ZC3H6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZC3H6_HUMAN
• UniProt AC: P61129
• Protein Name: Zinc finger CCCH domain-containing protein 6
• Gene Name: ZC3H6
• Organism: Homo sapiens (Human).
• Sequence Length: 1189
• Protein Sequence: MTDSEHAGHDREDGELEDGEIDDAGFEEIQEKEAKENEKQKSEKAYRKSRKKHKKEREKKKSKRRKREKHKHNSPSSDDSSDYSLDSDVEHTESSHKKRTGFYRDYDIPFTQRGHISGSYITSKKGQHNKKFKSKEYDEYSTYSDDNFGNYSDDNFGNYGQETEEDFANQLKQYRQAKETSNIALGSSFSKESGKKQRMKGVQQGIEQRVKSFNVGRGRGLPKKIKRKERGGRTNKGPNVFSVSDDFQEYNKPGKKWKVMTQEFINQHTVEHKGKQICKYFLEGRCIKGDQCKFDHDAELEKRKEICKFYLQGYCTKGENCIYMHNEFPCKFYHSGAKCYQGDNCKFSHDDLTKETKKLLDKVLNTDEELINEDERELEELRKRGITPLPKPPPGVGLLPTPPEHFPFSDPEDDFQTDFSDDFRKIPSLFEIVVKPTVDLAHKIGRKPPAFYTSASPPGPQFQGSSPHPQHIYSSGSSPGPGPNMSQGHSSPVMHPGSPGHHPCAGPPGLPVPQSPPLPPGPPEIVGPQNQAGVLVQPDTSLTPPSMGGAYHSPGFPGHVMKVPRENHCSPGSSYQQSPGEMQLNTNYESLQNPAEFYDNYYAQHSIHNFQPPNNSGDGMWHGEFAQQQPPVVQDSPNHGSGSDGSSTRTGHGPLPVPGLLPAVQRALFVRLTQRYQEDEEQTSTQPHRAPSKEEDDTVNWYSSSEEEEGSSVKSILKTLQKQTETLRNQQQPSTELSTPTDPRLAKEKSKGNQVVDPRLRTIPRQDIRKPSESAPLDLRLAWDPRKLRGNGSGHIGSSVGGAKFDLHHANAGTNVKHKRGDDDDEDTERELREKAFLIPLDASPGIMLQDPRSQLRQFSHIKMDITLTKPNFAKHIVWAPEDLLPVPLPKPDPVSSINLPLPPLIADQRLNRLWNTKSDLHQNTVSIDPKLAAKAKINTTNREGYLEQFGDSHGSGAKLGDPRLQKNFDPRLHRLPNTESHQVVMKDSHASKGAPHLPRSNPGSSQPSGAGTSNSGSGALPPYAPKLSSSAGLPLGTSTSVLSGISLYDPRDHGSSSTSELATASSGENSKNQKKSGGLKSSDKTEPSPGEAILPQKPSPNVGVTLEGPADPQADVPRSSGKVQVPAVHSLPVQALTGLIRPQYSDPRQARQPGQGSPTPDNDPGRETDDKSLKEVFKTFDPTASPFC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTDSEHAGH ------CCCCCCCCC	60.58	25849741
4	Phosphorylation	----MTDSEHAGHDR ----CCCCCCCCCCC	38.42	25849741
106	Phosphorylation	RTGFYRDYDIPFTQR CCCEECCCCCCCCCC	13.53	-
117	Phosphorylation	FTQRGHISGSYITSK CCCCCEECCCEECCC	18.93	28555341
120	Phosphorylation	RGHISGSYITSKKGQ CCEECCCEECCCCCC	16.25	27642862
122	Phosphorylation	HISGSYITSKKGQHN EECCCEECCCCCCCC	26.68	-
123	Phosphorylation	ISGSYITSKKGQHNK ECCCEECCCCCCCCC	23.86	-
187	Phosphorylation	TSNIALGSSFSKESG HCCCCCCCCCCHHHC	29.12	25159151
188	Phosphorylation	SNIALGSSFSKESGK CCCCCCCCCCHHHCC	31.57	21815630
190	Phosphorylation	IALGSSFSKESGKKQ CCCCCCCCHHHCCCH	37.14	23312004
366	Phosphorylation	LLDKVLNTDEELINE HHHHHCCCCHHHCCC	40.40	28348404
401	Phosphorylation	PGVGLLPTPPEHFPF CCCCCCCCCCCCCCC	51.98	29496963
409	Phosphorylation	PPEHFPFSDPEDDFQ CCCCCCCCCCCCCCC	53.12	26657352
417	Phosphorylation	DPEDDFQTDFSDDFR CCCCCCCCCCCHHHH	38.72	28348404
420	Phosphorylation	DDFQTDFSDDFRKIP CCCCCCCCHHHHHCC	38.80	28122231
428	Phosphorylation	DDFRKIPSLFEIVVK HHHHHCCHHHEEEEC	49.52	-
636	Phosphorylation	QPPVVQDSPNHGSGS CCCEEECCCCCCCCC	15.54	24275569
703	Phosphorylation	DDTVNWYSSSEEEEG CCCCCCCCCCHHHCC	21.00	25849741
704	Phosphorylation	DTVNWYSSSEEEEGS CCCCCCCCCHHHCCH	26.52	25849741
705	Phosphorylation	TVNWYSSSEEEEGSS CCCCCCCCHHHCCHH	42.99	23909892
715	Phosphorylation	EEGSSVKSILKTLQK HCCHHHHHHHHHHHH	30.88	24719451
719	Phosphorylation	SVKSILKTLQKQTET HHHHHHHHHHHHHHH	30.86	26270265
724	Phosphorylation	LKTLQKQTETLRNQQ HHHHHHHHHHHHHCC	37.66	26270265
726	Phosphorylation	TLQKQTETLRNQQQP HHHHHHHHHHHCCCC	34.11	26270265
734	Phosphorylation	LRNQQQPSTELSTPT HHHCCCCCCCCCCCC	30.12	27732954
735	Phosphorylation	RNQQQPSTELSTPTD HHCCCCCCCCCCCCC	47.86	27732954
738	Phosphorylation	QQPSTELSTPTDPRL CCCCCCCCCCCCHHH	26.55	25159151
739	Phosphorylation	QPSTELSTPTDPRLA CCCCCCCCCCCHHHH	42.72	25159151
741	Phosphorylation	STELSTPTDPRLAKE CCCCCCCCCHHHHHH	59.74	27732954
772	Phosphorylation	RQDIRKPSESAPLDL HHHCCCCCCCCCCCE	47.41	28555341
844	Phosphorylation	FLIPLDASPGIMLQD EEEECCCCCCCCCCC	24.27	22199227
854	Phosphorylation	IMLQDPRSQLRQFSH CCCCCHHHHHHHHCC	38.67	28674151
919	Phosphorylation	NRLWNTKSDLHQNTV HHHHCCCCCHHCCCC	43.28	-
953	Phosphorylation	YLEQFGDSHGSGAKL HHHHHCCCCCCCCCC	30.08	-
959	Acetylation	DSHGSGAKLGDPRLQ CCCCCCCCCCCHHHH	57.43	25953088
992	O-linked_Glycosylation	VMKDSHASKGAPHLP EECCCCCCCCCCCCC	26.63	OGP
1001	Phosphorylation	GAPHLPRSNPGSSQP CCCCCCCCCCCCCCC	45.49	29978859
1005	Phosphorylation	LPRSNPGSSQPSGAG CCCCCCCCCCCCCCC	27.36	29978859
1006	Phosphorylation	PRSNPGSSQPSGAGT CCCCCCCCCCCCCCC	52.61	29978859
1009	Phosphorylation	NPGSSQPSGAGTSNS CCCCCCCCCCCCCCC	33.37	29978859
1013	Phosphorylation	SQPSGAGTSNSGSGA CCCCCCCCCCCCCCC	24.97	29978859
1014	Phosphorylation	QPSGAGTSNSGSGAL CCCCCCCCCCCCCCC	28.25	29978859
1016	Phosphorylation	SGAGTSNSGSGALPP CCCCCCCCCCCCCCC	33.82	29978859
1018	Phosphorylation	AGTSNSGSGALPPYA CCCCCCCCCCCCCCC	22.25	29978859
1024	Phosphorylation	GSGALPPYAPKLSSS CCCCCCCCCCCCCCC	33.33	29978859
1158	Phosphorylation	ARQPGQGSPTPDNDP CCCCCCCCCCCCCCC	20.08	29255136
1160	Phosphorylation	QPGQGSPTPDNDPGR CCCCCCCCCCCCCCC	45.00	29255136
1169	Phosphorylation	DNDPGRETDDKSLKE CCCCCCCCCCHHHHH	48.41	23403867
1186	Phosphorylation	KTFDPTASPFC---- HHCCCCCCCCC----	22.46	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZC3H6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZC3H6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZC3H6_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ZC3H6_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.