CSRP3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CSRP3_HUMAN
• UniProt AC: P50461
• Protein Name: Cysteine and glycine-rich protein 3
• Gene Name: CSRP3
• Organism: Homo sapiens (Human).
• Sequence Length: 194
• Subcellular Localization: Nucleus . Cytoplasm . Cytoplasm, cytoskeleton . Cytoplasm, myofibril, sarcomere, Z line . Cytoplasm, myofibril, sarcomere . Nucleocytoplasmic shuttling protein. Mainly cytoplasmic. In the Z line, found associated with GLRX3 (By similarity).; Isoform
• Protein Description: Positive regulator of myogenesis. Acts as cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6. Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and may promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis (By similarity). Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation (By similarity). The role in regulation of cytoskeleton dynamics by association with CFL2 is reported conflictingly: Shown to enhance CFL2-mediated F-actin depolymerization dependent on the CSRP3:CFL2 molecular ratio, and also shown to reduce the ability of CLF1 and CFL2 to enhance actin depolymerization. [PubMed: 19752190]
• Protein Sequence: MPNWGGGAKCGACEKTVYHAEEIQCNGRSFHKTCFHCMACRKALDSTTVAAHESEIYCKVCYGRRYGPKGIGYGQGAGCLSTDTGEHLGLQFQQSPKPARSVTTSNPSKFTAKFGESEKCPRCGKSVYAAEKVMGGGKPWHKTCFRCAICGKSLESTNVTDKDGELYCKVCYAKNFGPTGIGFGGLTQQVEKKE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	KCGACEKTVYHAEEI CCCCCCCEEEECCEE	12.19	-
18	Phosphorylation	GACEKTVYHAEEIQC CCCCCEEEECCEEEE	10.67	-
54	Phosphorylation	TTVAAHESEIYCKVC CCEEEECCCEEEEEE	21.30	-
57	Phosphorylation	AAHESEIYCKVCYGR EEECCCEEEEEECCC	5.12	-
69	Acetylation	YGRRYGPKGIGYGQG CCCCCCCCCCCCCCC	59.81	9329223
73	Phosphorylation	YGPKGIGYGQGAGCL CCCCCCCCCCCCCEE	12.35	22673903
81	Phosphorylation	GQGAGCLSTDTGEHL CCCCCEEECCCCCCC	28.45	26437602
82	Phosphorylation	QGAGCLSTDTGEHLG CCCCEEECCCCCCCE	25.32	22673903
84	Phosphorylation	AGCLSTDTGEHLGLQ CCEEECCCCCCCEEE	44.55	22673903
95	Phosphorylation	LGLQFQQSPKPARSV CEEEECCCCCCCCCC	24.90	19764811
101	Phosphorylation	QSPKPARSVTTSNPS CCCCCCCCCCCCCHH	26.39	26437602
103	Phosphorylation	PKPARSVTTSNPSKF CCCCCCCCCCCHHHE	26.25	26437602
108	Phosphorylation	SVTTSNPSKFTAKFG CCCCCCHHHEEEECC	44.65	26437602
126	Phosphorylation	KCPRCGKSVYAAEKV CCCCCCCCCHHHHHH	12.97	26437602
128	Phosphorylation	PRCGKSVYAAEKVMG CCCCCCCHHHHHHHC	13.74	26437602
132	Ubiquitination	KSVYAAEKVMGGGKP CCCHHHHHHHCCCCC	32.56	-
153	Phosphorylation	RCAICGKSLESTNVT EHHHCCCCEECCCCC	23.74	23879269
156	Phosphorylation	ICGKSLESTNVTDKD HCCCCEECCCCCCCC	30.49	26437602
167	Phosphorylation	TDKDGELYCKVCYAK CCCCCCEEEEEEEEE	5.97	28102081
172	Phosphorylation	ELYCKVCYAKNFGPT CEEEEEEEEECCCCC	24.49	23879269

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CSRP3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CSRP3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CSRP3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LDHD_HUMAN	LDHD	physical	12127981
MYOD1_HUMAN	MYOD1	genetic	9234731
MYOD1_HUMAN	MYOD1	physical	9234731
MYF6_HUMAN	MYF6	physical	9234731
MYOG_HUMAN	MYOG	physical	9234731
HDAC4_HUMAN	HDAC4	physical	18250163
KLF5_HUMAN	KLF5	physical	22584587

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 607482: Cardiomyopathy, dilated 1M (CMD1M)
• 612124: Cardiomyopathy, familial hypertrophic 12 (CMH12)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.