EMAL2_HUMAN - dbPTM
EMAL2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID EMAL2_HUMAN
UniProt AC O95834
Protein Name Echinoderm microtubule-associated protein-like 2
Gene Name EML2
Organism Homo sapiens (Human).
Sequence Length 649
Subcellular Localization Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, spindle . Colocalizes with the microtubule cytoskeleton. Colocalizes with the mitotic spindle.
Protein Description Tubulin binding protein that inhibits microtubule nucleation and growth, resulting in shorter microtubules..
Protein Sequence MSSFGAGKTKEVIFSVEDGSVKMFLRGRPVPMMIPDELAPTYSLDTRSELPSCRLKLEWVYGYRGRDCRANLYLLPTGEIVYFVASVAVLYSVEEQRQRHYLGHNDDIKCLAIHPDMVTIATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSKSNGGNLLCAVDESNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIYFWTLEGGSLSKRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQAVLGAHDGGVFGLCALRDGTLVSGGGRDRRVVLWGSDYSKLQEVEVPEDFGPVRTVAEGHGDTLYVGTTRNSILQGSVHTGFSLLVQGHVEELWGLATHPSRAQFVTCGQDKLVHLWSSDSHQPLWSRIIEDPARSAGFHPSGSVLAVGTVTGRWLLLDTETHDLVAIHTDGNEQISVVSFSPDGAYLAVGSHDNLVYVYTVDQGGRKVSRLGKCSGHSSFITHLDWAQDSSCFVTNSGDYEILYWDPATCKQITSADAVRNMEWATATCVLGFGVFGIWSEGADGTDINAVARSHDGKLLASADDFGKVHLFSYPCCQPRALSHKYGGHSSHVTNVAFLWDDSMALTTGGKDTSVLQWRVV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSSFGAGKT
------CCCCCCCCC		34.0824719451
8AcetylationMSSFGAGKTKEVIFS
CCCCCCCCCEEEEEE		56.7625953088
8 (in isoform 2)Phosphorylation-56.7623663014
10UbiquitinationSFGAGKTKEVIFSVE
CCCCCCCEEEEEEEC		54.1721906983
10 (in isoform 2)Phosphorylation-54.1723663014
11 (in isoform 2)Phosphorylation-46.1823663014
12UbiquitinationGAGKTKEVIFSVEDG
CCCCCEEEEEEECCC		5.9627667366
15PhosphorylationKTKEVIFSVEDGSVK
CCEEEEEEECCCCEE		17.3024505115
22AcetylationSVEDGSVKMFLRGRP
EECCCCEEEEECCEE		26.157677589
32SulfoxidationLRGRPVPMMIPDELA
ECCEECCEECCCHHC		3.7630846556
33SulfoxidationRGRPVPMMIPDELAP
CCEECCEECCCHHCC		3.0930846556
55 (in isoform 3)Phosphorylation-9.7227732954
56UbiquitinationELPSCRLKLEWVYGY
CCCCCEEEEEEHHCC		25.63-
62 (in isoform 3)Phosphorylation-8.9527732954
64 (in isoform 3)Phosphorylation-29.3427732954
65 (in isoform 3)Phosphorylation-22.6927732954
76 (in isoform 2)Phosphorylation-35.4428348404
81UbiquitinationLLPTGEIVYFVASVA
EECCCCEEEEEEEHH		2.3627667366
86 (in isoform 2)Phosphorylation-12.8125627689
102 (in isoform 2)Phosphorylation-4.6127732954
104 (in isoform 2)Phosphorylation-31.7623663014
105 (in isoform 2)Phosphorylation-47.0225159151
107 (in isoform 2)Phosphorylation-47.7925159151
108 (in isoform 2)Phosphorylation-3.6525159151
109AcetylationLGHNDDIKCLAIHPD
CCCCCCCEEEEECCC		30.1425953088
114 (in isoform 2)Phosphorylation-13.5027174698
115 (in isoform 2)Phosphorylation-25.8627174698
123 (in isoform 2)Phosphorylation-15.7927174698
125 (in isoform 2)Phosphorylation-5.8522617229
130 (in isoform 3)Phosphorylation-65.3928348404
131 (in isoform 2)Phosphorylation-71.0624719451
140 (in isoform 3)Phosphorylation-22.6525627689
142UbiquitinationLPPHVRIWDSVSLST
CCCCCEEEECCCHHH		4.9323503661
143 (in isoform 2)Phosphorylation-36.47-
156 (in isoform 3)Phosphorylation-19.0827732954
157UbiquitinationLHVLGLGVFDRAVCC
HHHCCCCCCCCEEEE		5.6129967540
157 (in isoform 2)Ubiquitination-5.61-
158 (in isoform 3)Phosphorylation-5.0923663014
159PhosphorylationVLGLGVFDRAVCCVG
HCCCCCCCCEEEEEE		34.9124719451
159 (in isoform 3)Phosphorylation-34.9125159151
161PhosphorylationGLGVFDRAVCCVGFS
CCCCCCCEEEEEEEE		10.67-
161 (in isoform 3)Phosphorylation-10.6725159151
162PhosphorylationLGVFDRAVCCVGFSK
CCCCCCEEEEEEEEC		2.4324719451
162 (in isoform 3)Phosphorylation-2.4325159151
168 (in isoform 3)Phosphorylation-29.2827174698
169 (in isoform 3)Phosphorylation-45.7527174698
175UbiquitinationSKSNGGNLLCAVDES
ECCCCCCEEEEEECC		4.7427667366
176UbiquitinationKSNGGNLLCAVDESN
CCCCCCEEEEEECCC		1.7221906983
177PhosphorylationSNGGNLLCAVDESND
CCCCCEEEEEECCCC		3.8024719451
177 (in isoform 3)Phosphorylation-3.8027174698
179PhosphorylationGGNLLCAVDESNDHM
CCCEEEEEECCCCCE		9.0624719451
179 (in isoform 3)Phosphorylation-9.0622617229
185PhosphorylationAVDESNDHMLSVWDW
EEECCCCCEEEHHHH		24.2724719451
185 (in isoform 3)Phosphorylation-24.2724719451
194UbiquitinationLSVWDWAKETKVVDV
EEHHHHHCCCCEEEE		62.7629967540
197PhosphorylationWDWAKETKVVDVKCS
HHHHCCCCEEEEEEC		41.16-
197UbiquitinationWDWAKETKVVDVKCS
HHHHCCCCEEEEEEC		41.1627667366
197 (in isoform 3)Phosphorylation-41.16-
211UbiquitinationSNEAVLVATFHPTDP
CCCEEEEEEECCCCC		10.6123503661
227PhosphorylationVLITCGKSHIYFWTL
EEEEECCCEEEEEEE		10.6228258704
230PhosphorylationTCGKSHIYFWTLEGG
EECCCEEEEEEECCC		6.4028258704
248UbiquitinationKRQGLFEKHEKPKYV
CCCCCCCCCCCCCEE		50.1329967540
295UbiquitinationAVLGAHDGGVFGLCA
HHHCCCCCCEEEEEE		25.0523503661
305UbiquitinationFGLCALRDGTLVSGG
EEEEEEECCEEEECC		56.1123503661
327UbiquitinationLWGSDYSKLQEVEVP
EECCCCHHCEEEECC		48.2121906983
341UbiquitinationPEDFGPVRTVAEGHG
CCCCCCCEEEEECCC		26.9829967540
343UbiquitinationDFGPVRTVAEGHGDT
CCCCCEEEEECCCCE		2.9827667366
344UbiquitinationFGPVRTVAEGHGDTL
CCCCEEEEECCCCEE		19.2127667366
359PhosphorylationYVGTTRNSILQGSVH
EEECCCCCEEECCCC		22.7624043423
364PhosphorylationRNSILQGSVHTGFSL
CCCEEECCCCCCHHH		9.5824043423
367PhosphorylationILQGSVHTGFSLLVQ
EEECCCCCCHHHEEE		37.4524043423
370PhosphorylationGSVHTGFSLLVQGHV
CCCCCCHHHEEECCH		23.3424043423
385PhosphorylationEELWGLATHPSRAQF
HHHHHCCCCCCCCEE		39.0924043423
388PhosphorylationWGLATHPSRAQFVTC
HHCCCCCCCCEEEEE		32.4224043423
395UbiquitinationSRAQFVTCGQDKLVH
CCCEEEEECCCEEEE		3.7629967540
397UbiquitinationAQFVTCGQDKLVHLW
CEEEEECCCEEEEEE		46.9727667366
398UbiquitinationQFVTCGQDKLVHLWS
EEEEECCCEEEEEEE		31.3827667366
399UbiquitinationFVTCGQDKLVHLWSS
EEEECCCEEEEEEEC		44.51-
401UbiquitinationTCGQDKLVHLWSSDS
EECCCEEEEEEECCC		4.2523503661
449UbiquitinationWLLLDTETHDLVAIH
EEEEECCCCEEEEEE		23.8429967540
470UbiquitinationISVVSFSPDGAYLAV
EEEEEECCCCCEEEE		41.8823503661
473UbiquitinationVSFSPDGAYLAVGSH
EEECCCCCEEEEECC		11.9823503661
474UbiquitinationSFSPDGAYLAVGSHD
EECCCCCEEEEECCC		10.7523503661
483UbiquitinationAVGSHDNLVYVYTVD
EEECCCCEEEEEEEC		3.5123503661
493UbiquitinationVYTVDQGGRKVSRLG
EEEECCCCCEEEECE		22.1721906983
496UbiquitinationVDQGGRKVSRLGKCS
ECCCCCEEEECEECC		3.7623503661
527UbiquitinationCFVTNSGDYEILYWD
CEEECCCCEEEEEEC		37.4023503661
528UbiquitinationFVTNSGDYEILYWDP
EEECCCCEEEEEECH		14.3723503661
553PhosphorylationAVRNMEWATATCVLG
HHHCCHHHHHHHEEE		3.6627642862
554UbiquitinationVRNMEWATATCVLGF
HHCCHHHHHHHEEEC		24.4623503661
564UbiquitinationCVLGFGVFGIWSEGA
HEEECEEEEEECCCC		6.3423503661
586UbiquitinationVARSHDGKLLASADD
EEECCCCCEEEECCC		46.512190698
596AcetylationASADDFGKVHLFSYP
EECCCCCCEEEEECC		26.8626051181
596UbiquitinationASADDFGKVHLFSYP
EECCCCCCEEEEECC		26.86-
611PhosphorylationCCQPRALSHKYGGHS
CCCCCHHCCCCCCCC		19.5626434552
631PhosphorylationVAFLWDDSMALTTGG
EEEEECCCEEEECCC		11.9526434552
635PhosphorylationWDDSMALTTGGKDTS
ECCCEEEECCCCCCC		17.5426434552
636PhosphorylationDDSMALTTGGKDTSV
CCCEEEECCCCCCCE		44.8026434552
732Ubiquitination------------------------------------------------------------------------------------------
------------------------------------------------------------------------------------------		23503661
733Ubiquitination-------------------------------------------------------------------------------------------
-------------------------------------------------------------------------------------------		23503661
742Ubiquitination----------------------------------------------------------------------------------------------------
----------------------------------------------------------------------------------------------------		23503661
752Ubiquitination--------------------------------------------------------------------------------------------------------------
--------------------------------------------------------------------------------------------------------------		21906983
755Ubiquitination-----------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------		23503661
786Ubiquitination------------------------------------------------------------------------------------------------------------------------------------------------
------------------------------------------------------------------------------------------------------------------------------------------------		23503661
787Ubiquitination-------------------------------------------------------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------------------------------------------------------------------------------		23503661
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of EMAL2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of EMAL2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of EMAL2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
EXD1_HUMANEXD1physical
25416956
TTC38_HUMANTTC38physical
26344197
EMAL3_HUMANEML3physical
25740311
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of EMAL2_HUMAN

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Related Literatures of Post-Translational Modification

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