ASB8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ASB8_HUMAN
• UniProt AC: Q9H765
• Protein Name: Ankyrin repeat and SOCS box protein 8
• Gene Name: ASB8
• Organism: Homo sapiens (Human).
• Sequence Length: 288
• Subcellular Localization: Cytoplasm .
• Protein Description: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins..
• Protein Sequence: MSSSMWYIMQSIQSKYSLSERLIRTIAAIRSFPHDNVEDLIRGGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPISRLVALLVRGLGTEKEDSCFELLHRAVGHFELRKNGTMPREVARDPQLCEKLTVLCSAPGTLKTLARYAVRRSLGLQYLPDAVKGLPLPASLKEYLLLLE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSSMWYIM ------CCHHHHHHH	30.99	23663014
3	Phosphorylation	-----MSSSMWYIMQ -----CCHHHHHHHH	23.94	23663014
4	Phosphorylation	----MSSSMWYIMQS ----CCHHHHHHHHH	13.16	23663014
7	Phosphorylation	-MSSSMWYIMQSIQS -CCHHHHHHHHHHHH	4.29	23663014
11	Phosphorylation	SMWYIMQSIQSKYSL HHHHHHHHHHHCCCH	12.76	23663014
14	Phosphorylation	YIMQSIQSKYSLSER HHHHHHHHCCCHHHH	31.71	23663014
17	Phosphorylation	QSIQSKYSLSERLIR HHHHHCCCHHHHHHH	29.20	-
31	Phosphorylation	RTIAAIRSFPHDNVE HHHHHHHCCCCCCHH	36.70	-
85	Phosphorylation	EVNALDGYNRTALHY CCCCCCCCCHHHHHH	10.92	-
203	Ubiquitination	VRGLGTEKEDSCFEL HHCCCCCCCHHHHHH	67.66	-
239	Ubiquitination	RDPQLCEKLTVLCSA CCHHHHHHHHHHHCC	48.76	-
241	Phosphorylation	PQLCEKLTVLCSAPG HHHHHHHHHHHCCCC	23.62	21712546
249	Phosphorylation	VLCSAPGTLKTLARY HHHCCCCHHHHHHHH	24.83	21712546
251	Ubiquitination	CSAPGTLKTLARYAV HCCCCHHHHHHHHHH	41.13	-
272	Ubiquitination	QYLPDAVKGLPLPAS CCCCHHHCCCCCCCH	57.35	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
17	S	Phosphorylation	Kinase	IKKE	Q14164	PSP
17	S	Phosphorylation	Kinase	TBK1	Q9UHD2	PSP
31	S	Phosphorylation	Kinase	IKKB	O14920	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ASB8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ASB8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ELOB_HUMAN	TCEB2	physical	12559969
ELOC_HUMAN	TCEB1	physical	12559969
MCM7_HUMAN	MCM7	physical	21988832
RCN1_HUMAN	RCN1	physical	21988832
ELOC_HUMAN	TCEB1	physical	21988832
SRTD1_HUMAN	SERTAD1	physical	21988832
ZC3H6_HUMAN	ZC3H6	physical	24337577
CUL5_HUMAN	CUL5	physical	24337577
HIF1N_HUMAN	HIF1AN	physical	24337577
NEDD8_HUMAN	NEDD8	physical	24337577
ELOC_HUMAN	TCEB1	physical	24337577
ELOB_HUMAN	TCEB2	physical	24337577
PCNA_HUMAN	PCNA	physical	24337577
TMEDA_HUMAN	TMED10	physical	24337577
TBB3_HUMAN	TUBB3	physical	24337577
AMRA1_HUMAN	AMBRA1	physical	24337577
KI26B_HUMAN	KIF26B	physical	24337577
CMC2_HUMAN	SLC25A13	physical	24337577
ADT3_HUMAN	SLC25A6	physical	24337577
CUL5_HUMAN	CUL5	physical	26186194
HIF1N_HUMAN	HIF1AN	physical	26186194
NPAT_HUMAN	NPAT	physical	26186194
TRI11_HUMAN	TRIM11	physical	26186194
AMRA1_HUMAN	AMBRA1	physical	26186194
CUL5_HUMAN	CUL5	physical	28514442
SYIM_HUMAN	IARS2	physical	28514442
HIF1N_HUMAN	HIF1AN	physical	28514442
NPAT_HUMAN	NPAT	physical	28514442
TRI11_HUMAN	TRIM11	physical	28514442
AMRA1_HUMAN	AMBRA1	physical	28514442
RUFY3_HUMAN	RUFY3	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.