GNAL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GNAL_HUMAN
• UniProt AC: P38405
• Protein Name: Guanine nucleotide-binding protein G(olf) subunit alpha
• Gene Name: GNAL
• Organism: Homo sapiens (Human).
• Sequence Length: 381
• Protein Description: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters..
• Protein Sequence: MGCLGGNSKTTEDQGVDEKERREANKKIEKQLQKERLAYKATHRLLLLGAGESGKSTIVKQMRILHVNGFNPEEKKQKILDIRKNVKDAIVTIVSAMSTIIPPVPLANPENQFRSDYIKSIAPITDFEYSQEFFDHVKKLWDDEGVKACFERSNEYQLIDCAQYFLERIDSVSLVDYTPTDQDLLRCRVLTSGIFETRFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIYVAACSSYNMVIREDNNTNRLRESLDLFESIWNNRWLRTISIILFLNKQDMLAEKVLAGKSKIEDYFPEYANYTVPEDATPDAGEDPKVTRAKFFIRDLFLRISTATGDGKHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLKQYELL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	N-palmitoylation	------MGCLGGNSK ------CCCCCCCCC	18.50	-
3	S-palmitoylation	-----MGCLGGNSKT -----CCCCCCCCCC	2.85	-
30	Ubiquitination	EANKKIEKQLQKERL HHHHHHHHHHHHHHH	60.83	-
39	Phosphorylation	LQKERLAYKATHRLL HHHHHHHHHHHHHHH	13.02	18083107
48 (in isoform 2)	Phosphorylation	-	4.45	-
53	Phosphorylation	LLLGAGESGKSTIVK HHHCCCCCCCCHHHH	51.07	20873877
55	Ubiquitination	LGAGESGKSTIVKQM HCCCCCCCCHHHHEE	54.42	21890473
56	Phosphorylation	GAGESGKSTIVKQMR CCCCCCCCHHHHEEE	27.22	29514088
57	Phosphorylation	AGESGKSTIVKQMRI CCCCCCCHHHHEEEE	33.02	29514088
60	Acetylation	SGKSTIVKQMRILHV CCCCHHHHEEEEEEE	34.23	25953088
60	Ubiquitination	SGKSTIVKQMRILHV CCCCHHHHEEEEEEE	34.23	21890473
119 (in isoform 2)	Phosphorylation	-	29.58	22210691
132	Ubiquitination	TDFEYSQEFFDHVKK CCCCHHHHHHHHHHH	42.20	21890473
133 (in isoform 2)	Phosphorylation	-	7.27	22210691
137	Ubiquitination	SQEFFDHVKKLWDDE HHHHHHHHHHHHCCH	6.69	21890473
138	Ubiquitination	QEFFDHVKKLWDDEG HHHHHHHHHHHCCHH	38.43	-
139	Ubiquitination	EFFDHVKKLWDDEGV HHHHHHHHHHCCHHH	54.44	-
177	Phosphorylation	DSVSLVDYTPTDQDL CCCEECCCCCCCHHH	13.72	22468782
178	Phosphorylation	SVSLVDYTPTDQDLL CCEECCCCCCCHHHH	18.43	22468782
180	Phosphorylation	SLVDYTPTDQDLLRC EECCCCCCCHHHHHH	38.19	22468782
188	ADP-ribosylation	DQDLLRCRVLTSGIF CHHHHHHEECCCCCC	21.75	-
188	ADP-ribosylation	DQDLLRCRVLTSGIF CHHHHHHEECCCCCC	21.75	-
203	Ubiquitination	ETRFQVDKVNFHMFD EEEEEECEEEEEEEE	39.97	21890473
256	Phosphorylation	NTNRLRESLDLFESI CHHHHHHHHHHHHHH	22.28	-
292	Ubiquitination	AEKVLAGKSKIEDYF HHHHHCCCHHHHHHC	42.86	21890473
294	Ubiquitination	KVLAGKSKIEDYFPE HHHCCCHHHHHHCHH	54.31	-
302	Phosphorylation	IEDYFPEYANYTVPE HHHHCHHHCCCCCCC	10.61	26657352
306	Phosphorylation	FPEYANYTVPEDATP CHHHCCCCCCCCCCC	29.41	26657352
320	Ubiquitination	PDAGEDPKVTRAKFF CCCCCCCCHHHHHHH	69.43	-
345	Phosphorylation	ATGDGKHYCYPHFTC CCCCCCCCEECCCEE	9.36	28152594
347	Phosphorylation	GDGKHYCYPHFTCAV CCCCCCEECCCEEEE	7.80	28152594

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GNAL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GNAL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GNAL_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of GNAL_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615073: Dystonia 25 (DYT25)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.