529	N-linked_Glycosylation	LVHYSPQNFTDNIGK HHCCCCCCCCCCHHH	45.21	UniProtKB CARBOHYD
590	N-linked_Glycosylation	CVLKFDDNSTELATL EEEECCCCCHHHHHH	53.31	-
690	N-linked_Glycosylation	HKFENKINITCPNQV CCCCCCCCCCCCCCH	25.73	-
723	Phosphorylation	PCRDRAPSALHPTSV ECCCCCCCCCCCCCC	42.34	22673903
728	Phosphorylation	APSALHPTSVHALRP CCCCCCCCCCCCCCH	32.41	22673903
729	Phosphorylation	PSALHPTSVHALRPA CCCCCCCCCCCCCHH	19.16	22673903
783	N-linked_Glycosylation	GGDGSLENVTTLPNI CCCCCCHHHHCHHHH	41.55	-
797	N-linked_Glycosylation	ILREFNRNLTGYAVG HHHHHHHCCCCEEEC	42.96	UniProtKB CARBOHYD
809	N-linked_Glycosylation	AVGTGDANDTNAFLN EECCCCCCCHHHHHH	62.47	-
961	Phosphorylation	SMRELVGSGRYDTQE HHHHHHCCCCCCCHH	16.77	27251275
1017	Phosphorylation	QLARALWTNMLEPLG HHHHHHHHHHCCCCC	16.17	25954137
1029	Phosphorylation	PLGSKTETLDLRAEM CCCCCCCEEEEEECC	30.70	25954137
1055	N-linked_Glycosylation	LRTPRNSNYTYPIKP CCCCCCCCCCCCCCC	36.39	UniProtKB CARBOHYD
1113	N-linked_Glycosylation	TAVGARPNNSSDLPT HHCCCCCCCCCCCCC	56.30	-
1115	Phosphorylation	VGARPNNSSDLPTSW CCCCCCCCCCCCCCC	31.69	28842319
1116	Phosphorylation	GARPNNSSDLPTSWR CCCCCCCCCCCCCCC	45.34	28842319
1128	Phosphorylation	SWRGLSWSIGGDGNL CCCCCEEECCCCCCC	14.15	-
1139	Phosphorylation	DGNLETHTTLPNILK CCCCCCCCCHHHHHH	37.13	-
1140	Phosphorylation	GNLETHTTLPNILKK CCCCCCCCHHHHHHH	32.39	-
1192	Phosphorylation	LVERMKNSPDINLEK HHHHHHCCCCCCCHH	20.59	29743597
1275	N-linked_Glycosylation	AMLAAQNNCTCLRHS HHHHHHCCCEECCCC	15.47	-
1378	N-linked_Glycosylation	GRKTTSNNFTHSRAK CCCCCCCCCCCCCCC	42.85	-
1398	Phosphorylation	PESPYLYTLRNSRLL CCCCCEEEECCCCCC	19.35	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLB1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLB1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLB1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CGAT2_HUMAN	CSGALNACT2	physical	28514442
PERM_HUMAN	MPO	physical	28514442
WDR47_HUMAN	WDR47	physical	28514442
GILT_HUMAN	IFI30	physical	28514442
TCPB_HUMAN	CCT2	physical	28514442
TCPW_HUMAN	CCT6B	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.