CP46A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CP46A_HUMAN
• UniProt AC: Q9Y6A2
• Protein Name: Cholesterol 24-hydroxylase
• Gene Name: CYP46A1
• Organism: Homo sapiens (Human).
• Sequence Length: 500
• Subcellular Localization: Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.
• Protein Description: Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. Has also activity with xenobiotic compounds, such as clotrimazole..
• Protein Sequence: MSPGLLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRPRGWQPAPPPPPC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSPGLLLLG ------CCHHHHHHH	27.89	24043423
10	Phosphorylation	PGLLLLGSAVLLAFG HHHHHHHHHHHHHHH	18.38	24043423
21	Phosphorylation	LAFGLCCTFVHRARS HHHHHHHHHHHHHHH	27.91	24043423
28	Phosphorylation	TFVHRARSRYEHIPG HHHHHHHHHCCCCCC	37.92	24043423
83	Phosphorylation	RVNVFHKTSVIVTSP EEEEEECCEEEEECH	21.47	27762562
83	O-linked_Glycosylation	RVNVFHKTSVIVTSP EEEEEECCEEEEECH	21.47	30620550
88	Phosphorylation	HKTSVIVTSPESVKK ECCEEEEECHHHHHH	27.69	27762562
88	O-linked_Glycosylation	HKTSVIVTSPESVKK ECCEEEEECHHHHHH	27.69	30620550
89	Phosphorylation	KTSVIVTSPESVKKF CCEEEEECHHHHHHH	18.77	27762562
92	Phosphorylation	VIVTSPESVKKFLMS EEEECHHHHHHHHHC	42.49	27762562
100	Phosphorylation	VKKFLMSTKYNKDSK HHHHHHCCCCCCCHH	24.47	28509920
102	Phosphorylation	KFLMSTKYNKDSKMY HHHHCCCCCCCHHHH	27.77	28509920
146	Phosphorylation	RVIDLAFSRSSLVSL HHHHHHCCHHHHHHH	26.16	-
148	Phosphorylation	IDLAFSRSSLVSLME HHHHCCHHHHHHHHH	27.16	-
338	Phosphorylation	EVDEVIGSKRYLDFE HHHHHHCCCCCCCHH	11.66	23403867
339	Ubiquitination	VDEVIGSKRYLDFED HHHHHCCCCCCCHHH	39.59	30230243
341	Phosphorylation	EVIGSKRYLDFEDLG HHHCCCCCCCHHHHH	17.85	-
352	Phosphorylation	EDLGRLQYLSQVLKE HHHHHHHHHHHHHHH	16.95	-
354	Phosphorylation	LGRLQYLSQVLKESL HHHHHHHHHHHHHHH	17.20	-
358	Ubiquitination	QYLSQVLKESLRLYP HHHHHHHHHHHHHCC	46.53	30230243
389	Phosphorylation	GVRVPGNTPLLFSTY CEECCCCCCEEEEEE	22.64	28270605
394	Phosphorylation	GNTPLLFSTYVMGRM CCCCEEEEEECCCCC	20.85	28851738
395	Phosphorylation	NTPLLFSTYVMGRMD CCCEEEEEECCCCCC	16.89	28851738
396	Phosphorylation	TPLLFSTYVMGRMDT CCEEEEEECCCCCCC	6.29	28851738
426	Phosphorylation	GAPKPRFTYFPFSLG CCCCCCEEECCCCCC	26.07	29978859
427	Phosphorylation	APKPRFTYFPFSLGH CCCCCEEECCCCCCC	13.42	29978859
431	Phosphorylation	RFTYFPFSLGHRSCI CEEECCCCCCCCHHH	33.41	29978859
436	Phosphorylation	PFSLGHRSCIGQQFA CCCCCCCHHHCHHHH	12.38	29978859

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CP46A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CP46A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CP46A_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CP46A_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.