GDE1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GDE1_HUMAN
• UniProt AC: Q9NZC3
• Protein Name: Glycerophosphodiester phosphodiesterase 1
• Gene Name: GDE1
• Organism: Homo sapiens (Human).
• Sequence Length: 331
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Perinuclear vesicles and cell membrane.
• Protein Description: Has glycerophosphoinositol phosphodiesterase activity. Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways (By similarity)..
• Protein Sequence: MWLWEDQGGLLGPFSFLLLVLLLVTRSPVNACLLTGSLFVLLRVFSFEPVPSCRALQVLKPRDRISAIAHRGGSHDAPENTLAAIRQAAKNGATGVELDIEFTSDGIPVLMHDNTVDRTTDGTGRLCDLTFEQIRKLNPAANHRLRNDFPDEKIPTLREAVAECLNHNLTIFFDVKGHAHKATEALKKMYMEFPQLYNNSVVCSFLPEVIYKMRQTDRDVITALTHRPWSLSHTGDGKPRYDTFWKHFIFVMMDILLDWSMHNILWYLCGISAFLMQKDFVSPAYLKKWSAKGIQVVGWTVNTFDEKSYYESHLGSSYITDSMVEDCEPHF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
60	Ubiquitination	CRALQVLKPRDRISA CCEEEECCCHHHHHH	38.87	-
64	Methylation	QVLKPRDRISAIAHR EECCCHHHHHHHHCC	26.49	-
71	Methylation	RISAIAHRGGSHDAP HHHHHHCCCCCCCCC	41.99	-
86	Methylation	ENTLAAIRQAAKNGA HHHHHHHHHHHHCCC	18.50	-
120	Phosphorylation	DNTVDRTTDGTGRLC CCCCCCCCCCCCCCC	33.07	22468782
123	Phosphorylation	VDRTTDGTGRLCDLT CCCCCCCCCCCCCCC	23.18	22468782
130	Phosphorylation	TGRLCDLTFEQIRKL CCCCCCCCHHHHHHH	16.33	22468782
136	Ubiquitination	LTFEQIRKLNPAANH CCHHHHHHHCHHHCC	55.00	-
156	Phosphorylation	FPDEKIPTLREAVAE CCCCCCCHHHHHHHH	41.75	24945436
168	N-linked_Glycosylation	VAECLNHNLTIFFDV HHHHHCCCCEEEEEC	37.49	UniProtKB CARBOHYD
198	N-linked_Glycosylation	MEFPQLYNNSVVCSF HHCHHHHCCCHHHHC	42.78	UniProtKB CARBOHYD
222	Phosphorylation	QTDRDVITALTHRPW CCCHHHHHHHHCCCC	18.57	28348404
225	Phosphorylation	RDVITALTHRPWSLS HHHHHHHHCCCCCCC	17.24	28348404
230	Phosphorylation	ALTHRPWSLSHTGDG HHHCCCCCCCCCCCC	23.76	28348404
232	Phosphorylation	THRPWSLSHTGDGKP HCCCCCCCCCCCCCC	17.31	28348404
234	Phosphorylation	RPWSLSHTGDGKPRY CCCCCCCCCCCCCCC	33.32	28348404
287	2-Hydroxyisobutyrylation	FVSPAYLKKWSAKGI CCCHHHHHHHCCCCE	39.25	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GDE1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GDE1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GDE1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATD3C_HUMAN	ATAD3C	physical	26186194
S4A7_HUMAN	SLC4A7	physical	26186194
REEP5_HUMAN	REEP5	physical	26186194
FA84B_HUMAN	FAM84B	physical	26186194
G3PT_HUMAN	GAPDHS	physical	26186194
PLS1_HUMAN	PLSCR1	physical	26186194
ATLA3_HUMAN	ATL3	physical	26186194
TM109_HUMAN	TMEM109	physical	26186194
EPCR_HUMAN	PROCR	physical	26186194
BRI3B_HUMAN	BRI3BP	physical	26186194
S4A7_HUMAN	SLC4A7	physical	28514442
FA84B_HUMAN	FAM84B	physical	28514442
ATLA3_HUMAN	ATL3	physical	28514442
CDK14_HUMAN	CDK14	physical	28514442
DAZP2_HUMAN	DAZAP2	physical	28514442
G3PT_HUMAN	GAPDHS	physical	28514442
NEUM_HUMAN	GAP43	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.